Clinical features


Last updated: 2021 Dec 15
Total hit(s): 82
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Original Article
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Serial pulmonary function, exercise capacity, and chest high-resolution CT (HRCT) changes in non-intubated patients hospitalised with severe COVID-19 pneumonia are reported in this study at 3 months, 6 months, 9 months, and 12 months after hospital discharge. Despite the fact that most patients' exercise ability improved over time, evidence of persisting physiological and radiographic alterations in a subset of individuals was discovered. No patient had a history of comorbidities or smoking.Pulmonary function tests were done according to American Thoracic Society (ATS)European Respiratory Society guidelines.Patients underwent chest non-contrast enhanced CT examinations in the supine position and with breath-holding following inspiration.6MWD test was done according to the ATS practical guidelines.The severity of dyspnoea was measured using an mMRC scale.
33964245
(Lancet Respir Med)
PMID
33964245
Date of Publishing: 2021 May 5
Title 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Author(s) nameWu X, Liu X et al.
Journal Lancet Respir Med
Impact factor
15.78
Citation count: 50
Date of Entry 2021 Dec 15


Higher in-hospital mortality was linked to both greater Blood urea nitrogen (BUN) upon admission and increased BUN within the first 24 hours. COVID-19 infected patients were found to have an increase in BUN at 24 hours of hospitalization, linked to a composite of clinical outcomes and in-hospital mortality.
33583325
(Ren Fail)
PMID
33583325
Date of Publishing: 2021 Dec
Title Association between an increase in blood urea nitrogen at 24h and worse outcomes in COVID-19 pneumonia
Author(s) nameYe B, Deng H et al.
Journal Ren Fail
Impact factor
1.68
Citation count: 1
Date of Entry 2021 Nov 1


Covid-19 infected patients were analyzed for Pulmonary embolism(PE) and D-dimer levels. Highest frequency of PE was found in ICU patients, most commonly in the peripheral region. Moreover, D-dimer value was higher in Covid-19 infected PE patients.
33966132
(Eur Radiol)
PMID
33966132
Date of Publishing: 2021 May 9
Title Pulmonary embolism in patients with COVID-19 and value of D-dimer assessment: a meta analysis.
Author(s) name Kwee RM, Adams HJA, Kwee TC.
Journal Eur Radiol
Impact factor
3.11
Citation count: 6
Date of Entry 2021 Nov 1


Lung ultrasound and Computed Tomography (CT) were compared to check their ability to diagnose COVID-19. Although Lung Ultra sound (LUS) could diagnose COVID-19 there was only a moderate correlation with CT findings as for lesion patterns and severity quantification 145 patients(66%) had pre-existing pathologies including cardiovascular diseases, active neoplastic disease and chronic kidney disease.
33743491
(Eur J Radiol)
PMID
33743491
Date of Publishing: 2021 May
Title Correlation between lung ultrasound and chest CT patterns with estimation of pulmonary burden in COVID-19 patients
Author(s) nameRizzetto F, Perillo N et al.
Journal Eur J Radiol
Impact factor
3.11
Citation count: 3
Date of Entry 2021 Nov 1


In non-critical COVID-19 patients, a blockage in the pulmonary (lung) artery was detected on Computer Tomography Pulmonary Angiography (CTPA). Daignostic tools such as D-dimer levels were not useful in precticitng the presence of Acute pulmonary embolism (APE). Heparin was used as an anticoagulant in 73% patients before conducting the Computer Tomography Pulmonary Angiography(CTPA).
33834578
(Intern Med J)
PMID
33834578
Date of Publishing: 2021 Apr 8
Title Acute pulmonary embolism in patients presenting pulmonary deterioration after hospitalisation for non-critical Covid-19.
Author(s) namePolo Friz H, Gelfi E et al.
Journal Intern Med J
Impact factor
1.75
Citation count: 2
Date of Entry 2021 Nov 1


The incidence of Deep vein thrombosis(DVT) and Pulmonary embolism(PE) was significantly higher in hopsialized COVID-19 patients when compared to non-COVID-19 individuals. Patients with DVT and PE had comparatively higher mortality rate, longer hospital stay and ICU when compared to the non-infected patients.
33836287
(J Vasc Surg Venous Lymphat Disord)
PMID
33836287
Date of Publishing: 2021 Apr 6
Title Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019- positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system.
Author(s) nameErben Y, Franco-Mesa C et al.
Journal J Vasc Surg Venous Lymphat Disord
Impact factor
2.11
Citation count: 4
Date of Entry 2021 Nov 1


