In vitro studies


Last updated: 2021 Aug 23
Total hit(s): 204
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SID 26681509 exhibits considerable cytotoxicity in Huh7 cells ~
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


Amantadine exhibits no cytotoxicity in Huh7cells Amantadine is a prophylactic agentinfluenza and for Parkinsons disease. It has been reported to suppress the gene transcription of CTSL
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


E64d exhibits no cytotoxicity in Huh7 cells. ~
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


SID 26681509 significantly inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells. SID 26681509 exhibits cytotoxicity, hence not used for further experiments.
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


Amantadine inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells by reducing the Cathepsin L (CTSL) enzyme activity. Amantadine can be used as a therapeutic.
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


E64d inhibits SARS-CoV-2 pseudovirus infection in Huh7 cells by reducing the Cathepsin L (CTSL) enzyme activity. E64d can be used as a therapeutic as it inhibits CTSL enzyme activity.
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


Cytotoxicity analysis of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into ACE2-expressed HEK293T cells by binding to the ACE2 receptor. Astemizole didn't influence the viability of ACE2 cells significantly. Astemizole can be re-used as a potential drug candidate in anti-coronavirus therapies
33932547
(Microb Pathog)
PMID
33932547
Date of Publishing: 2021 Apr 28
Title Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) nameWang X, Lu J et al.
Journal Microb Pathog
Impact factor
2.64
Citation count: 1
Date of Entry 2021 Aug 10


Antiviral efficacy of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into ACE2-expressed HEK293T cells by binding to the ACE2 receptor. SARS-COV-2 Spike pseudotype virus to enter the ACE2 cells were reduced significantly.
33932547
(Microb Pathog)
PMID
33932547
Date of Publishing: 2021 Apr 28
Title Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) nameWang X, Lu J et al.
Journal Microb Pathog
Impact factor
2.64
Citation count: 1
Date of Entry 2021 Aug 10


A mammalian cell-based assay was used to identify the coronavirus 3CL protease/pro inhibitors that does not require the use of live virus which demonstrated the assays utility that were highly concordant with the results from live virus testing and identified a set of key structural features shared among broadly active 3CLpro inhibitors. The data suggested that the assay could be applicable to other protease families, thus, representing a general platform for viral protease inhibitor studies. Because of the assays breadth and ease of use, it is well suited to form the backbone of a forward-thinking pandemic preparedness strategy. This would not only be capable of addressing the current human coronaviral strains but also provide the biomedical community with a series of high-value chemical leads to perform additional focused chemical optimization. These compounds could be further checked whether they have undergone preclinical testing for human use.
33910954
(J Virol)
PMID
33910954
Date of Publishing: 2021 Apr 28
Title Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity
Author(s) nameResnick SJ, Iketani S et al.
Journal J Virol
Impact factor
4.16
Citation count: 1
Date of Entry 2021 Aug 10


Type I PRMT inhibitor (MS023) inhibits interaction of N protein with the 5-UTR of SARS-CoV-2 genomic RNA, a property required for viral packaging. PRMT inhibitors, cancer drug canditates, have found to methylate arginine in the N protein, thereby regulating the SARS-CoV-2 lifecycle.
34029587
(J Biol Chem)
PMID
34029587
Date of Publishing: 2021 May 23
Title Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication
Author(s) nameCai T, Yu Z et al.
Journal J Biol Chem
Impact factor
3.96
Citation count: 1
Date of Entry 2021 Jul 28


Anti-viral activity of six drugs (arbidol, baloxavir, laninamivir, oseltamivir, peramivir, and zanamivir) against SARS-Co-V-2 was tested and among them only arbidol compound demonstrated to efficiently inhibit the virus infection in vitro. Further clinical studies on Arbidol should be done to check its efficacy and validate the recommended dosage to treat COVID-19 patients.
32373347
(Cell Discov)
PMID
32373347
Date of Publishing: 2020
Title The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
Author(s) nameWang X, Cao R et al.
Journal Cell Discov
Impact factor
4.65
Citation count: 52
Date of Entry 2021 Jun 15


In vitro activity of three Abl tyrosine kinase inhibitors- nilotinib, imatinib and dasatinib against SARS-CoV-2 was analysed in Vero-E6 and Calu-3 cells. The combinational therapy using antiviral and anti-inflammatory drugs is found to be one of the effective strategy to combat SARS-CoV-2.
33232578
(Basic Clin Pharmacol Toxicol)
PMID
33232578
Date of Publishing: 2020 Nov 24
Title The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 in vitro
Author(s) nameCagno V, Magliocco G et al.
Journal Basic Clin Pharmacol Toxicol
Impact factor
2.29
Citation count: 1


Antiviral activity of Naringenin against SARS-CoV-2 250 and 62.5 micromolar concentrations of Naringenin were very effective in protecting cells from SARS-CoV-2 infection.
33096221
(Pharmacol Res)
PMID
33096221
Date of Publishing: 2020 Oct 20
Title Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
Author(s) nameClementi N, Scagnolari C et al.
Journal Pharmacol Res
Impact factor
5.78
Citation count: 2


Invitro studies of chlorpheniramine shows strong virucidal effect against SARS-CoV-2 infected Vero cell line. CPM's antivirial and anti-inflammatory effects , with minimal side effects could be used in the early treatment and prevention of viral infections like influenzaA/B and COVID-19.
32963923
(Cureus)
PMID
32963923
Date of Publishing: 2020 Sep 17
Title In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2
Author(s) nameWestover JB, Ferrer G et al.
Journal Cureus
Impact factor
Cant find
Citation count: 3


Oxyclozanide showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells. Oxyclozanide showed IC50 of 3.71 micromolar un Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Ivacaftor showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells. Ivacaftor showed IC50 of 6.57 micromolar un Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Proscillaridin showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells. Proscillaridin showed IC50 of 2.04 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Tetrandrine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells. Tetrandrine showed IC50 of 3 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Berbamine hydrochloride showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells. Berbamine hydrochloride IC50 of 7.87 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Abemaciclib showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells. Abemaciclib showed IC50 of 6.62 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Cepharanthine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells. Cepharanthine showed IC50 of 4.47 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Ciclesonide showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells. Ciclesonide showed IC50 of 4.33 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Salinomycin sodium showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells. Salinomycin sodium IC50 of 0.24 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Mefloquine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells. Mefloquine showed IC50 of 4.33 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5


Lopinavir showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells. Lopinavir showed IC50 of 9.12 micromolar in Vero cells
32767684
(J Med Virol)
PMID
32767684
Date of Publishing: 2020 Aug 7
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S et al.
Journal J Med Virol
Impact factor
2.07
Citation count: 5