Clinical features


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Lung samples from 12 COVID-19 victims were assessed. The main site of viral replication was the pulmonary alveoli wherein most of the coagulatory events also occurred. Accumulation of CD163+ macrophages and the disappearance of T cells, B cells and NK cells were some of the inflammatory responses.
PMID
Title Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death
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Findings from 3-dimensional histological imaging of lung sample from a COVID-19 victim were reported. Pulmonary microangiopathy that involved activated megakaryocyte in the lungs were found to be the major cause of death.
PMID
Title Multiscale 3-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
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Sublingual microcirculation was assessed in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome(ARDS). Sublingual microcirculation was characterized by decreases in the proportion of perfused vessel and flow velocity, along with high vascular densities,which may indicate enhanced angiogenesis or hypoxia-induced capillary recruitment.
PMID 33096349
Title Microcirculation alterations in severe COVID-19 pneumonia
Author(s) nameKanoore Edul VS, Caminos Eguillor JF, Ferrara G, Estenssoro E, Siles DSP, Cesio CE, Dubin A.
Journal J Crit Care
Impact factor2.83
Citation count2
Date of publishing2021 Feb
Five patients who were tested positive for COVID-19 showing clinical features for pulmonary thromboembolism (PTE), resulting in the death of two of the patients. The average time for the onset of PTE was 2-4 weeks.
PMID 33075608
Title The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series
Author(s) nameSakr Y, Giovini M, Leone M, Pizzilli G, Kortgen A, Bauer M, Tonetti T, Duclos G, Zieleskiewicz L, Buschbeck S, Ranieri VM, Antonucci E.
Journal J Crit Care
Impact factor2.83
Citation count1
Date of publishing2021 Feb
In critically ill COVID-19 patients, a decrease in Diaphramatic thickening fraction (DTF) can be used to predict the failure of continuous positive airway pressure (CPAP) and requirement of invasive ventilation.
PMID 33197604
Title Diaphragmatic thickening fraction as a potential predictor of response to continuous positive airway pressure ventilation in Covid-19 pneumonia: A single-center pilot study
Author(s) nameCorradi F, Vetrugno L, Orso D, Bove T, Schreiber A, Boero E, Santori G, Isirdi A, Barbieri G, Forfori F.
Journal Respir Physiol Neurobiol
Impact factor1.55
Citation count1
Date of publishing2021 Feb
A 47-year-old COVID-19 patient devloped pneumonia along with Guillain-Barr Syndrome (GBS). Blood test revealed increased levels of IL-6 and aldosterone indicating primary aldosteronism.
PMID 32749708
Title Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia?
Author(s) nameCampana P, Flocco V, Aruta F, Cacciatore F, Abete P.
Journal J Med Virol
Impact factor2.07
Citation count1
Date of publishing2021 Feb
A combination of mechanical ventilation(MV) and Extracorporeal membrane oxygenation (ECMO) was used to treat a pregnant female with COVID-19 with Acute respiratory distress syndrome (ARDS) successfully.
PMID 32948334
Title First successful treatment of a COVID-19 pregnant woman with severe ARDS by combining early mechanical ventilation and ECMO
Author(s) nameHou L, Li M, Guo K, Wang W, Li B, Li J, Yuan Y.
Journal Heart Lung
Impact factor1.73
Citation count3
Date of publishing2021 Jan-Feb
Testes autopsy of 3/6 COVID-19 positive men had abnormal spermatogenesis and higher levels of ACE-2 receptor expression.
PMID 33151050
Title Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis
Author(s) nameAchua JK, Chu KY, Ibrahim E, Khodamoradi K, Delma KS, Iakymenko OA, Kryvenko ON, Arora H, Ramasamy R.
Journal World J Mens Health
Impact factor
Citation count1
Date of publishing2021 Jan
Five out of 9 children with COVID 19 had only mild upper respiratory tract infection and the remaining 4 had pneumonia.
PMID 32515685
Title Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19
Author(s) nameLiu P, Cai J, Jia R, Xia S, Wang X, Cao L, Zeng M, Xu J.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count10
Date of publishing2020 Dec
The CT scan results of 92 patients with novel coronavirus-infected pneumonia (NCIP) were analyzed using a quantitative, computer-based and semiquantitative scoring system. The two different radiological scores correlated with each other and with several clinical, laboratory features, and the CALL score.