Patients with pleural complications of Covid-19 pneumonia have a very high death rate. In critically ill patients with COVID-19 pneumonia, pneumothorax is a serious event.
33890447
(Turk J Med Sci)
PMID
33890447
Date of Publishing: 2021 Apr 23
Title The analysis of pleural complications of COVID-19 pneumonia.
Author(s) nameTürk MŞ, Akarsu I et al.
Journal Turk J Med Sci
Impact factor
0.62
Citation count: 1
Date of Entry 2021 Nov 1


In a newborn with COVID-19, COVID19 associated coagulopathy (CAG) may have led to the development of pulmonary artery thrombosis.There was an increase in the levels of anti-inflammatory cytokines-Interleukins (IL)-10 and IL-8.
33956761
(Pediatr Infect Dis J)
PMID
33956761
Date of Publishing: 2021 Jun 1
Title Pulmonary Artery Thrombosis in a Newborn With Severe Coronavirus Disease 2019
Author(s) nameSchulze-Schiappacasse C, Alarcón-Andrade G et al.
Journal Pediatr Infect Dis J
Impact factor
2.17
Citation count: 1
Date of Entry 2021 Sep 5


The study identifies adrenal hemorrhage as one of the possible complications of COVID-19. The physiological stress of severe COVID-19 combined with anti-coagulant therapy most likely led to adrenal hemorrhage. The patient suffered a cardiac arrest on Day 5. An echocardiogramgram (ECG) showed the dilated right ventricle with interventricular septal bulging and severe tricuspid regurgitation.
33815638
(Radiol Case Rep)
PMID
33815638
Date of Publishing: 2021 Jun
Title Bilateral adrenal hemorrhage in a man with severe COVID-19 pneumonia
Author(s) name Elkhouly MMN, Elazzab AA, Moghul SS.
Journal Radiol Case Rep
Impact factor
0.6
Citation count: 3
Date of Entry 2021 Sep 5


Gastrointestinal samples from COVID-19 patients who had undergone gastrointestinal procedures were analysed by histopathology and in situ hybridisation (ISH). The findings were either normal with the presence of virus detected by ISH and next-generation sequencing (NGS) or bowel ischemia without the presence of viral particles in the tissue.
33961007
(Arch Pathol Lab Med)
PMID
33961007
Date of Publishing: 2021 May 7
Title Pathophysiology,human,clinical features.
Author(s) nameWesterhoff M, Jones D et al.
Journal Arch Pathol Lab Med
Impact factor
4.27
Citation count: 3
Date of Entry 2021 Sep 5


Lungs of Covid-19 patients and patients who died of influenza were compared with uninfected lungs. Alveolar damage with perivascular T cell infiltration was the predominant feature in the infected lungs. Lungs from COVID-19 infected lungs also showed severe endothelial injury with the presence of intracellular virus. A multiplexed analysis showed that a total of 69 angiogenesis-related genes were differentilly regulated only in covid-19 group, when compared to 26 in the influenza group. 45 genes had shared changes in expression.
32437596
(N Engl J Med)
PMID
32437596
Date of Publishing: 2020 Jul 9
Title Pulmonary Vascular Endothelialitis,Thrombosis and Angiogenesis in Covid-19.
Author(s) nameAckermann M, Verleden SE et al.
Journal N Engl J Med
Impact factor
37.91
Citation count: 1866
Date of Entry 2021 Sep 5


Blood coagulation data in patients with COVID-19 infection was assessed. Compared to the healthy controls, the anti-thrombin values in COVID-19 patients were lower. The levels of D-dimer, fibrin/fibrinogen degradation products (FDP) and fibrinogen (FIB) was higher in the COVID-19 patients when compared to healthy controls.
32172226
(Clin Chem Lab Med)
PMID
32172226
Date of Publishing: 2020 Jun 25
Title Prominent changes in blood coagulation of patients with SARS-CoV-2 infection
Author(s) nameHan H, Yang L et al.
Journal Clin Chem Lab Med
Impact factor
3.59
Citation count: 487
Date of Entry 2021 Sep 5


