New_variants : Nsp6

Total row(s): 1
Select item(s)
Key Findings
Original Article
(hover to see details)
Phylogenetic analysis showed that the B.1.526 isolates can be branched into 3 sub-lineages, with 2 major lineages B.1.526-E484K and B.1.526-S477N containing A701V mutation and one smaller sub-lineage B.1.526-S477n containing Q957R mutation. -
()
PMID
-
Date of Publishing: 2021 Apr 15
Title A Novel and Expanding SARS-CoV-2 Variant, B.1.526, Identified in New York
Date of Entry 18_37_51 Jul

Sequence : Nsp6

Total row(s): 1
Select item(s)
Key Findings
Original Article
(hover to see details)
Indian metadata was analyzed to associate the frequent mutations and co-mutation patterns with COVID-19 patient status (deceased, symptomatic, mild, and asymptomatic groups). Pre-print (bioRXiv)
Date of Publishing 2021 Mar 25
Title Genomic surveillance and phylodynamic analyses reveal emergence of novel mutation and co-mutation patterns within SARS-CoV2 variants prevalent in India
Author(s) nameNupur Biswas, Priyanka Mallick et al.
Date of Entry 2021 Jun 14

Immunology : Nsp6

Total row(s): 1
Select item(s)
Key Findings
Original Article
(hover to see details)
SARS-CoV-2 spike-specific CD8+ and CD4+ T cells were detected in 70% and 100% of COVID-19 convalescent cases, respectively. In addition to the M, spike and N protein, CD4+ T cell responses were also seen against ORF3a, ORF8, nsp3, and nsp4 proteins. SARS-CoV-2 RBD-specific IgG and IgA levels correlated with CD4+ T cell responses to spike protein. SARS-CoV-2-reactive CD4+ T cells were also detected in 40%-60% of unexposed individuals suggesting cross-reactive T cell recognition. 32473127
(Cell)
PMID
32473127
Date of Publishing: 2020 Jun 25
Title Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
Author(s) nameGrifoni A, Weiskopf D et al.
Journal Cell
Impact factor
27.35
Citation count: 392
Date of Entry 2021 Jul 24