Pathophysiology


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An acute lung injury model by intratracheally instilling the S1 subunit of SARS-CoV-2 Spike S protein (400 µg/kg, 2 ml/kg body weight) in K18-hACE2 transgenic mice that overexpress the human receptor for SARS-CoV-2 Spike protein S, ACE2, and investigated outcomes 72 hours later.
PMID
Title Single intratracheal exposure to SARS-CoV-2 S1 spike protein induces acute lung injury in K18-hACE2 transgenic mice
Author(s) namePavel Solopov, Ruben Colunga Biancatelli, Elizabeth Sharlow, John Lazo, John Catravas
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Lung samples from 12 COVID-19 victims were assessed. The main site of viral replication was the pulmonary alveoli wherein most of the coagulatory events also occurred. Accumulation of CD163+ macrophages and the disappearance of T cells, B cells and NK cells were some of the inflammatory responses.
PMID
Title Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of Covid-19 death
Author(s) name-
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Findings from 3-dimensional histological imaging of lung sample from a COVID-19 victim were reported. Pulmonary microangiopathy that involved activated megakaryocyte in the lungs were found to be the major cause of death.
PMID
Title Multiscale 3-dimensional pathology findings of COVID-19 diseased lung using high-resolution cleared tissue microscopy
Author(s) name-
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Five patients who were tested positive for COVID-19 showing clinical features for pulmonary thromboembolism (PTE), resulting in the death of two of the patients. The average time for the onset of PTE was 2-4 weeks.
PMID 33075608
Title The clinical spectrum of pulmonary thromboembolism in patients with coronavirus disease-2019 (COVID-19) pneumonia: A European case series
Author(s) nameSakr Y, Giovini M, Leone M, Pizzilli G, Kortgen A, Bauer M, Tonetti T, Duclos G, Zieleskiewicz L, Buschbeck S, Ranieri VM, Antonucci E.
Journal J Crit Care
Impact factor2.83
Citation count1
Date of publishing2021 Feb
A 47-year-old COVID-19 patient devloped pneumonia along with Guillain-Barr Syndrome (GBS). Blood test revealed increased levels of IL-6 and aldosterone indicating primary aldosteronism.
PMID 32749708
Title Can aldosterone increase interleukin-6 levels in Covid-19 pneumonia?
Author(s) nameCampana P, Flocco V, Aruta F, Cacciatore F, Abete P.
Journal J Med Virol
Impact factor2.07
Citation count1
Date of publishing2021 Feb
In critically ill COVID-19 patients, a decrease in Diaphramatic thickening fraction (DTF) can be used to predict the failure of continuous positive airway pressure (CPAP) and requirement of invasive ventilation.
PMID 33197604
Title Diaphragmatic thickening fraction as a potential predictor of response to continuous positive airway pressure ventilation in Covid-19 pneumonia: A single-center pilot study
Author(s) nameCorradi F, Vetrugno L, Orso D, Bove T, Schreiber A, Boero E, Santori G, Isirdi A, Barbieri G, Forfori F.
Journal Respir Physiol Neurobiol
Impact factor1.55
Citation count1
Date of publishing2021 Feb
Sublingual microcirculation was assessed in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome(ARDS). Sublingual microcirculation was characterized by decreases in the proportion of perfused vessel and flow velocity, along with high vascular densities,which may indicate enhanced angiogenesis or hypoxia-induced capillary recruitment.
PMID 33096349
Title Microcirculation alterations in severe COVID-19 pneumonia
Author(s) nameKanoore Edul VS, Caminos Eguillor JF, Ferrara G, Estenssoro E, Siles DSP, Cesio CE, Dubin A.
Journal J Crit Care
Impact factor2.83
Citation count2
Date of publishing2021 Feb
A combination of mechanical ventilation(MV) and Extracorporeal membrane oxygenation (ECMO) was used to treat a pregnant female with COVID-19 with Acute respiratory distress syndrome (ARDS) successfully.
PMID 32948334
Title First successful treatment of a COVID-19 pregnant woman with severe ARDS by combining early mechanical ventilation and ECMO
Author(s) nameHou L, Li M, Guo K, Wang W, Li B, Li J, Yuan Y.
Journal Heart Lung
Impact factor1.73
Citation count3
Date of publishing2021 Jan-Feb
Testes autopsy of 3/6 COVID-19 positive men had abnormal spermatogenesis and higher levels of ACE-2 receptor expression.
