Drug studies in animals
Last updated: 2021 Sep 7
Total hit(s): 28
S.No.
1
33691601
The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract
Emerg Microbes Infect
2021 Dec
5.84
3
2
33538646
Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection
Emerg Microbes Infect
2021 Dec
5.84
1
3
34340553
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19
mBio
2021 Aug 31
6.5
1
4
34268511
Evaluation of intranasal nafamostat or camostat for SARS-CoV-2 chemoprophylaxis in Syrian golden hamsters
bioRxiv
2021 Jul 8
Its not a journal
1
5
34210738
Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection
Proc Natl Acad Sci U S A
2021 Jul 20
9.35
1
6
34269012
Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats
J Zhejiang Univ Sci B
2021 Jul 15
2.03
1
7
34226102
Laser-facilitated epicutaneous immunization of mice with SARS-CoV-2 spike protein induces antibodies inhibiting spike/ACE2 binding
Vaccine
2021 Jun 26
3.31
1
8
33813272
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
Biochem Biophys Res Commun
2021 May 28
2.73
3
9
33787221
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells
ACS Chem Biol
2021 Apr 16
2
10
33844653
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice
J Clin Invest
2021 Apr 12
10.51
1
11
33774649
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Signal Transduct Target Ther
2021 Mar 27
<3years
4
12
33639976
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice
Virol J
2021 Feb 27
2.45
1
13
33602867
SARS-CoV-2 M(pro) inhibitors with antiviral activity in a transgenic mouse model
Science
2021 Feb 18
20.57
2
14
33594371
Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures
bioRxiv
2021 Feb 15
Its not a journal
1
15
33523654
Remdesivir Metabolite GS-441524 Effectively Inhibits SARS-CoV-2 Infection in Mouse Models
J Med Chem
2021 Feb 1
6.26
1
16
33532765
Early therapy with remdesivir and antibody combinations improves COVID-19 disease in mice
bioRxiv
2021 Jan 28
Its not a journal
1
17
33262453
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models
Cell Res
2021 Jan
10.9
3
18
33330862
Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells
bioRxiv
2020 Dec 9
Its not a journal
4
19
33090972
Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models
JCI Insight
2020 Dec 3
6.014
1
20
32882638
Quantifying the effect of remdesivir in rhesus macaques infected with SARS-CoV-2
Virology
2020 Nov
2.819
1
21
33140046
A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells
bioRxiv
2020 Oct 30
Its not a journal
3
22
33037151
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity
Proc Natl Acad Sci U S A
2020 Oct 27
9.35
9
23
32516797
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Nature
2020 Sep
24.36
103
24
32577633
Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2
bioRxiv
2020 Jun 11
Its not a journal
3
25
32447523
Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines
Arch Toxicol
2020 Jun
5.66
8