Variants : Nsp6

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Original Article
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Phylogenetic analysis showed that the B.1.526 isolates can be branched into 3 sub-lineages, with 2 major lineages B.1.526-E484K and B.1.526-S477N containing A701V mutation and one smaller sub-lineage B.1.526-S477n containing Q957R mutation. Phylogenetic analyses of genomes containing a deletion (9bp deletion 106-108) in the non-spike region (ORF1a- nsp6) along with mutation A2262G clearly distinguishes the parent clade into B.1.526 variant and related viruses.
Pre-print ( medRXiv )
Date of Publishing 2021 Apr 15
Title A Novel and Expanding SARS-CoV-2 Variant, B.1.526, Identified in New York
Date of Entry 2021 Jul 2



Sequence : Nsp6

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Indian metadata was analyzed to associate the frequent mutations and co-mutation patterns with COVID-19 patient status (deceased, symptomatic, mild, and asymptomatic groups). Patient status was reported for only 806 sequences where 95 were marked as deceased, and 631, 49, 31 were marked as symptomatic, mild, and asymptomatic, respectively
Pre-print (bioRXiv)
Date of Publishing 2021 Mar 25
Title Genomic surveillance and phylodynamic analyses reveal emergence of novel mutation and co-mutation patterns within SARS-CoV2 variants prevalent in India
Author(s) nameNupur Biswas, Priyanka Mallick et al.
Date of Entry 2021 Jun 14



Immunology : Nsp6

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SARS-CoV-2 spike-specific CD8+ and CD4++ T cells were detected in 70% and 100% of COVID-19 convalescent cases, respectively. In addition to the M, spike and N protein, CD4++ T cell responses were also seen against ORF3a, ORF8, nsp3, and nsp4 proteins. SARS-CoV-2 RBD-specific IgG and IgA levels correlated with CD4++ T cell responses to spike protein. SARS-CoV-2-reactive CD4++ T cells were also detected in 40%-60% of unexposed individuals suggesting cross-reactive T cell recognition. "1.) Participant Characteristics: Table 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/table/tbl1/?report=objectonly) 2.) SARS-CoV-2 IgM, IgA, and IgG Responses of Recovered COVID-19 Patients: Figure 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig1/). 3.) SARS-CoV-2-Specific CD4+ T Cell Responses of Recovered COVID-19 Patients: Figure 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig2/) 4.) SARS-CoV-2-Specific CD8+ T Cell Responses by Recovered COVID-19 Patients: Figure 3 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig3/) 5.) Correlations between SARS-CoV-2-Specific CD4+ T Cells, Antibodies, and CD8+ T Cells: Figure 4 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig4/)"
32473127
(Cell)
PMID
32473127
Date of Publishing: 2020 Jun 25
Title Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
Author(s) nameGrifoni A, Weiskopf D et al.
Journal Cell
Impact factor
27.35
Citation count: 1309
Date of Entry 2021 Jul 24