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A model anti-pandemic portal for scientists & public
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Last updated: 2022 Jan 4
Total hit(s): 3304
Symptoms at disease onset predict prognosis in COVID-19 disease
The main clinical manifestations of coronavirus disease 2019 (COVID-19) onset are respiratory symptoms, including cough, sputum, and dyspnea. However, a significant proportion of patients initially manifested non-respiratory symptoms, such as fever, myalgia, and diarrhea. Respiratory patients had more secondary bacterial infections, needed the intensive care unit more (9.7% vs 2.2%, P =0.005), developed ARDS more (11.4%) and needed longer time to recover (18.5 vs 16.7 days)
Libyan J Med
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be altered.
Emerg Microbes Infect
Age and clinical signs as predictors of COVID-19 symptoms and cycle threshold value
Many COVID-19 infected people remain asymptomatic, and hence diagnosis at first presentation remains a challenge. Assessment at a presentation in primary care settings is usually done by visual triaging and basic clinical examination. This retrospective study involved investigating the medical e-records of patients who presented to a centre in Qatar for July 2020.
Libyan J Med
Hesitancy towards Covid-19 vaccination among the healthcare workers in Iraqi Kurdistan
An anonymous questionnaire on the willingness of receiving Covid-19 vaccination was submitted to a sample of HWCs in the Dohuk Governorate, Iraqi Kurdistan Region. Overall, 1704 questionnaires were analysed by means of univariate and multivariate statistics. The study included 978 males and 726 females (Mean age: 36.910.1), working in Primary Health Centres (65.8%) or in Public Hospitals (34.2%) Professions ranged from being physician/paramedics (39.3%) to administrative/laboratory staff (31.7%) Midwifes (61.1%) and assistant nurses (45.5%) were the most hesitant.
Public Health Pract (Oxf)
Invasive fusariosis in a critically ill patient with severe COVID-19 pneumonia: A case report
Invasive fungal infections aspergillosis and candidiasis are well-documented complications in critically ill patients with acute respiratory distress syndrome due to COVID-19. However, invasive infections by other molds are rarely reported. We describe a case of invasive fusariosis in a patient with severe COVI-19 with a fatal outcome.
Med Mycol Case Rep
A case report of new onset graves' disease induced by SARS-CoV-2 infection or vaccine?
The relationship that possibly exists between the COVID-19 infection, the newly developed vaccines, and thyroid disease are still under investigation. We are reporting the first case of new-onset graves' disease in a young, healthy man after being infected with the virus. It can cause systemic inflammation, which can lead to multiorgan involvement and subsequent damage.
J Clin Transl Endocrinol Case Rep
Ventilator-associated pneumonia among SARS-CoV-2 acute respiratory distress syndrome patients
16 studies reviewed ventilator-associated pneumonia (VAP) in patients undergoing mechanical ventilation because of acute respiratory distress syndrome secondary to SARS-CoV-2 infection. Most episodes of VAP were associated with Gram-negative bacteria. Potential factors driving high VAP incidence rates include immunoparalysis, prolonged ventilation, exposure to immunosuppressants, understaffing, lapses in prevention processes, and overdiagnosis.
Curr Opin Crit Care
2022 Feb 1
Towards an efficient collection and transport of COVID-19 diagnostic specimens using genetic-based algorithms
The Tunisian ministry of health established a protocol planning the sample collection from the patients at their location. A triage score is first assigned to each patient according to the symptoms he is showing, and his health conditions. Then, given the limited number of the available ambulances in each area, the location of the patients and the capacity of the nearby hospitals for receiving the samples, an ambulance scheduling and routing plan needs to be established so that specimens can be transferred to hospitals in short time.
