Transcriptomics


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Original Article
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The transcriptomic profiling of ACE2 across 13 tissues (119 cell types) reveals that ACE2 expresses in lung AT2, liver cholangiocyte, colon colonocytes, esophagus keratinocytes, ileum ECs, rectum ECs, stomach epithelial cells, and kidney proximal tubules. The low expression of ACE2 in the lung raises the possibility of existence of co-receptors facilitating nCoV infection.
32199615
(Biochem Biophys Res Commun)
PMID
32199615
Date of Publishing: 2020 May 21
Title Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
Author(s) nameQi F, Qian S et al.
Journal Biochem Biophys Res Commun
Impact factor
2.73
Citation count: 175


The single-cell co-expression profiling of 451 genes across the 13 human tissues (119 cell types) reveals that 94 genes are co-expressed with ACE2. Of those, ANPEP, ENPEP, and DPP4 are the top three genes correlated with ACE2. The result suggests that CoVs infect similar types of cells and CoV-infected patients share similar clinical symptoms.
32199615
(Biochem Biophys Res Commun)
PMID
32199615
Date of Publishing: 2020 May 21
Title Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
Author(s) nameQi F, Qian S et al.
Journal Biochem Biophys Res Commun
Impact factor
2.73
Citation count: 175


"CellPhoneDB" analysis revealed that the nCoV-targeted cells (ACE2-expressing) interact with several cell types in different tissues, especially macrophages in the lung, liver, and stomach, through CD74-MIF interaction and other signaling pathways. Other than MIF gene, PROs, SCs and TAs showed high interactions in the ACE2-expressing cells in ileum and rectum.
32199615
(Biochem Biophys Res Commun)
PMID
32199615
Date of Publishing: 2020 May 21
Title Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses
Author(s) nameQi F, Qian S et al.
Journal Biochem Biophys Res Commun
Impact factor
2.73
Citation count: 175


Respiratory tract scRNA-seq data analysis showed that pulmonary AT2 cells and respiratory epithelial cells had high ACE2 expression. The nasal and bronchial samples showed no ACE2 expression. Thus, the lungs are considered a high-risk organ for SARS-CoV-2 infections. Lungs were identified as the most vulnerable organ for SARS-CoV-2 infection, according to ACE2 expression. The cluster of cells with ACE2 expression also expressed canonical markers of respiratory epithelial cells PIGR and MUC1
32170560
(Front Med)
PMID
32170560
Date of Publishing: 2020 Apr
Title Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
Author(s) nameZou X, Chen K et al.
Journal Front Med
Impact factor
3
Citation count: 422


Heart scRNA-seq data analysis showed myocardial cells had high ACE2 expression levels. The presence of the virus in blood or viremia may cause SARS-CoV-2 infection in the heart. The cluster of cells with high ACE2 expression levels also expressed canonical markers of myocardial cells MYL3 and MYH7
32170560
(Front Med)
PMID
32170560
Date of Publishing: 2020 Apr
Title Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
Author(s) nameZou X, Chen K et al.
Journal Front Med
Impact factor
3
Citation count: 422


Digestive system scRNA-seq data analysis showed high ACE2 expression in Ileum and esophagus epithelial cells. Stomach and liver cells showed lower ACE2 expression levels. The findings explain non-respiratory symptoms (eg. diarrhea) associated with SARS-CoV-2. The cluster of ileum cells with high ACE2 expression also expressed canonical markers of ileal epithelial cells, FABP6, and ANPEP
32170560
(Front Med)
PMID
32170560
Date of Publishing: 2020 Apr
Title Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
Author(s) nameZou X, Chen K et al.
Journal Front Med
Impact factor
3
Citation count: 422


Urinary system scRNA-seq data analysis showed high ACE2 expression in Proximal tubule cells of kidney and bladder urothelial cells. The cluster of Kidney cells with high ACE2 expression also expressed canonical markers of kidney PT cells CUBN and LRP2. The cluster of bladder cells with high ACE2 expression also expressed canonical markers of bladder urothelial cells CLDN4 and SPINK1.
32170560
(Front Med)
PMID
32170560
Date of Publishing: 2020 Apr
Title Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection
Author(s) nameZou X, Chen K et al.
Journal Front Med
Impact factor
3
Citation count: 422