Complete Proteins

Protein Name
Gene
PDB ID
Title
Structure Title
Method
Resoultion (Å)
PubMed ID
Structure
Helicase NSP13
rep, 1a-1b
6ZSL
Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
Crystal structure of the SARS-CoV-2 helicase at 1.94 Angstrom resolution
X-ray diffraction
1.94
To be published
3D view
Spike glycoprotein
S,2
6ZWV
Structures and distributions of SARS-CoV-2 spike proteins on intact virions.
Cryo-EM structure of SARS-CoV-2 Spike Proteins on intact virions: 3 Closed RBDs
ELECTRON MICROSCOPY
3.50
32805734
3D view
Spike glycoprotein,Fibritin
S,2
7A4N
Stabilizing the Closed SARS-CoV-2 Spike Trimer
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer)
Electron Microscopy
2.75
Biorxiv
3D view
Spike glycoprotein
S,2
7A93
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion.
SARS-CoV-2 Spike Glycoprotein with 2 RBDs Erect
Electron Microscopy
5.90
32942285
3D view
Spike glycoprotein
S,2
7AD1
Stabilizing the Closed SARS-CoV-2 Spike Trimer
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(One up trimer)
Electron Microscopy
2.92
Biorxiv
3D view
Main Protease (Mpro)
rep, 1a-1b
7AF0
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Structure of SARS-CoV-2 Main Protease bound to Ipidacrine.
X-ray diffraction
1.70
Biorxiv
3D view
Spike glycoprotein,Fibritin (Chimeric protein)
S,2
6Z97
Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Structure of the prefusion SARS-CoV-2 spike glycoprotein
Electron Microscopy
3.40
32585135
3D view
Main Protease (3CLpro/Mpro)
rep, 1a-1b
7ALI
Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup P2(1)).
Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup P2(1)).
Electron Microscopy
1.65
To be published
3D view
Main Protease (3CLpro/Mpro)
rep, 1a-1b
7ALH
Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup C2).
Crystal structure of the main protease (3CLpro/Mpro) of SARS-CoV-2 at 1.65A resolution (spacegroup C2).
X-ray diffraction
1.65
To be published
3D view
Spike glycoprotein
S,2
6ZB5
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
SARS CoV-2 Spike protein, Closed conformation, C3 symmetry
Electron Microscopy
2.85
32958580
3D view
Spike glycoprotein
S,2
6ZB4
Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein.
SARS CoV-2 Spike protein, Closed conformation, C1 symmetry
Electron Microscopy
3.03
32958580
3D view
Spike glycoprotein
S,2
6ZGE
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Uncleavable Spike Protein of SARS-CoV-2 in Closed Conformation
Electron Microscopy
2.60
32647346
3D view
Spike glycoprotein
S,2
6ZGG
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Furin Cleaved Spike Protein of SARS-CoV-2 with One RBD Erect
Electron Microscopy
3.80
32647346
3D view
Spike glycoprotein
S,2
6ZGI
SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects.
Furin Cleaved Spike Protein of SARS-CoV-2 in Closed Conformation
Electron Microscopy
2.90
32647346
3D view
Replicase polyprotein 1ab
rep, 1a-1b
6ZPE
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.
Nonstructural protein 10 (nsp10) from SARS CoV-2
X-ray diffraction
1.58
33036230
3D view
Spike glycoprotein
S,2
6ZP5
Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
SARS-CoV-2 spike in prefusion state (flexibility analysis, 1-up closed conformation)
Electron Microscopy
3.10
32676604
3D view
nsp10
rep, 1a-1b
6ZCT
Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2.
Nonstructural protein 10 (nsp10) from SARS CoV-2
X-ray diffraction
2.55
33036230
3D view
SARS coronavirus 2 main proteinase
rep, 1a-1b
7AR5
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Structure of apo SARS-CoV-2 Main Protease with small beta angle, space group C2.
X-ray diffraction
1.40
Biorxiv
3D view
Main Protease
rep, 1a-1b
7AR6
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding
Structure of apo SARS-CoV-2 Main Protease with large beta angle, space group C2.