Appl Soft Comput
Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)
The pathophysiology of coronavirus disease2019 (COVID19) is mainly dependent on the underlying mechanisms that mediate the entry of severe acute respiratory syndrome coronav virus2(SARSCoV2) into the host cells. Recent studies have indicated a higher order of complexity of the mechanisms of infectivity, given that there is a widerepertoire of possible cell entry mediators that appear to colocalise in a cell and tissuespecific manner. An insilico analysis revealed 160 candidate miRNAs with potential strong binding capacity in the aforementioned genes.
Int J Mol Med
Acute Pancreatitis in COVID-19-associated Multisystem Inflammatory Syndrome of Children-A Single Center Experience
A multisystem inflammatory syndrome in children (MIS-C) was identified as an entity temporally associated with the present COVID-19 pandemic. This inflammatory syndrome affects various organ systems including the gastrointestinal and hepatobiliary systems. Pancreatitis may be considered to be one of the parameters in the diagnostic criteria of MIS-C.
Factors Influencing University Students' Acceptance to Undertake the COVID-19 Vaccine in Jordan
This article reports findings regarding factors that influence university students' decision of acceptability to the COVID-19 vaccine in Jordan. Results highlight the continued need for clear and consistent information about the vaccine by health care decision-makers and university administrations. The study was conducted at Al Balqa' Applied University, Salt, Jordan (Dr Al Hadid) and Clinical Department, Faculty of Nursing, Al-Zaytoonah University of Jordan, Amman, Jordan.
Crit Care Nurs Q
2022 Jan-Mar 01
Challenges in the management of paediatric surgical patients in the midst of COVID-19 crisis: Our experience
COVID-19 caused by severe acute respiratory syndrome coronavirus (SARS CoV-2) has spread to more than 220 countries around the world and has almost stopped all routine surgical work. In children, the delay in the management of surgical diseases could result in significant morbidity and mortality.
Afr J Paediatr Surg
Automated COVID-19 detection from X-ray and CT images with stacked ensemble convolutional neural network
The proposed stacked CNN model achieves a sensitivity of 97.62% for the multi-class classification of X-ray images into COVID-19, Normal and Pneumonia Classes. The proposed approach shows superiority over the existing methods for the detection of the cases from the radiological images.
Biocybern Biomed Eng
Implementation of an Emergency Department-Embedded Infusion Center for the Administration of Monoclonal Antibody Therapy in Patients With Early COVID-19 Infection
This type of therapy would normally be offered at an outpatient infusion center. These centers often serve persons who are immunocompromised, and introducing COVID-19-positive individuals could threaten the safety of this population. This article describes the deployment of an emergency department-embedded infusion center set up for the purpose of supporting community members and providers electing for this treatment option.
J Infus Nurs
2022 Jan-Feb 01
Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT)
Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disease caused by SARS-CoV-2. One rare vaccine-associated event can cause fatal consequences due to development of antibodies against platelet factor 4 (PF4), which trigger platelet activation, aggregation, and possible resultant thrombosis. Expert groups have formulated guidelines for diagnosis and/or management of VITT.
Clin Chem Lab Med
2022 Jan 26
SARS-CoV-2 nucleocapsid protein binds host mRNAs and attenuates stress granules to impair host stress response
N protein rewires the G3BP1 mRNA-binding profile and suppresses the physiological stress response of host cells, which may explain the imbalanced immune response observed in SARS-CoV-2 infected patients. We found that N binds directly to host mRNAs in cells, with a preference for 3' UTRs, and modulates target mRNA stability.
2022 Jan 21
Original Research: Nurses' Experiences of Caring for Patients and Families During the COVID-19 Pandemic: Communication Challenges
The COVID-19 global pandemic has affected the delivery of health care to patients and their families. Many aspects altered because of need for social distancing, social isolation, and visitation restriction policies. As frontline caregivers, nurses have felt strongly the impact of these challenges. Findings underscore the importance of nurses' communication with patients and families under the pandemic's restricted conditions.