PMID 33151050
Title Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis
Author(s) nameAchua JK, Chu KY, Ibrahim E, Khodamoradi K, Delma KS, Iakymenko OA, Kryvenko ON, Arora H, Ramasamy R.
Journal World J Mens Health
Impact factor
Citation count1
Date of publishing2021 Jan
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with bafilomycin A1.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
The in vitro mutation analysis showed that the D614G mutation changes the spike protein sorting, enhances the trafficking of spike protein to the lysosome.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline and dynasore.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline and pitstop2.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with nocodazole.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
The Growth properties of Del-mut-1 variant and WT viruses in Vero-E6, A549, Caco-2, and Calu-3 cells showed stability and increased population along the passages only in the Vero-E6 cells
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
The virus titers in the tracheal and lung tissues of infected Hamsters showed higher virus replication in the lung tissues of hamsters infected with WT SARS-CoV-2 than Del-mut-1 variant infected hamsters.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
Five out of 9 children with COVID 19 had only mild upper respiratory tract infection and the remaining 4 had pneumonia.
PMID 32515685
Title Dynamic surveillance of SARS-CoV-2 shedding and neutralizing antibody in children with COVID-19
Author(s) nameLiu P, Cai J, Jia R, Xia S, Wang X, Cao L, Zeng M, Xu J.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count10
Date of publishing2020 Dec
4 Hamsters infected with Del-mut-1 SARS-CoV-2 viruses showed diffuse alveolar wall thickening and peribronchiolar infiltration in the lungs and no bodyweight loss.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
Metagenomics analysis of three samples from Taiwan revealed the co-existence of Haemophilus parainfluenzae.
PMID 32543353
Title SARS-CoV-2 genomic surveillance in Taiwan revealed novel ORF8-deletion mutant and clade possibly associated with infections in Middle East
Author(s) nameGong YN, Tsao KC, Hsiao MJ, Huang CG, Huang PN, Huang PW, Lee KM, Liu YC, Yang SL, Kuo RL, Chen KF, Liu YC, Huang SY, Huang HI, Liu MT, Yang JR, Chiu CH, Yang CT, Chen GW, Shih SR.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count22
Date of publishing2020 Dec
4 Hamsters infected with WT SARS-CoV-2 viruses (Wuhan-1) showed extensive alveolar wall destruction, alveolar space haemorrhage, and mononuclear cell infiltration in the lungs and bodyweight loss.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
The CT scan results of 92 patients with novel coronavirus-infected pneumonia (NCIP) were analyzed using a quantitative, computer-based and semiquantitative scoring system. The two different radiological scores correlated with each other and with several clinical, laboratory features, and the CALL score.
PMID 33144492
Title Chest Computed Tomography Scoring in Patients With Novel Coronavirus-infected Pneumonia: Correlation With Clinical and Laboratory Features and Disease Outcome
Author(s) namePugliese L, Sbordone FP, Grimaldi F, Ricci F, DI Tosto F, Spiritigliozzi L, DI Donna C, Presicce M, DE Stasio V, Benelli L, D'Errico F, Pasqualetto M, Legramante JM, Materazzo M, Pellicciaro M, Buonomo OC, Vanni G, Rizza S, Bellia A, Floris R, Garaci F, Chiocchi M.
Journal In Vivo
Impact factor
Citation count1
Date of publishing2020 Nov-Dec
An 11-year old boy, positive for SARS-CoV-2 infection, showed increased inflammation and coagulopathy with similar clinical features of incomplete KD (Kawasaki disease) or KD shock syndrome.
PMID 33169560
Title Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea
Author(s) nameKim H, Shim JY, Ko JH, Yang A, Shim JW, Kim DS, Jung HL, Kwak JH, Sol IS.
Journal J Korean Med Sci
Impact factor1.74
Citation count2
Date of publishing2020 Nov 9
Necessity of detection of trichomonads in patients with COVID-19
PMID 33271170
Title SARS-CoV-2 and superimposed infection by trichomonads
Author(s) nameDuboucher C.
Journal J Infect
Impact factor5.1
Citation count1
Date of publishing2020 Nov 30
The rate of severity of COVID-19 infection upon SARS-CoV-2/dengue virus co-infection was studied
PMID 33259817
Title Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever
Author(s) nameTeotônio IMSN, de Carvalho JL, Castro LC, Nitz N, Hagström L, Rios GG, de Fátima Rodrigues de Oliveira M, Dallago BSL, Hecht M.
Journal Acta Trop
Impact factor
Citation count1
Date of publishing2020 Nov 28