Structure : Nsp9

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Original Article
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Structural characterisation of Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase 3C sequence forms sheet interactions with the N terminus of the protein from the other protomer, as a result N terminal residues move outward by 1.6 (residues 610). The significance of this is yet to be established.
32592996
(iScience)
PMID
32592996
Date of Publishing: 2020 Jul 24
Title Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
Author(s) nameLittler DR, Gully BS et al.
Journal iScience
Impact factor
4.447
Citation count: 73


Structural characterisation of SARS-CoV-2 Nsp9 RNA-replicase. The residues involved in protein binding in the hydrophobic cavity and the structural changes are highly conserved among other Nsp9 homologs. Established a protocol for the production and purification of SARS-CoV-2 Nsp9 protein.
32592996
(iScience)
PMID
32592996
Date of Publishing: 2020 Jul 24
Title Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
Author(s) nameLittler DR, Gully BS et al.
Journal iScience
Impact factor
4.447
Citation count: 73



Drugs : Nsp9

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Original Article
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Virtual screening of 2985 FDA approved drugs using in silico methods revealed 5 potential compounds (Alvesco, troglitazone, avodart, dihydroergotoxine, and fluspirilene) against SARS-CoV-2 NSP9. The PCA analysis result suggested that avodart formed a slightly more stable complex compared to the other complexes.
33491573
(J Biomol Struct Dyn)
PMID
33491573
Date of Publishing: 2021 Jan 25
Title Exploring potential inhibitor of SARS-CoV2 replicase from FDA approved drugs using insilico drug discovery methods
Author(s) nameChandra A, Gurjar V et al.
Journal J Biomol Struct Dyn
Impact factor
3.22
Citation count: 2
Date of Entry 2021 Sep 5



Molecular_interactions : Nsp9

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Original Article
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Nsp13-1 stabilizes SARS-CoV-2 replication and transcription (RTC) complex by contacting with nsp13-2, which anchors the 5'-extension of RNA template, and interacting with nsp7-nsp8-nsp12-RNA. Different orientations of nsp13-1 results in different interactions with the two forms of mini RTC. Mini RTC with an nsp12R365A mutation has greater helicase activity compared to individual apsnsp13. Nsp13-1T216A mutation has a decreased helicase activity.
33208736
(Nat Commun)
PMID
33208736
Date of Publishing: 2020 Nov 18
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y et al.
Journal Nat Commun
Impact factor
11.8
Citation count: 49


Structural characterization of Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase. 3C sequence forms β sheet interactions with the N terminus of the protein from the other protomer, as a result N terminal residues move outward by ∼1.6 (residues 610). The significance of this is yet to be established.
32592996
(iScience)
PMID
32592996
Date of Publishing: 2020 Jul 24
Title Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
Author(s) nameLittler DR, Gully BS et al.
Journal iScience
Impact factor
4.447
Citation count: 73