Am J Nurs
2022 Jan 1
Aptamer/antibody sandwich method for digital detection of SARS-CoV2 nucleocapsid protein
N protein (N protein) is the most abundant protein in SARS-CoV2 and is highly conserved. There are no homologous proteins in the human body, making it an ideal biomarker for the early diagnosis of SARS CoV2. In this manuscript, a microfluidic chip with femtoliter-sized wells was fabricated for the sensitive digital detection of N protein. The detection limit of this digital method for N protein was 33.28 p/mL, which was 300 times lower than traditional double-antibody sandwich based enzyme-linked immunosorbent assay (ELISA)
2022 Jan 1
A strategy combining 3D-DNA Walker and CRISPR-Cas12a trans-cleavage activity applied to MXene based electrochemiluminescent sensor for SARS-CoV-2 RdRp gene detection
Early diagnosis and timely management of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are the keys to preventing the spread of the epidemic and controlling new infection clues. We first activated the cleavage activity of CRISPR-Cas12a by amplifying the target DNA into a segment of double-stranded DNA through the amplification effect of a 3D DNA walker. At the same time, we designed an MXene based ECL material: PEI-Ru@Ti(3)C(2)@AuNPs, and constructed an ECL biosensor to detect the RdRp gene with a detection limit of 12.8 aM.
2022 Jan 1
A Unified Hierarchical XGBoost model for classifying priorities for COVID-19 vaccination campaign
The current ML approaches do not fully focus to answer a still unresolved and topical challenge, namely the prediction of priorities of COVID-19 vaccine administration. We measured the effectiveness of the proposed methodology for classifying all the priority classes while demonstrating a significant improvement with respect to the state of the art.
Pareto optimization of deep networks for COVID-19 diagnosis from chest X-rays
The year 2020 was characterized by the COVID-19 pandemic that has caused, by the end of March 2021, more than 2.5 million deaths worldwide. Since the beginning, besides the laboratory test, used as the gold standard, many applications have been applying deep learning algorithms to chest X-ray images to recognize patients. A wide set of experiments on several publicly available datasets, accounting for more than 92,000 images, shows that the proposed approach provides average recognition rates up to 93.54% when tested on external datasets.
Intracranial hemorrhage in a patient with severe COVID-19 acute respiratory distress syndrome on Veno-venous extra corporeal membrane oxygenation: A case report
COVID-19 can lead to severe acute respiratory distress syndrome (ARDS) where Veno-Venous Extra Corporeal Membrane Oxygenation (V-V ECMO) may be utilized for patients with severe respiratory failure. ICH is a rare and potentially fatal complication of V-VECMO - intracranial hemorrhage (ICH) In this case, the patient developed anisocoria and his GCS dropped to E1VTM1. The patient eventually succumbed to refractory septic shock with multi organ dysfunction syndrome.
Ann Med Surg (Lond)
Central retinal vein occlusion post-COVID-19 vaccination
Coronavirus disease 2019 (COVID-19) is known to cause thromboembolic episodes apart from acute respiratory distress syndrome. With large vaccine drives all across the world, there are a few case reports on post-vaccine thrombotic events seen with the AZD1222, ChAdO 1 vaccine.
Indian J Ophthalmol
Risk Factors Associated With an Impaired Antibody Response in Kidney Transplant Recipients Following 2 Doses of the SARS-CoV-2 mRNA Vaccine
The low antibody response in kidney transplant recipients may be associated with the immunosuppressive state. An age 68 years and a longer time from transplant were factors associated with antibody response. More data are needed to evaluate if KTRs may require higher vaccine doses or an additional booster dose to increase their ability to mount an immune response to the SARS-CoV-2 vaccine.
Clinical Management of COVID-19 Patients - An Update
SARS-CoV-2 virus may cause COVID-19 disease, which causes mild-to-moderate disease in 80% of laboratory-confirmed cases. A considerable age-dependent mortality is seen among elderly and other at-risk populations but among young and healthy individuals it is < 0.5%.
Semin Nucl Med