X-ray diffraction
1.40
Biorxiv
3D view
Spike glycoprotein
S,2
6ZP7
Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
SARS-CoV-2 spike in prefusion state (flexibility analysis, 1-up open conformation)
Electron Microscopy
3.30
32676604
3D view
Spike glycoprotein
S,2
6ZOX
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x2 disulphide-bond mutant, G413C, V987C, single Arg S1/S2 cleavage site)
Electron Microscopy
3.00
32737467
3D view
Spike glycoprotein
S,2
6ZOW
Continuous flexibility analysis of SARS-CoV-2 Spike prefusion structures.
SARS-CoV-2 spike in prefusion state
Electron Microscopy
3.00
32676604
3D view
Spike glycoprotein
S,2
6ZOZ
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Locked State
Electron Microscopy
3.50
32737467
3D view
Spike glycoprotein
S,2
6ZOY
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State
Electron Microscopy
3.10
32737467
3D view
Spike glycoprotein
S,2
6ZP1
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Closed State
Electron Microscopy
3.30
32737467
3D view
Spike glycoprotein
S,2
6ZP0
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of SARS-CoV-2 Spike Protein Trimer (single Arg S1/S2 cleavage site) in Closed State
Electron Microscopy
3.00
32737467
3D view
Spike glycoprotein
S,2
6ZP2
A thermostable, closed SARS-CoV-2 spike protein trimer.
Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Locked State
Electron Microscopy
3.10
32737467
3D view
3C-like proteinase
rep, 1a-1b
6XOA
The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation
The crystal structure of 3CL MainPro of SARS-CoV-2 with C145S mutation
X-ray diffraction
2.10
To be published
3D view
Replicase polyprotein 1ab
rep, 1a-1b
6Y2E
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors.
Crystal structure of the free enzyme of the SARS-CoV-2 (2019-nCoV) main protease
X-ray diffraction
1.75
32198291
3D view
Spike glycoprotein
S,2
6XRA
Distinct conformational states of SARS-CoV-2 spike protein.
Distinct conformational states of SARS-CoV-2 spike protein
Electron Microscopy
3.00
32694201
3D view
Spike glycoprotein
S,2
6XR8
Distinct conformational states of SARS-CoV-2 spike protein.
Distinct conformational states of SARS-CoV-2 spike protein
Electron Microscopy
2.90
32694201
3D view
Replicase polyprotein 1ab
rep, 1a-1b
6Y84
COVID-19 main protease with unliganded active site
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19)
X-ray diffraction
1.39
To be published
3D view
Replicase polyprotein 1ab
rep, 1a-1b
6YB7
COVID-19 main protease with unliganded active site
SARS-CoV-2 main protease with unliganded active site (2019-nCoV, coronavirus disease 2019, COVID-19).
X-ray diffraction
1.25
To be published
3D view
Spike glycoprotein
S,2
6XS6
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
SARS-CoV-2 Spike D614G variant, minus RBD
Electron Microscopy
3.70
32991842
3D view
3C-like proteinase
rep, 1a-1b
6XHU
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL Mpro: Insights for enzyme mechanism and drug design
X-ray diffraction
1.80
33063790
3D view
3C-like proteinase
rep, 1a-1b
6YI3
The crystal structure of 3CL MainPro of SARS-CoV-2 with oxidized Cys145 (Sulfenic acid cysteine).
The crystal structure of 3CL MainPro of SARS-CoV-2 with oxidized Cys145 (Sulfenic acid cysteine).