PMID 33144492
Title Chest Computed Tomography Scoring in Patients With Novel Coronavirus-infected Pneumonia: Correlation With Clinical and Laboratory Features and Disease Outcome
Author(s) namePugliese L, Sbordone FP, Grimaldi F, Ricci F, DI Tosto F, Spiritigliozzi L, DI Donna C, Presicce M, DE Stasio V, Benelli L, D'Errico F, Pasqualetto M, Legramante JM, Materazzo M, Pellicciaro M, Buonomo OC, Vanni G, Rizza S, Bellia A, Floris R, Garaci F, Chiocchi M.
Journal In Vivo
Impact factor
Citation count1
Date of publishing2020 Nov-Dec
An 11-year old boy, positive for SARS-CoV-2 infection, showed increased inflammation and coagulopathy with similar clinical features of incomplete KD (Kawasaki disease) or KD shock syndrome.
PMID 33169560
Title Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea
Author(s) nameKim H, Shim JY, Ko JH, Yang A, Shim JW, Kim DS, Jung HL, Kwak JH, Sol IS.
Journal J Korean Med Sci
Impact factor1.74
Citation count2
Date of publishing2020 Nov 9
The rate of severity of COVID-19 infection upon SARS-CoV-2/dengue virus co-infection was studied
PMID 33259817
Title Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever
Author(s) nameTeotônio IMSN, de Carvalho JL, Castro LC, Nitz N, Hagström L, Rios GG, de Fátima Rodrigues de Oliveira M, Dallago BSL, Hecht M.
Journal Acta Trop
Impact factor
Citation count1
Date of publishing2020 Nov 28
A 27 years old female, asymptomatic for SARS-CoV-2 infection, had morphological changes in the skin.
PMID 33139373
Title Chilblain-like lesions with prominent bullae in a patient with COVID-19
Author(s) nameRubin A, Alamgir M, Rubin J, Rao BK.
Journal BMJ Case Rep
Impact factor0.44
Citation count1
Date of publishing2020 Nov 2
Autopsies of 68 COVID-19 positive patients showed morphological changes in the lungs.
PMID 32879413
Title COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Author(s) nameBorczuk AC, Salvatore SP, Seshan SV, Patel SS, Bussel JB, Mostyka M, Elsoukkary S, He B, Del Vecchio C, Fortarezza F, Pezzuto F, Navalesi P, Crisanti A, Fowkes ME, Bryce CH, Calabrese F, Beasley MB.
Journal Mod Pathol
Impact factor6.19
Citation count17
Date of publishing2020 Nov
Autopsies of 68 COVID-19 positive patients showed Vascular injury in the Lungs
PMID 32879413
Title COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Author(s) nameBorczuk AC, Salvatore SP, Seshan SV, Patel SS, Bussel JB, Mostyka M, Elsoukkary S, He B, Del Vecchio C, Fortarezza F, Pezzuto F, Navalesi P, Crisanti A, Fowkes ME, Bryce CH, Calabrese F, Beasley MB.
Journal Mod Pathol
Impact factor6.19
Citation count17
Date of publishing2020 Nov
Autopsies of 68 COVID-19 positive patients showed patterns of acute respiratory distress syndrome and Organizing pneumonia.
PMID 32879413
Title COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Author(s) nameBorczuk AC, Salvatore SP, Seshan SV, Patel SS, Bussel JB, Mostyka M, Elsoukkary S, He B, Del Vecchio C, Fortarezza F, Pezzuto F, Navalesi P, Crisanti A, Fowkes ME, Bryce CH, Calabrese F, Beasley MB.
Journal Mod Pathol
Impact factor6.19
Citation count17
Date of publishing2020 Nov
Autopsies of 68 COVID-19 positive patients showed inflammation in the Airways (tracheobronchial), Alveolar space, and Alveolar wall.
PMID 32879413
Title COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
Author(s) nameBorczuk AC, Salvatore SP, Seshan SV, Patel SS, Bussel JB, Mostyka M, Elsoukkary S, He B, Del Vecchio C, Fortarezza F, Pezzuto F, Navalesi P, Crisanti A, Fowkes ME, Bryce CH, Calabrese F, Beasley MB.
