Cytotoxicity


Last updated: 2021 Aug 23
Total hit(s): 86
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Original Article
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SID 26681509 exhibits considerable cytotoxicity in Huh7 cells ~
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


Amantadine exhibits no cytotoxicity in Huh7cells Amantadine is a prophylactic agentinfluenza and for Parkinsons disease. It has been reported to suppress the gene transcription of CTSL
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


E64d exhibits no cytotoxicity in Huh7 cells. ~
33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
<3years
Citation count: 4
Date of Entry 2021 Aug 23


Cytotoxicity analysis of Astemizole which inhibits the entry of SARS-CoV-2 Spike pseudoviruses into ACE2-expressed HEK293T cells by binding to the ACE2 receptor. Astemizole didn't influence the viability of ACE2 cells significantly. Astemizole can be re-used as a potential drug candidate in anti-coronavirus therapies
33932547
(Microb Pathog)
PMID
33932547
Date of Publishing: 2021 Apr 28
Title Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro
Author(s) nameWang X, Lu J et al.
Journal Microb Pathog
Impact factor
2.64
Citation count: 1
Date of Entry 2021 Aug 10


Auranofin inhibited SARS-CoV-2 replication in Huh7 cells at CC50 5.7 micromolars.
32442105
(Virology)
PMID
32442105
Date of Publishing: 2020 Aug
Title The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
Author(s) nameRothan HA, Stone S et al.
Journal Virology
Impact factor
2.819
Citation count: 20


Cytotoxicity concentration of remdesivir (GS-5734) in Vero cells was >25 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of mefloquine in Vero cells was ~14 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of thioridazine hydrochloride in Vero cells was ~16 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Based on the cytopathic effect of the virus, chloroquine showed antiviral activity against SARS-CoV-2 at CC50 >37.5 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Based on the cytopathic effect of the virus, lopinavir showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Based on the cytopathic effect of the virus, remdesivir showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Based on the cytopathic effect of the virus, favipiravir showed antiviral activity against SARS-CoV-2 at CC50 >500 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Based on the cytopathic effect of the virus, atazanavir showed antiviral activity against SARS-CoV-2 at CC50 >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of Triparanol in Vero cells was ~15 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of proscillaridin in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of phenazopyridine hydrochloride in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of perhexiline maleate in Vero cells was ~9 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of penfluridol in Vero cells was ~9 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of oxyclozanide in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of ouabain in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of osimertinib mesylate in Vero cells was ~13 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of osajin in Vero cells was ~11 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of niclosamide in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of mequitazine in Vero cells was ~27 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119


Cytotoxicity concentration of salinomycin sodium in Vero cells was >50 micromolars.
32366720
(Antimicrob Agents Chemother)
PMID
32366720
Date of Publishing: 2020 Jun 23
Title Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs
Author(s) nameJeon S, Ko M et al.
Journal Antimicrob Agents Chemother
Impact factor
4.68
Citation count: 119