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Last updated: 2022 Jan 4
Total hit(s): 7594
The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron
The emergence of Omicron/BA.1 has brought new challenges to fight against SARS-CoV-2. A large number of mutations in the Spike protein suggest that its susceptibility to immune protection elicited by the existing COVID-19 infection and vaccines may be altered.
Emerg Microbes Infect
Symptoms at disease onset predict prognosis in COVID-19 disease
The main clinical manifestations of coronavirus disease 2019 (COVID-19) onset are respiratory symptoms, including cough, sputum, and dyspnea. However, a significant proportion of patients initially manifested non-respiratory symptoms, such as fever, myalgia, and diarrhea. Respiratory patients had more secondary bacterial infections, needed the intensive care unit more (9.7% vs 2.2%, P =0.005), developed ARDS more (11.4%) and needed longer time to recover (18.5 vs 16.7 days)
Libyan J Med
Striking lineage diversity of severe acute respiratory syndrome coronavirus 2 from non-human sources
From a set of 3595 publicly available SARS-CoV-2 genome sequences, 128 lineages were identified. Environment, Neovison vison, Odocoileus virginianus and Felis catus were the non-human sources with the highest number of lineages. Phylogenomic analyses showed viral clusters from environmental sources, including those from bats and pangolins.
Incidence Evaluation of SARS-CoV-2 Variants in the Ulsan Area, Korea, Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit: A Pilot Study
Department of Laboratory Medicine, University of Ulsan College of Medicine, is a Korean hospital. It was founded in the 1950s and has been used as a research institution for more than 30 years. The lab results have been published on numerous occasions by South Korea's leading scientists.
Ann Lab Med
2022 May 1
Effects of Iranian Polyherbal Syrup (Zufa syrup) on oxygen saturation and clinical symptoms in suspected patients with COVID-19: a triple-blinded, randomized, placebo-controlled trial
Coronavirus disease 2019 (COVID-19) pandemic has caused an urgent need for investigating potential treatments. Traditional medicine offers many potential remedies that have been historically used and have the advantage of bypassing the cultural obstacles in the practice of medicine. We aimed to investigate the efficacy of Zufa syrup in the treatment of suspected patients with mild to moderate symptoms of COVE-19.
Med Gas Res
Prediction of diagnosis and prognosis of COVID-19 disease by blood gas parameters using decision trees machine learning model: a retrospective observational study
Machine learning models can accurately assess hidden patterns among risk factors by analyzing large-datasets to quickly predict diagnosis, prognosis and mortality of diseases. This study was carried out on a total of 686 patients with COVID-19 (n = 343) and non-COVI-19 treated at Erzincan-Mengcek-Gazi-Training and Research-Hospital between April 1, 2020 and March 1, 2021. The findings in the study may aid in the early-diagnosis of the disease and the intensive-care treatment of patients who are severe.
Med Gas Res
COVID-MTL: Multitask learning with Shift3D and random-weighted loss for COVID-19 diagnosis and severity assessment
Radiology and nucleic acid test (NAT) are complementary COVID-19 diagnosis methods. CoVID-MTL learns different tasks in parallel through a novel random-weighted loss function, which assigns learning weights under Dirichlet distribution to prevent task dominance. The framework is able to accelerate convergence and improve joint learning performance compared to single-task models.
A biological sub-sequences detection using integrated BA-PSO based on infection propagation mechanism: Case study COVID-19
The longest common consecutive subsequences (LCCS) play a vital role in revealing the biological relationships between DNA/RNA sequences especially the newly discovered ones such as COVID-19. FLAT is a Fragmented local aligner technique which is an accelerated version of the local pairwise sequence alignment algorithm based on meta-heuristic algorithms. This paper introduces a modified version of FLAT based on improving the performance of the BA algorithm by integration with particle swarm optimization (PSO) algorithm. It has a preponderance to find the LCCS with the highest percentage (88%) which is better than other state-of-the-art methods.
