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Auto Summaries - Pathophysiology
Last updated: 2022 Jan 4
Total hit(s): 13622
S.No.
1
34931582
Symptoms at disease onset predict prognosis in COVID-19 disease
The main clinical manifestations of coronavirus disease 2019 (COVID-19) onset are respiratory symptoms, including cough, sputum, and dyspnea. However, a significant proportion of patients initially manifested non-respiratory symptoms, such as fever, myalgia, and diarrhea. Respiratory patients had more secondary bacterial infections, needed the intensive care unit more (9.7% vs 2.2%, P =0.005), developed ARDS more (11.4%) and needed longer time to recover (18.5 vs 16.7 days)
Libyan J Med
2022 Dec
1
2
34895104
Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value
Many COVID-19 infected people remain asymptomatic, and hence diagnosis at first presentation remains a challenge. Assessment at a presentation in primary care settings is usually done by visual triaging and basic clinical examination. This retrospective study involved investigating the medical e-records of patients who presented to a centre in Qatar for July 2020.
Libyan J Med
2022 Dec
1
3
34782556
SARS-CoV-2 involvement in central nervous system tissue damage
SARS-CoV-2 virus infects multiple organs including the brain. Patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. This overview attempts to give a thorough insight into SARS coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.
Neural Regen Res
2022 Jun
1
4
34931174
Striking lineage diversity of severe acute respiratory syndrome coronavirus 2 from non-human sources
From a set of 3595 publicly available SARS-CoV-2 genome sequences, 128 lineages were identified. Environment, Neovison vison, Odocoileus virginianus and Felis catus were the non-human sources with the highest number of lineages. Phylogenomic analyses showed viral clusters from environmental sources, including those from bats and pangolins.
One Health
2022 Jun
3.81
1
5
34677151
Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial
Coronavirus disease 2019 (COVID-19) pandemic has caused an urgent need for investigating potential treatments. Traditional medicine offers many potential remedies that have been historically used and have the advantage of bypassing the cultural obstacles in the practice of medicine. We aimed to investigate the efficacy of Zufa syrup in the treatment of suspected patients with mild to moderate symptoms of COVE-19.
Med Gas Res
2022 Apr-Jun
1
6
34677153
Ozone gas applied through nebulization as adjuvant treatment for lung respiratory diseases due to COVID-19 infections: a prospective randomized trial
The objective of this study was to provide lung disinfection by nebulizing ozone gas with distilled water and olive oil for patients who have clinical symptoms due to coronavirus disease 2019 (COVID-19) 30 patients who met the study criteria were prospectively evaluated. A statistically significant difference was found in the length of stay in hospital, change in C-reactive protein, polymerase chain reaction results after 5 days, and computed tomography scores between two groups.
Med Gas Res
2022 Apr-Jun
1
7
34677155
Acute asthma exacerbation after SARS-CoV-2 vaccine (SinovacĀ®): a case report
A 76-year-old female received a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (CoronaVac, Sinovac() and subsequently experienced chest discomfort. She was hospitalized with a preliminary diagnosis of drug-induced pneumonitis and acute asthma exacerbation. During her hospitalization, 40 mg/d systemic steroid, 4 times a day salbutamol nebulized, 2 L/min inhaled oxygen therapy and 400mg/d moxifloxacin intravenous were administered for 5 days. One month later, the thorax computed tomography scan revealed that the previous findings were almost completely regressed.
Med Gas Res
2022 Apr-Jun
1
8
34937995
A novel unsupervised approach based on the hidden features of Deep Denoising Autoencoders for COVID-19 disease detection
The method proposed in this paper is based on the exploitation of the compact and meaningful hidden representation provided by a Deep Denoising Convolutional Autoencoder (DDCAE) The proposed DDCAE, trained on some target CT scans in an unsupervised way, is used to build up a robust statistical representation. A suitable statistical distance measures how this target histogram is far from a companion histogram evaluated on an unknown test scan. If this distance is greater of a threshold, the test image is labeled as anomaly, i.e. the scan belongs to a patient affected by COVID-19 disease.
