Sequence : Nsp4

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Original Article
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Comparative variant analysis of genome sequences of eleven Lebanese SARS-CoV-2 isolates revealed forty unique missense variants. Of forty unique variants identified, eighteen were new mutations.
33091548
(Genomics)
PMID
33091548
Date of Publishing: 2020 Oct 20
Title Variant analysis of the first Lebanese SARS-CoV-2 isolates.
Author(s) nameAbou-Hamdan M, Hamze K et al.
Journal Genomics
Impact factor
3.9
Citation count: 4



Immunology : Nsp4

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Original Article
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SARS-CoV-2 spike-specific CD8+ and CD4++ T cells were detected in 70% and 100% of COVID-19 convalescent cases, respectively. In addition to the M, spike and N protein, CD4++ T cell responses were also seen against ORF3a, ORF8, nsp3, and nsp4 proteins. SARS-CoV-2 RBD-specific IgG and IgA levels correlated with CD4++ T cell responses to spike protein. SARS-CoV-2-reactive CD4++ T cells were also detected in 40%-60% of unexposed individuals suggesting cross-reactive T cell recognition. "1.) Participant Characteristics: Table 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/table/tbl1/?report=objectonly) 2.) SARS-CoV-2 IgM, IgA, and IgG Responses of Recovered COVID-19 Patients: Figure 1 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig1/). 3.) SARS-CoV-2-Specific CD4+ T Cell Responses of Recovered COVID-19 Patients: Figure 2 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig2/) 4.) SARS-CoV-2-Specific CD8+ T Cell Responses by Recovered COVID-19 Patients: Figure 3 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig3/) 5.) Correlations between SARS-CoV-2-Specific CD4+ T Cells, Antibodies, and CD8+ T Cells: Figure 4 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237901/figure/fig4/)"
32473127
(Cell)
PMID
32473127
Date of Publishing: 2020 Jun 25
Title Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
Author(s) nameGrifoni A, Weiskopf D et al.
Journal Cell
Impact factor
27.35
Citation count: 1309
Date of Entry 2021 Jul 24