Viral proteins complex

Macromolecule
Gene
Interacting molecule/ protein
Interacting gene
PDB ID
Title
Structure Title
Experimental Method
Resolution (Å)
PubMed ID
Structure
Replicase polyprotein 1a (A, C chains)
rep, 1a-1b
Replicase polyprotein 1a (B,D chains)
rep, 1a-1b
6YHU
Structural analysis of the putative SARS-CoV-2 primase complex.
Crystal structure of the nsp7-nsp8 complex of SARS-CoV-2
X-RAY DIFFRACTION
2
32535228
3D view
nsp7
rep, 1a-1b
nsp8
rep, 1a-1b
6XIP
The 1.5 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
The 1.5 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
X-RAY DIFFRACTION
1.5
to be published
3D view
NSP 8
rep, 1a-1b
NSP 7
rep, 1a-1b
6M5I
Crystal structure of 2019-nCoV nsp7-nsp8c complex
Crystal structure of 2019-nCoV nsp7-nsp8c complex
X-RAY DIFFRACTION
2.496
to be published
3D view
NSP 12 ( A chain )
rep, 1a-1b
NSP 7 (C chain) NSP 8 (B, D chains)
rep, 1a-1b
6M71
Structure of the RNA-dependent RNA polymerase from COVID-19 virus.
SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors
ELECTRON MICROSCOPY
2.9
32277040
3D view
Nsp16
rep, 1a-1b
Nsp10
rep, 1a-1b
7BQ7
Crystal structure of 2019-nCoV nsp16-nsp10 complex
Crystal structure of 2019-nCoV nsp16-nsp10 complex
X-RAY DIFFRACTION
2.37
To be published
3D view
Nsp16
rep, 1a-1b
Nsp10
rep, 1a-1b
7C2I
Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.
Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization)
X-RAY DIFFRACTION
2.5
32728018
3D view
RNA-directed RNA polymerase
rep, 1a-1b
Nsp 8 Nsp 7
rep, 1a-1b
7C2K
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase.
COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex
ELECTRON MICROSCOPY
2.93
32526208
3D view
Nsp12
rep, 1a-1b
Nsp8 Nsp7
rep, 1a-1b
7BV1
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
ELECTRON MICROSCOPY
2.8
32358203
3D view
Replicase polyprotein 1ab ( A, B, D )
rep, 1a-1b
Replicase polyprotein 1ab C
rep, 1a-1b
7BW4
Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2.
Structure of the RNA-dependent RNA polymerase from SARS-CoV-2
ELECTRON MICROSCOPY
3.7
32531208
3D view
Nsp7
rep, 1a-1b
Nsp8
rep, 1a-1b
7JLT
Crystal Structure of SARS-CoV-2 NSP7-NSP8 complex.
Crystal Structure of SARS-CoV-2 NSP7-NSP8 complex.
X-RAY DIFFRACTION
2.7
To be published
3D view
Nsp16
rep, 1a-1b
Nsp10
rep, 1a-1b
6W4H
1.80 Angstrom Resolution Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2
1.80 Angstrom Resolution Crystal Structure of NSP16 - NSP10 Complex from SARS-CoV-2
X-RAY DIFFRACTION
1.8
To be published
3D view
2'-O-methyltransferase
rep, 1a-1b
Nsp10
rep, 1a-1b
6W61
Crystal Structure of the methyltransferase-stimulatory factor complex of NSP16 and NSP10 from SARS CoV-2.
Crystal Structure of the methyltransferase-stimulatory factor complex of NSP16 and NSP10 from SARS CoV-2.
X-RAY DIFFRACTION
2
To be published
3D view
Nsp16
rep, 1a-1b
Nsp10
rep, 1a-1b
6W75
1.95 Angstrom Resolution Crystal Structure of NSP10 - NSP16 Complex from SARS-CoV-2
1.95 Angstrom Resolution Crystal Structure of NSP10 - NSP16 Complex from SARS-CoV-2
X-RAY DIFFRACTION
1.951
To be published
3D view
Nsp7
rep, 1a-1b
Nsp8
rep, 1a-1b
6WIQ
Crystal structure of the co-factor complex of NSP7 and the C-terminal domain of NSP8 from SARS CoV-2
Crystal structure of the co-factor complex of NSP7 and the C-terminal domain of NSP8 from SARS CoV-2
X-RAY DIFFRACTION
2.85
To be published
3D view
Nsp16
rep, 1a-1b
Nsp10
rep, 1a-1b
6WKQ
1.98 Angstrom Resolution Crystal Structure of NSP16-NSP10 Heterodimer from SARS-CoV-2 in Complex with Sinefungin.
1.98 Angstrom Resolution Crystal Structure of NSP16-NSP10 Heterodimer from SARS-CoV-2 in Complex with Sinefungin
X-RAY DIFFRACTION
1.98
To be published
3D view
Nsp7
rep, 1a-1b
Nsp8
rep, 1a-1b
6WQD
The 1.95 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
The 1.95 A Crystal Structure of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS-CoV-2
X-RAY DIFFRACTION
1.95
To be published
3D view
Nsp7
rep, 1a-1b
Nsp8
rep, 1a-1b
6WTC
Crystal Structure of the Second Form of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
Crystal Structure of the Second Form of the Co-factor Complex of NSP7 and the C-terminal Domain of NSP8 from SARS CoV-2
X-RAY DIFFRACTION
1.85
To be published
3D view