A patient infected with Covid-19 pneumonia, developed severe hypoxia during hospitalisation. Extensive accumulation of air was seen in the centre of the chest (pneumodiastinum) extending into soft tissue around the neck and mediastinal spaces of the heart.
33948800
(J Gen Intern Med)
PMID
33948800
Date of Publishing: 2021 May 4
Title Spontaneous Pneomodiastinum in a patient with Covid-19 pneumonia.
Author(s) name Alavian N, Stephens JR, DeWalt DA.
Journal J Gen Intern Med
Impact factor
2.39
Citation count: 1
Date of Entry 2021 Sep 29


Acute kidney injury and/or heavy proteinuria was observed in COVID-19 patients with mild symptoms. The majority of these patients developed irreparable renal damage and required dialysis. Weeks after getting COVID-19, two of the three transplant recipients developed active antibody-mediated rejection. Since majority of the patients had mild symptoms, the kidney disease was managed with diuretics and blood pressure control. 7/12 patients showed improvement and 8 patients required dialysis.
33045255
(Am J Kidney Dis)
PMID
33045255
Date of Publishing: 2021 Jan
Title Multicenter Clinicopathologic Correlation of Kidney Biopsies Performed in COVID-19 Patients Presenting With Acute Kidney Injury or Proteinuria
Author(s) nameAkilesh S, Nast CC et al.
Journal Am J Kidney Dis
Impact factor
5.59
Citation count: 40
Date of Entry 2021 Sep 29


Pregnant women with SARS-CoV-2 infection who were asymptomatic reported miscarriage and pre-term labour, respectively. In both cases, the virus was found in the placenta using qRT-PCR. However, staining of the placental tissue did not show the presence of the virus.
33257773
(J Perinatol)
PMID
33257773
Date of Publishing: 2020 Nov 30
Title Detection of SARS-CoV-2 in placental but not fetal tissues in the second trimester
Author(s) nameValk JE, Chong AM et al.
Journal J Perinatol
Impact factor
3.6
Citation count: 5
Date of Entry 2021 Sep 29


Early diagnosis, evaluation of illness severity, and follow-up of patients with new coronavirus pneumonia require a high-resolution CT scan of the chest. The symptoms of new coronavirus pneumonia are varied and fast changing.
32055945
(Eur Radiol)
PMID
32055945
Date of Publishing: 2020 Jun
Title Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China
Author(s) namePan Y, Guan H et al.
Journal Eur Radiol
Impact factor
3.11
Citation count: 436
Date of Entry 2021 Sep 29


Plasma levels of Cathepsin L (CTSL), Cathepsin B (CTSB) were higher, and angiotensin 17 (Ang(17) level was lower in patients of Covid-19. Angiotensin-converting enzyme 2 (ACE2) level was the same in both infected and healthy individuals. Increased CTSL levels are associated with COVID-19.
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
N/A
Citation count: 38
Date of Entry 2021 Aug 23


Computed Tomography (CT) scan of a patient with covid-19 pneumonia showed both pleural effusion and pericardial effusion with enlargement of the heart. ECG test was reported negative for ischemic alterations. Vesicular murmur was reduced in both the lungs during auscultation done. The sO2 levels were 89%. Laboratory tests for the patient showed leukopenia, thrombopenia and an increased value of C-reactive protein.
33777279
(Radiol Case Rep)
PMID
33777279
Date of Publishing: 2021 Jun
Title Pericardial and pleural effusion in an elderly woman with Covid-19 pneumonia.
Author(s) nameMessina F, Turano L et al.
Journal Radiol Case Rep
Impact factor
0.6
Citation count: 1
Date of Entry 2021 Jul 24


Portable chest radiography[CXR] was performed on Covid-19 patients and the results were assessed to evaluate correlation with disease status and clinical outcomes. Initial CXR scores were found out to be associated with Covid-19 positivity, ICU admission and mechanical ventilation. CXR is more convinient than CT and rT-PCR,which has long turnaround time and high false-negative rate.
33706997
(Clin Radiol)
PMID
33706997
Date of Publishing: 2021 Jun
Title Initial chest radiograph scores inform Covid-19 status,intensive care unit admission and need for mechanical ventilation.
Author(s) nameShen B, Hoshmand-Kochi M et al.
Journal Clin Radiol
Impact factor
2.15
Citation count: 6
Date of Entry 2021 Jul 24