Solution NMR
~
To be published
3D view
3C-like proteinase
rep, 1a-1b
6XKH
The 1.28A crystal structure of 3CL-MainPro of SARS-CoV-2 with oxidised C145 (sulfinic acid cysteine)
The 1.28A crystal structure of 3CL-MainPro of SARS-CoV-2 with oxidised C145 (sulfinic acid cysteine)
X-ray diffraction
1.28
To be published
3D view
Spike glycoprotein
S,2
6XKL
Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
SARS-CoV-2 HexaPro S One RBD up
Electron Microscopy
3.21
32703906
3D view
Spike glycoprotein
S,2
6XLU
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 4.0
Electron Microscopy
2.40
32637958
3D view
Spike glycoprotein
S,2
6XM5
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 5.5, all RBDs down
Electron Microscopy
3.10
32637958
3D view
Spike glycoprotein
S,2
6XM0
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Consensus structure of SARS-CoV-2 spike at pH 5.5
Electron Microscopy
2.70
32637958
3D view
Main protease
rep, 1a-1b
6M03
The crystal structure of COVID-19 main protease in apo form
The crystal structure of COVID-19 main protease in apo form
X-ray diffraction
2.00
To be published
3D view
Spike glycoprotein
S,2
6M1V
Crystal structure of post fusion core of 2019-nCoV S2 subunit
Crystal structure of post fusion core of 2019-nCoV S2 subunit
X-ray diffraction
1.50
To be published
3D view
SARS-CoV-2 3CL protease
rep, 1a-1b
6M2Q
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.
SARS-CoV-2 3CL protease (3CL pro) apo structure (space group C21)
X-ray diffraction
1.70
32737471
3D view
Replicase polyprotein 1ab
rep, 1a-1b
7JR4
SARS-CoV-2 3CL protease with alternative conformation of the active site promoted by methylene-bridged cysteine and lysine residues
SARS-CoV-2 3CL protease with alternative conformation of the active site promoted by methylene-bridged cysteine and lysine residues
X-ray diffraction
1.55
To be published
3D view
Spike glycoprotein
S,2
7DF3
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
SARS-CoV-2 S trimer, S-closed
Electron Microscopy
2.70
33277323
3D view
3C-like proteinase
rep, 1a-1b
7CWC
Ambient Temperature Serial Femtosecond X-ray Crystallography Reveals Altered Conformation of SARS-CoV-2 Main Protease Active Site for improved drug repurposing studies
Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 2.1 A Resolution (P212121)
X-ray diffraction
2.10
To be published
3D view
3C-like proteinase
rep, 1a-1b
7CWB
Ambient Temperature Serial Femtosecond X-ray Crystallography Reveals Altered Conformation of SARS-CoV-2 Main Protease Active Site for improved drug repurposing studies
Ambient-Temperature Serial Femtosecond X-ray Crystal structure of SARS-CoV-2 Main Protease at 1.9 A Resolution (C121)
X-ray diffraction
1.90
To be published
3D view
Papain-like protease (PLPro)
7D6H
Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
X-ray diffraction
1.60
To be published
3D view
Replicase polyprotein 1ab
rep, 1a-1b
7CJD
Crystal structure of SARS-CoV-2 papain-like protease.
Crystal structure of the SARS-CoV-2 PLpro C111S mutant
X-ray diffraction
2.50
32895623
3D view
Spike glycoprotein
S,2
7CAB
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
Electron Microscopy
3.52
32703908
3D view
3C-like proteinase
rep, 1a-1b
7BRO
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Crystal structure of the 2019-nCoV main protease
X-ray diffraction
2.00
32887884
3D view
3C-like proteinase
rep, 1a-1b
7C2Y
COVID-2019 main protease in the apo state
The crystal structure of COVID-2019 main protease in the apo state
X-ray diffraction
1.91
To be published
3D view
3C-like proteinase
rep, 1a-1b
7C2Q
The crystal structure of COVID-19 main protease in the apo state
The crystal structure of COVID-19 main protease in the apo state
X-ray diffraction
1.93
To be published
3D view
Spike glycoprotein
S,2
7DK3
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.