Expert Syst Appl
2022 Mar 1
Strategies to minimize inequity in COVID-19 vaccine access in the US: Implications for future vaccine rollouts
College of Pharmacy, University of Utah, Salt Lake City, Utah, U.S., is a college of pharmacy science. The author has published more than 1,000 books on pharmacology and other topics. Her book will be published at the University's Pharmacy Library.
Lancet Reg Health Am
Vaccine efficacy and SARS-CoV-2 control in California and U.S. during the session 2020-2026: A modeling study
A mathematical model study has been done on the importance of vaccination and vaccine efficiency rate during an ongoing pandemic. The more effective a vaccine is, the less people suffer from this malign infection. According to this study, the unconfirmed-infectious and infected cases will be under control at the end of 2027 and at the mid of 2028, respectively.
Infect Dis Model
Effectiveness of infection prevention and control interventions, excluding personal protective equipment, to prevent nosocomial transmission of SARS-CoV-2: a systematic review and call for action
Many infection prevention and control (IPC) interventions have been adopted by hospitals to limit nosocomial transmission of SARS-CoV-2. The aim of this systematic review is to identify evidence on the effectiveness of these interventions. Personal protective equipment (PPE) was excluded as this intervention had been previously reviewed.
Infect Prev Pract
Commercial motorcycle operators pose high risk for community transmission of coronavirus disease 2019 (COVID-19) in South-South Nigeria
WHO has given guidelines that include social distancing to prevent the spread of COVID-19, but it cannot be practiced in a commercial motorcycle operation. We examined the potentials for community transmission of SARS-CoV-2 in the South-South region of Nigeria. Prevention practices among CMOs were significantly predicted by age category, type of family, number of dependents, and place of residence.
Big data directed acyclic graph model for real-time COVID-19 twitter stream detection
" The aim of this work is to detect anomalous events associated with COVID-19 from Twitter. We obtained the three most commonly listed terms on Twitter: ""covid"", ""death"", and ""Trump"" (21,566, 11,779, and 4761 occurrences) On 18 August 2020, our model detected the highest anomaly since many tweets mentioned the casualties' updates and debates on the pandemic that day. These terms were located near each other on vector space so that they were clustered, indicating people's most concerned topics on Twitter."
COVID-19 diagnosis by SARS-CoV-2 Spike protein detection in saliva using an ultrasensitive magneto-assay based on disposable electrochemical sensor
The main technique used for diagnosing the Coronavirus disease (COVID-19) is the reverse transcription-polymerase chain reaction (RT-PCR) Technique. New magneto-assay uses magnetic beads and gold nanoparticles conjugated to human angiotensin-converting enzyme 2 (ACE2) peptide, Gln(24)-Gln(42) In terms of efficiency, the proposed technique presented a sensitivity of 100.0% and specificity of 93.7% for SARS-CoV-2 Spike protein.
Sens Actuators B Chem
2022 Feb 15
Electrochemical sensors for the detection of SARS-CoV-2 virus
The presently used methods include rapid antigen tests, serological surveys, reverse transcription-polymerase chain reaction (RT-PCR), artificial intelligence-based techniques, and assays based on sensors/biosensors. Recently, electrochemical sensors have been developed for rapid monitoring and detection of SARS-CoV-2 from the patient's biological fluid samples.
Chem Eng J
2022 Feb 15
Molecularly imprinted polymer based electrochemical sensor for quantitative detection of SARS-CoV-2 spike protein
An electrochemical sensor based on a molecularly imprinted polymer synthetic receptor for the quantitative detection of SARS-CoV-2 spike protein subunit S1. The sensor displays a satisfactory performance with a reaction time of 15min and is capable of detecting ncovS1 both in phosphate buffered saline and patient's nasopharyngeal samples with LOD values of 15 fM and 64 fM.
Sens Actuators B Chem
2022 Feb 15
Behavior of cough droplets emitted from Covid-19 patient in hospital isolation room with different ventilation configurations
The ventilation system in hospital isolation rooms with infectious patients plays a significant role in minimizing the spread of viruses and the risk of infection in hospital. We found that the evaporation rate of droplets is strongly dependent on the relative humidity (RH) and, at low RH, the large-sized droplets with Covid-19 virus can evaporate quickly and become small-sized aerosols to stay in air for a long time.