Expert Syst Appl
2022 Apr 15
5.89
1
9
34924632
COVID-MTL: Multitask learning with Shift3D and random-weighted loss for COVID-19 diagnosis and severity assessment
Radiology and nucleic acid test (NAT) are complementary COVID-19 diagnosis methods. CoVID-MTL learns different tasks in parallel through a novel random-weighted loss function, which assigns learning weights under Dirichlet distribution to prevent task dominance. The framework is able to accelerate convergence and improve joint learning performance compared to single-task models.
Pattern Recognit
2022 Apr
7.35
1
10
34870243
Protocol for global proteome, virome, and metaproteome profiling of respiratory specimen (VTM) in COVID-19 patient by LC-MS/MS-based analysis
In this protocol, details for identifying host, viral, or bacterial proteome (Meta-proteome) are provided. Major steps of the protocol include virus inactivation, protein quantification and digestion, desalting of peptides, high-resolution mass spectrometry (HRMS)-based analysis, and downstream bioinformatics analysis.
STAR Protoc
2022 Mar 18
1
11
34877545
Global metabolome profiling of COVID-19 respiratory specimen using high-resolution mass spectrometry (HRMS)
This protocol provides step-by-step instructions on sample collection from patients, followed by metabolite extraction. We use ultra-high-pressure liquid chromatography (UHPLC) coupled with high-resolution mass spectrometry (HRMS) for data acquisition and describe the steps for data analysis. The protocol was standardized with specific customization for SARS-CoV-2-containing respiratory specimens.
STAR Protoc
2022 Mar 18
1
12
34866721
Insights into the conformation changes of SARS-CoV-2 spike receptor-binding domain on graphene
Graphene significantly affects the secondary structure of RBD area, especially on the three key sites of binding with human ACE2, GLY476, PHE486 and ASN487. Study provides theoretical basis for the application of graphene in the protection of SARS-CoV-2.
Appl Surf Sci
2022 Mar 15
1
13
34870142
Effectiveness of infection prevention and control interventions, excluding personal protective equipment, to prevent nosocomial transmission of SARS-CoV-2: a systematic review and call for action
Many infection prevention and control (IPC) interventions have been adopted by hospitals to limit nosocomial transmission of SARS-CoV-2. The aim of this systematic review is to identify evidence on the effectiveness of these interventions. Personal protective equipment (PPE) was excluded as this intervention had been previously reviewed.
Infect Prev Pract
2022 Mar
1
14
34901582
Commercial motorcycle operators pose high risk for community transmission of coronavirus disease 2019 (COVID-19) in South-South Nigeria
WHO has given guidelines that include social distancing to prevent the spread of COVID-19, but it cannot be practiced in a commercial motorcycle operation. We examined the potentials for community transmission of SARS-CoV-2 in the South-South region of Nigeria. Prevention practices among CMOs were significantly predicted by age category, type of family, number of dependents, and place of residence.
Sci Afr
2022 Mar
1
15
34931158
Invasive fusariosis in a critically ill patient with severe COVID-19 pneumonia: A case report
Invasive fungal infections aspergillosis and candidiasis are well-documented complications in critically ill patients with acute respiratory distress syndrome due to COVID-19. However, invasive infections by other molds are rarely reported. We describe a case of invasive fusariosis in a patient with severe COVI-19 with a fatal outcome.
Med Mycol Case Rep
2022 Mar
0.702
1
16
34934633
A case report of new onset graves' disease induced by SARS-CoV-2 infection or vaccine?
The relationship that possibly exists between the COVID-19 infection, the newly developed vaccines, and thyroid disease are still under investigation. We are reporting the first case of new-onset graves' disease in a young, healthy man after being infected with the virus. It can cause systemic inflammation, which can lead to multiorgan involvement and subsequent damage.
J Clin Transl Endocrinol Case Rep
2022 Mar
1
17
34866796
COVID-19 diagnosis by SARS-CoV-2 Spike protein detection in saliva using an ultrasensitive magneto-assay based on disposable electrochemical sensor
The main technique used for diagnosing the Coronavirus disease (COVID-19) is the reverse transcription-polymerase chain reaction (RT-PCR) Technique. New magneto-assay uses magnetic beads and gold nanoparticles conjugated to human angiotensin-converting enzyme 2 (ACE2) peptide, Gln(24)-Gln(42) In terms of efficiency, the proposed technique presented a sensitivity of 100.0% and specificity of 93.7% for SARS-CoV-2 Spike protein.