SARS-CoV-2 S trimer, S-open
Electron Microscopy
6.00
33277323
3D view
3C-like proteinase
rep, 1a-1b
7K3T
Hepatitis C Virus NSP3/NSP4A Inhibitors as Promising Lead Compounds for the Design of New Covalent Inhibitors for SARS-CoV-2 3CLpro/Mpro Protease
Crystal Structure of SARS-CoV-2 Main Protease (3CLpro/Mpro) in the Apo Form at 1.2 A Resolution
X-ray diffraction
1.20
To be published
3D view
Spike glycoprotein
S,2
7KDJ
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer fully cleaved by furin without the P986-P987 stabilizing mutations (S-RRAR-D614G)
Electron Microscopy
3.49
33052347
3D view
Spike glycoprotein
S,2
7KDK
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G)
Electron Microscopy
2.80
33052347
3D view
Spike glycoprotein
S,2
7KDH
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 RBD up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS)
Electron Microscopy
3.33
33052347
3D view
Spike glycoprotein
S,2
7KDI
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer fully cleaved by furin without the P986-P987 stabilizing mutations (S-RRAR-D614G)
Electron Microscopy
3.26
33052347
3D view
Spike glycoprotein
S,2
7KDL
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1-RBD up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G)
Electron Microscopy
2.96
33052347
3D view
Spike glycoprotein
S,2
7KDG
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS)
Electron Microscopy
3.01
33052347
3D view
Spike glycoprotein
S,2
7KEC
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G Sub-Classification)
Electron Microscopy
3.84
33052347
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
7K9P
Room temperature structure of NendoU (Uridylate-specific endoribonuclease, Nsp15) solved using SFX.
Room temperature structure of NSP15 Endoribonuclease from SARS CoV-2 solved using SFX.
X-ray diffraction
2.60
To be published
3D view
Spike glycoprotein
S,2
7JWY
A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike.
Structure of SARS-CoV-2 spike at pH 4.5
Electron Microscopy
2.50
32637958
3D view
ORF8 protein
ORF 8
7JX6
Crystal Structure of the SARS-CoV-2 ORF8 Protein
Structure of the SARS-CoV-2 ORF8 encoded accessory protein
X-ray diffraction
1.61
To be published
3D view
NSP 1
rep, 1a-1b
7K7P
Structure of SARS-CoV-2 nonstuctural protein 1
Structure of SARS-CoV-2 nonstuctural protein 1
X-ray diffraction
1.77
To be published
3D view
3C-like proteinase
rep, 1a-1b
7JVZ
SARS CoV-2 main protease 3CLpro, room temperature damage free XFEL monoclinic structure
SARS CoV-2 main protease 3CLpro, room temperature damage free XFEL monoclinic structure
X-ray diffraction
2.50
To be published
3D view
3C-like proteinase
rep, 1a-1b
7JUN
Unusual zwitterionic catalytic site of SARS-CoV-2 main protease revealed by neutron crystallography.
Joint neutron/X-ray structure of SARS-CoV-2 3CL Mpro at room temperature
X-ray diffraction
2.30
33060199
3D view
NSP 8
NSP 8
7JTL
Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.
Structure of SARS-CoV-2 ORF8 accessory protein
X-ray diffraction
2.04
32869027
3D view
Host translation inhibitor nsp1
rep, 1a-1b
7K3N
Crystal Structure of NSP1 from SARS-CoV-2
Crystal Structure of NSP1 from SARS-CoV-2
X-ray diffraction
1.65
To be published
3D view
Spike glycoprotein
S,2
7JJI
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate.
Structure of SARS-CoV-2 3Q-2P full-length prefusion spike trimer (C3 symmetry)
Electron Microscopy
3.60
32793901
3D view
Spike glycoprotein
S,2
7JJJ
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate.
