Viral protein-Other antibody complex

Macro molecule
Gene
Interacting molecule/ protein
Interacting gene
PDB ID
Title
Structure Title
Experimental Method
Resolution (Å)
PubMed ID
Structure
Spike glycoprotein
S, 2
Nanobody Ty1
~
6ZXN
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)
ELECTRON MICROSCOPY
2.93
32887876
3D view
Spike glycoprotein
S, 2
Neutralising sybody (Sb23)
~
7A29
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation
ELECTRON MICROSCOPY
2.94
33149112
3D view
Spike glycoprotein
S, 2
Sybody 23
~
7A25
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23)
ELECTRON MICROSCOPY
3.06
33149112
3D view
Spike glycoprotein
S, 2
Nanobody
~
6Z43
Structural basis for a potent neutralising single-domain antibody that blocks SARS-CoV-2 binding to its receptor ACE2
Cryo-EM Structure of SARS-CoV-2 Spike : H11-D4 Nanobody Complex
ELECTRON MICROSCOPY
3.3
To be published
3D view
Replicase polyprotein 1a
rep, 1a-1b
Ubiquitin-like protein ISG15
Isg15, G1p2, Ucrp,
6YVA
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
PLpro-C111S with mISG15
X-RAY DIFFRACTION
3.18
32726803
3D view
Spike glycoprotein
S, 2
Nanobody H11-D4
~
6YZ5
H11-D4 complex with SARS-CoV-2 RBD
H11-D4 complex with SARS-CoV-2 RBD
X-RAY DIFFRACTION
1.8
To be published
3D view
Spike glycoprotein,Fibritin
S,2, wac
Nanobody H11-H4
~
6ZHD
H11-H4 bound to Spike
H11-H4 bound to Spike
ELECTRON MICROSCOPY
3.7, 3.7
To be published
3D view
Spike glycoprotein
S,2
Synthetic nanobody SR4
~
7C8V
Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
Structure of sybody SR4 in complex with the SARS-CoV-2 S Receptor Binding domain (RBD)
X-RAY DIFFRACTION
2.15
To be published
3D view
Spike glycoprotein
S,2
Synthetic nanobody MR17
~
7C8W
Rapid selection of synthetic nanobodies against the receptor binding domain of SARS-CoV-2 S protein
Structure of sybody MR17 in complex with the SARS-CoV-2 S receptor-binding domain (RBD)
X-RAY DIFFRACTION
2.77
To be published
3D view
Spike glycoprotein
S,2
sybody MR17-K99Y
~
7CAN
Potent synthetic nanobodies against SARS-CoV-2 and molecular basis for neutratlization
Structure of sybody MR17-K99Y in complex with the SARS-CoV-2 S Receptor-binding domain (RBD)
X-RAY DIFFRACTION
2.94
To be published
3D view
Spike glycoprotein
S,2
Nanobody Nb20
~
7JVB
Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2.
Crystal structure of the SARS-CoV-2 spike receptor-binding domain (RBD) with nanobody Nb20
X-RAY DIFFRACTION
3.287
33154108
3D view
Spike glycoprotein
S,2
Synthetic nanobody Nb6
~
7KKK
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6
ELECTRON MICROSCOPY
3.03
33154106
3D view
Spike glycoprotein
S,2
Synthetic nanobody mNb6
~
7KKL
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6
ELECTRON MICROSCOPY
2.85
33154106
3D view