Sens Actuators B Chem
2022 Feb 15
1
18
34932525
Ventilator-associated pneumonia among SARS-CoV-2 acute respiratory distress syndrome patients
16 studies reviewed ventilator-associated pneumonia (VAP) in patients undergoing mechanical ventilation because of acute respiratory distress syndrome secondary to SARS-CoV-2 infection. Most episodes of VAP were associated with Gram-negative bacteria. Potential factors driving high VAP incidence rates include immunoparalysis, prolonged ventilation, exposure to immunosuppressants, understaffing, lapses in prevention processes, and overdiagnosis.
Curr Opin Crit Care
2022 Feb 1
2.51
1
19
34539223
Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules
The ongoing outbreak of coronavirus disease 2019 (COVID-19) has highlighted that new diagnosis technologies are crucial for controlling the spread of the disease. We have designed a novel strategy to fabricate covalent organic framework (COF) capsules, which can be utilized to establish a new colorimetric assay for naked-eye detection of SARS-CoV-2 RNA.
Chem Eng J
2022 Feb 1
N/A
2
20
34898818
Behavior of cough droplets emitted from Covid-19 patient in hospital isolation room with different ventilation configurations
The ventilation system in hospital isolation rooms with infectious patients plays a significant role in minimizing the spread of viruses and the risk of infection in hospital. We found that the evaporation rate of droplets is strongly dependent on the relative humidity (RH) and, at low RH, the large-sized droplets with Covid-19 virus can evaporate quickly and become small-sized aerosols to stay in air for a long time.
Build Environ
2022 Feb 1
5.2
1
21
34907979
Pathophysiology of coronavirus-19 disease acute lung injury
Review provides an update on the pathophysiology of the COVID-19 acute lung injury. More than 230 million people have tested positive for severe acute respiratory syndrome-coronavirus-2 infection globally by September 2021. The infection affects primarily the function of the respiratory system.
Curr Opin Crit Care
2022 Feb 1
2.51
1
22
34864792
Chest imaging in patients with acute respiratory failure because of coronavirus disease 2019
CT is the technique with higher sensitivity and definition for studying chest in COVID-19 patients. LUS or bedside CXR are critical in patients requiring close and repeated monitoring. PET/CT and MRI, especially in ARDS patients, are not usually used for diagnostic or follow-up purposes.
Curr Opin Crit Care
2022 Feb 1
2.51
1
23
34722158
MicroRNAs based regulation of cytokine regulating immune expressed genes and their transcription factors in COVID-19
Coronavirus disease 2019 is characterized by the elevation of a broad spectrum of inflammatory mediators associated with poor disease outcomes. We aimed at an in-silico analysis of regulatory microRNA and their transcription factors for these inflammatory genes that may help to devise potential therapeutic strategies in the future.
Meta Gene
2022 Feb
0.88
1
24
34745319
ENResNet: A novel residual neural network for chest X-ray enhancement based COVID-19 detection
It is very difficult to detect the virus infected chest X-ray (CXR) image during early stages due to constant gene mutation of the virus. The suggested ENResNet achieves a classification accuracy 99.7% and 98.4% for binary classification and multi-class detection respectively in comparison with state-of-the-art methods.
Biomed Signal Process Control
2022 Feb
3.83
1
25
34545259
How health anxiety affected obsessive-compulsive symptoms during the COVID-19 pandemic in China: The mediation of difficulties in emotion regulation and the moderation of pathological personality traits
Health anxiety was/is a common negative emotional problem during the COVID-19 pandemic. According to the cognitive model of HA, individuals with HA continued to adopt a series of maladaptive and repetitive behaviors which were associated with obsessive-compulsive symptoms (OCS) We distributed an online survey from February 1 to February 17 in 2020 (N=1546, with average age of 25.8, and 32.7% of males) from 219 cities in China. Results showed that only four dimensions of the DER scale mediated in the predictive path of HA on OCS.
Pers Individ Dif
2022 Feb
n/a
1