Structure of SARS-CoV-2 3Q-2P full-length dimers of spike trimers
Electron Microscopy
4.50
32793901
3D view
3C-like proteinase
rep, 1a-1b
7JFQ
The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
The crystal structure of 3CL MainPro of SARS-CoV-2 with de-oxidized C145
X-ray diffraction
1.55
To be published
3D view
Protein 7a
7a
6W37
Structure of the SARS-CoV-2 ORF7a encoded accessory protein
Structure of the SARS-CoV-2 ORF7a encoded accessory protein
X-ray diffraction
2.90
To be published
3D view
3C-like proteinase
rep, 1a-1b
7KYU
The crystal structure of SARS-CoV-2 Main Protease with the formation of Cys145-1H-indole-5-carboxylate
The crystal structure of SARS-CoV-2 Main Protease with the formation of Cys145-1H-indole-5-carboxylate
X-ray diffraction
1.48
To be published
3D view
Replicase polyprotein 1ab
rep, 1a-1b
7KS5
SARS-CoV-2 Main Protease in mature form
SARS-CoV-2 Main protease immature form - F2X Entry Library E03 fragment
X-ray diffraction
2.81
To be published
3D view
Main protease
rep, 1a-1b
7KW5
SARS-CoV-2 Main protease immature form - F2X Entry Library E06 fragment
SARS-CoV-2 Main protease immature form - F2X Entry Library E06 fragment
X-ray diffraction
2.23
To be published
3D view
Main protease
rep, 1a-1b
7KVR
SARS-CoV-2 Main protease immature form - FMAX Library E09 fragment
SARS-CoV-2 Main protease immature form - FMAX Library E09 fragment
X-ray diffraction
2.12
To be published
3D view
Main protease
rep, 1a-1b
7KVL
SARS-CoV-2 Main protease immature form - FMAX Library E01 fragment
SARS-CoV-2 Main protease immature form - FMAX Library E01 fragment
X-ray diffraction
2.09
To be published
3D view
3C-like proteinase
rep, 1a-1b
7KPH
SARS-CoV-2 Main Protease in mature form
SARS-CoV-2 Main Protease in mature form
X-ray diffraction
1.46
To be published
3D view
Spike glycoprotein
S,2
7KJ5
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent in vitro.
SARS-CoV-2 Spike Glycoprotein, prefusion with one RBD up conformation
Electron Microscopy
3.60
32995768
3D view
Main protease
rep, 1a-1b
7KFI
SARS-CoV-2 Main protease immature form - apo structure
SARS-CoV-2 Main protease immature form - apo structure
X-ray diffraction
1.60
To be published
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
7KF4
Crystal structure from SARS-COV2 NendoU NSP15
Crystal structure from SARS-CoV-2 NendoU NSP15
X-ray diffraction
2.61
To be published
3D view
Spike glycoprotein
S,2
7KE6
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Electron Microscopy
3.10
33052347
3D view
Spike glycoprotein
S,2
7KEA
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub classification)
Electron Microscopy
3.33
33052347
3D view
Spike glycoprotein
S,2
7KEB
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1RBD up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Electron Microscopy
3.48
33052347
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
7KEG
Crystal structure from SARS-COV2 NendoU NSP15
Crystal structure from SARS-COV2 NendoU NSP15
X-ray diffraction
2.90
To be published
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
7KEH
Crystal structure from SARS-CoV-2 NendoU NSP15
Crystal structure from SARS-CoV-2 NendoU NSP15
X-ray diffraction
2.59
To be published
3D view
Spike glycoprotein
S,2
7KE9
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 1-RBD-up Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Electron Microscopy
3.08
33052347
3D view
Spike glycoprotein
S,2
7KE4
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G Sub-class)
Electron Microscopy
3.21
33052347
3D view
Spike glycoprotein
S,2
7KE7
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3-RBD-down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G Sub-Classification)
Electron Microscopy
3.32
33052347
3D view
Spike glycoprotein
S,2
7KE8
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS-D614G sub-classification)
Electron Microscopy
3.26
33052347
3D view
Peptidase C16
rep, 1a-1b
6XG3
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, at room temperature
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, at room temperature
X-ray diffraction
2.48
To be published
3D view
Spike glycoprotein
S,2
6XF6
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD up)
