Protein - peptide

Last updated: 2021 Aug 12
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Original Article
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Based on the intermolecular contact maps (COCOMAPS tool) of ACE2-S complex structure, three short peptides (pep1c, pep1d, pep1e) were designed to block virus-host interaction in the early stages of SARS-CoV-2 infection. New therapeutics for oral administration against SARS-CoV-2 infection can be developed using these peptides, which could be an alternative to traditional drug development.
Date of Publishing: 2021 Apr 9
Title Native Structure-Based Peptides as Potential ProteinProtein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor
Author(s) nameOdolczyk N, Marzec E et al.
Journal Molecules
Impact factor
Citation count: 1
Date of Entry 2021 Aug 12

Structural characterization of Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase. 3C sequence forms β sheet interactions with the N terminus of the protein from the other protomer, as a result N terminal residues move outward by ∼1.6 Ć (residues 6–10). The significance of this is yet to be established.
Date of Publishing: 2020 Jul 24
Title Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9
Author(s) nameLittler DR, Gully BS et al.
Journal iScience
Impact factor
Citation count: 29