The study was done to assess the risk of developing Acute-on-chronic liver failure (ACLF) in cirrhosis patients after COVID-19 infection. Patients with SARS-CoV-2 related ACLF (S-ACLF) had prolonged hospital stay, severe illness and higher mortality when compared to patients without ACLF.
33398222
(J Clin Exp Hepatol)
PMID
33398222
Date of Publishing: 2021 May-Jun
Title Severe Acute Respiratory Syndrome Coronavirus2-related Acute-on-chronic Liver Failure.
Author(s) nameKumar P, Sharma M et al.
Journal J Clin Exp Hepatol
Impact factor
N/A
Citation count: 6
Date of Entry 2021 Jul 24


Autopsies, post-mortem CT scans along with histopathological and virological tests were performed on Covid-19 patients. Pulmonary embolism and Deep vein thrombosis were the major causes of death in most cases. Diffuse alveolar damage was found in 67% (8) patients. SARS-CoV-2 RNA was detected at high concentrations in the lungs. High viral titres were detected in the liver, kidney or heart of 5 patients. The most common co-morbid conditions were coronary heart disease and asthma or chronic obstructive pulmonary disease -50% and 25% respectively.
32374815
(Ann Intern Med)
PMID
32374815
Date of Publishing: 2020 Aug 18
Title Autopsy findings and venous Thromboembolism in patients with Covid-19.
Author(s) nameWichmann D, Sperhake JP et al.
Journal Ann Intern Med
Impact factor
11.75
Citation count: 990
Date of Entry 2021 Jul 24


This study shows direct evidence of SARS-CoV-2 into kidney tissue. Kidney abnormalities in autopsy patients showed proximal tubule injury with loss of brush border and necrosis. ACE2 protein was upregulated in the kidney and immunostaining showed the presence of SARS-CoV nucleoprotein in the tubules. Eleven patients had a history of hypertension or diabetes or both.
32327202
(Kidney Int)
PMID
32327202
Date of Publishing: 2020 Jul
Title Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China
Author(s) nameSu H, Yang M et al.
Journal Kidney Int
Impact factor
7.36
Citation count: 720
Date of Entry 2021 Jul 24


Chest CT scans showed that the lung abnormalities showed the highest severity 10 days after onset of symptoms in patients with COVID-19 pneumonia. Chest CTs started showing improvements approximately 14 days after the onset of initial symptoms.
32053470
(Radiology)
PMID
32053470
Date of Publishing: 2020 Jun
Title Time course of Lung changes at chest CT scans during recovery from Covid-19.
Author(s) namePan F, Ye T et al.
Journal Radiology
Impact factor
7.11
Citation count: 898
Date of Entry 2021 Jul 24


Chest CT scans of Symptomatic COVID-19 patients showed that early patients (0-2 days) had normal CT. As the disease progressed, the CT scans showed consolidation, bilateral and peripheral disease,"crazy paving" pattern and the "reverse halo". The CT findings are related to infection time course.
32077789
(Radiology)
PMID
32077789
Date of Publishing: 2020 Jun
Title Chest CT findings in Covid-19 and its relationship to duration of infection.
Author(s) nameBernheim A, Mei X et al.
Journal Radiology
Impact factor
7.11
Citation count: 972
Date of Entry 2021 Jul 24


Changes in the lungs like decreased lung sliding, pleural thickening and a B-profile were detectable by ultrasonography. Also, over the course of the disease, the pleura becomes thick and irregular, C-profile and pleural effusion becomes more prominent. Lung ultrasound findings in patients with severe acute respiratory syndrome-coronavirus-2 pneumonia.
33257915
(ERJ Open Res)
PMID
33257915
Date of Publishing: 2020 Oct
Title Lung ultrasound findings in patients with novel SARS-CoV-2
Author(s) nameHaaksma ME, Heldeweg MLA et al.
Journal ERJ Open Res
Impact factor
3.35
Citation count: 5
Date of Entry 2021 Jul 12