2022 Feb 1
Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules
The ongoing outbreak of coronavirus disease 2019 (COVID-19) has highlighted that new diagnosis technologies are crucial for controlling the spread of the disease. We have designed a novel strategy to fabricate covalent organic framework (COF) capsules, which can be utilized to establish a new colorimetric assay for naked-eye detection of SARS-CoV-2 RNA.
Chem Eng J
2022 Feb 1
Towards an efficient collection and transport of COVID-19 diagnostic specimens using genetic-based algorithms
The Tunisian ministry of health established a protocol planning the sample collection from the patients at their location. A triage score is first assigned to each patient according to the symptoms he is showing, and his health conditions. Then, given the limited number of the available ambulances in each area, the location of the patients and the capacity of the nearby hospitals for receiving the samples, an ambulance scheduling and routing plan needs to be established so that specimens can be transferred to hospitals in short time.
Appl Soft Comput
The behavioral immune system and vaccination intentions during the coronavirus pandemic
The behavioral immune system is considered to be a psychological adaptation that decreases the risk of infection. Research suggests that, in the current environment, this system can produce attitudes with negative health consequences. Those with higher germ aversion during the pandemic perceived vaccines to be safer and had higher intentions to accept vaccination.
Pers Individ Dif
Linking the behavioral immune system to COVID-19 vaccination intention: The mediating role of the need for cognitive closure and vaccine hesitancy
Study finds that perceived vulnerability to disease (PVD) is associated with vaccination intentions through the need for cognitive closure (NCC) and vaccine hesitancy. Perceived infectability, on the other hand, is directly related to vaccination intention. We discuss the potential benefits of considering the roles of BIS and NCC in campaigns and policies aimed at increasing COVID-19 vaccine uptake.
Pers Individ Dif
Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate
SARS-CoV-2 protein subunit vaccines are currently being evaluated by multiple manufacturers to address the global vaccine equity gap, and need for low-cost, easy to scale, safe, and effective COVID-19 vaccines. In this paper, we report on the generation of the RBD203-N1 yeast expression construct, which produces a recombinant protein capable of eliciting a robust immune response and protection in mice against infections.
Protein Expr Purif
Monitoring populations at increased risk for SARS-CoV-2 infection in the community using population-level demographic and behavioural surveillance
Real-time population screening and identification of groups in whom positivity is highest could help monitor spread and inform public health messaging and strategy. Of 4,091,537 RT-PCR results from 482,677 individuals, 29,903 (073%) were positive. As positivity rose September-November 2020, rates were independently higher in Northern England, major urban conurbations, more deprived areas, and larger households. Rates were also higher in those returning from abroad, and working in healthcare or outside of home.
Lancet Reg Health Eur
Computational screening and biochemical analysis of Pistacia integerrima and Pandanus odorifer plants to find effective inhibitors against Receptor-Binding domain (RBD) of the spike protein of SARS-Cov-2
The mortality rate from COVID-19 remains high due to the fourth or fifth wave and the delta variant of the coronavirus. An effective mechanistic investigation in treating this disease is urgently needed. Three phytochemicals, 28-demethyl-beta-amyrone, 24-Noroleana-3,12-diene, and stigmasterol, displayed binding free energy values of-8.3, -7.5 Kcal/mol, respectively, in complexes with the spike protein of SARS-CoV-2.
Arab J Chem
Fire association with respiratory disease and COVID-19 complications in the State of Pará, Brazil
Brazil has faced two simultaneous problems related to respiratory health: forest fires and the high mortality rate due to COVID-19 pandemics. Amazon rain forest is one of the Brazilian biomes that suffers the most with fires caused by droughts and illegal deforestation. These fires can bring respiratory diseases associated with air pollution, and the State of Par in Brazil is the most affected.
Lancet Reg Health Am