Journal Mod Pathol
Impact factor6.19
Citation count17
Date of publishing2020 Nov
The study describes a case of malignant ischemic stroke in a middle-aged adult admitted with COVID-19 infection
PMID 33066910
Title Malignant Cerebral Ischemia in A COVID-19 Infected Patient: Case Review and Histopathological Findings
Author(s) namePatel SD, Kollar R, Troy P, Song X, Khaled M, Parra A, Pervez M.
Journal J Stroke Cerebrovasc Dis
Impact factor1.7
Citation count2
Date of publishing2020 Nov
Patients with suspected SARS-CoV-2 infection displaying cutaneous acral lesions resembling chilblains were studied. Histopathology studies revealed a a chilblain-like histopathological pattern and a thrombotic vasculopathy pattern.
PMID 33036032
Title Histopathological features of Chilblain-like lesions developing in the setting of the COVID-19 pandemic
Author(s) nameSohier P, Matar S, Meritet JF, Laurent-Roussel S, Dupin N, Aractingi S.
Journal Arch Pathol Lab Med
Impact factor4.27
Citation count2
Date of publishing2020 Oct 9
The clinical characteristics and manifestations of older patients with coronavirus disease 2019 (COVID-19) was assessed and their risk factors were compared with other age groups. Older patients are most likely to exhibit systemic inflammation, pulmonary and extrapulmonary organ damage and a higher mortality.
PMID 33032534
Title Clinical characteristics and manifestations in older patients with COVID-19
Author(s) nameWei C, Liu Y, Liu Y, Zhang K, Su D, Zhong M, Meng X.
Journal BMC Geriatr
Impact factor
Citation count4
Date of publishing2020 Oct 8
Chest X-ray of COVID-19 patients (average age 48 years) who also suffered from severe bronchospasm.
PMID 33173630
Title Decreased Mortality in Patients With Severe Bronchospasm Associated With SARS-CoV-2: An Alternative to Invasive Mechanical Ventilation
Author(s) nameSalazar R Sr, Hallo A, Vasquez S, Reinthaller S, Echeverria J.
Journal Cureus
Impact factorCant find
Citation count1
Date of publishing2020 Oct 6
A 35-year-old pregnant woman, positive for SARS-CoV-2 infection, had neurological complications and showed sudden blindness after childbirth.
PMID 33023500
Title SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report
Author(s) nameGarcia Rodriguez A, Marcos Contreras S, Fernandez Manovel SM, Marcos Vidal JM, Diez Buron F, Fernandez Fernandez C, Riveira Gonzalez MDC.
Journal BMC Pregnancy Childbirth
Impact factor2.65
Citation count1
Date of publishing2020 Oct 6
Lung pathophysiological data from chest CT findings were used for predicting progressive risk of COVID-19 in patients.
PMID 33009413
Title Early prediction of disease progression in COVID-19 pneumonia patients with chest CT and clinical characteristics
Author(s) nameFeng Z, Yu Q, Yao S, Luo L, Zhou W, Mao X, Li J, Duan J, Yan Z, Yang M, Tan H, Ma M, Li T, Yi D, Mi Z, Zhao H, Jiang Y, He Z, Li H, Nie W, Liu Y, Zhao J, Luo M, Liu X, Rong P, Wang W.
Journal Nat Commun
Impact factor11.8
Citation count11
Date of publishing2020 Oct 2
A 52-year old man admitted to the hospital for abdominal pain showed spontaneous splenic rupture. The patient was later confirmed to be COVID-19 postive, Hence, spontaneous splenic rupture is a type of risk that should be considered in COVID-19 patients.
PMID 33008424
Title The presentation of spontaneous splenic rupture in a COVID-19 patient: a case report
Author(s) nameMobayen M, Yousefi S, Mousavi M, Shafighi Anbaran A.
Journal BMC Surg
Impact factor1.73
Citation count1
Date of publishing2020 Oct 2
Histopathology of skin biopsies from 7 COVID-19 Chilblains ('COVID toes') showed lymphocytic vasculitis, fibrinoid necrosis and thrombosis. endothelial cells and epithelial cells of eccrine glands were positive for SARS-CoV-2 and viral particles were found in the cytoplasm of endothelial cells.
PMID 32562567
Title SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases
Author(s) nameColmenero I, Santonja C, Alonso-Riaño M, Noguera-Morel L, Hernández-Martín A, Andina D, Wiesner T, Rodríguez-Peralto JL, Requena L, Torrelo A.
Journal Br J Dermatol
Impact factor6.22
Citation count39
Date of publishing2020 Oct