Electron Microscopy
4.00
32742241
3D view
Spike glycoprotein
S,2
6XF5
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (RBDs down)
Electron Microscopy
3.45
32742241
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
6XDH
Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2
Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2
X-ray diffraction
2.35
To be published
3D view
Protein 3a
3a
6XDC
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Cryo-EM structure of SARS-CoV-2 ORF3a
Electron Microscopy
2.90
32587976
3D view
3C-like proteinase
rep, 1a-1b
6XB2
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
2.10
33063790
3D view
3C-like proteinase
rep, 1a-1b
6XB0
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
1.80
33063790
3D view
3C-like proteinase
rep, 1a-1b
6XB1
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
1.80
33063790
3D view
NSP 3
rep, 1a-1b
6WZU
The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group
The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group
X-ray diffraction
1.79
To be published
3D view
NSP 9
rep, 1a-1b
6WXD
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
SARS-CoV-2 Nsp9 RNA-replicase
X-ray diffraction
2.00
32592996
3D view
Spike glycoprotein
S,2
6X6P
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
Electron Microscopy
3.22
32587972
3D view
Spike glycoprotein
S,2
7DDN
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
SARS-Cov2 S protein at open state
Electron Microscopy
6.3
Nature Communications volume 12, Article number: 264 (2021)
3D view
Spike glycoprotein
S,2
7DDD
Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
SARS-Cov2 S protein at close state
Electron Microscopy
3
Nature Communications volume 12, Article number: 264 (2021)
3D view
3C-like proteinase
rep, 1a-1b
7JR3
SARS-CoV-2 3CL protease crystallized under reducing conditions.
SARS-CoV-2 3CL protease crystallized under reducing conditions
X-ray diffraction
1.55
To be published
3D view
Spike glycoprotein
S,2
6XM4
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2
Electron Microscopy
2.9
32637958
3D view
Spike glycoprotein
S,2
6XM3
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1
Electron Microscopy
2.9
32637958
3D view
Nsp3
rep, 1a-1b
7D47
Crystal structure of SARS-CoV-2 Papain-like protease
Crystal structure of SARS-CoV-2 Papain-like protease C111S
X-ray diffraction
1.97
To be published
3D view
Nsp9
rep, 1a-1b
6W4B
The crystal structure of Nsp9 replicase protein of COVID-19
The crystal structure of Nsp9 RNA binding protein of SARS CoV-2
X-ray diffraction
2.95
To be published
3D view
3C-like proteinase peptide, Nsp9
rep, 1a-1b
6W9Q
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase
X-ray diffraction
2.05
32592996
3D view
Nsp3
rep, 1a-1b
6VXS
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2
X-ray diffraction
2.03
32939273
3D view
Papain-like proteinase
rep, 1a-1b
6W9C
The crystal structure of papain-like protease of SARS CoV-2
The crystal structure of papain-like protease of SARS CoV-2
X-ray diffraction
2.7
To be published
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
6VWW
Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2.
X-ray diffraction
2.2
32304108
3D view
Nsp9
rep, 1a-1b
6WC1
Identification of a putative peptide-binding site at the dimer interface of the SARS-CoV-2 Nsp9 RNA-replicase.
Peptide-bound SARS-CoV-2 Nsp9 RNA-replicase
X-ray diffraction
2.4
To be published
3D view
Nsp3
rep, 1a-1b
6WEN
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes.
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in the apo form
X-ray diffraction
1.35
32939273
3D view
Spike glycoprotein
S,2
6X2A
Controlling the SARS-CoV-2 spike glycoprotein conformation.
SARS-CoV-2 u1S2q 1 Up RBD Spike Protein Trimer
Electron Microscopy
3.3
32699321
3D view
Spike glycoprotein
S,2
6X2C
Controlling the SARS-CoV-2 spike glycoprotein conformation.
SARS-CoV-2 u1S2q All Down RBD State Spike Protein Trimer
Electron Microscopy
3.2
32699321
3D view
Spike glycoprotein
S,2
6X2B
Controlling the SARS-CoV-2 spike glycoprotein conformation.
SARS-CoV-2 u1S2q 2 RBD Up Spike Protein Trimer
Electron Microscopy
3.6
32699321
3D view
Spike glycoprotein
S,2
6X29
Controlling the SARS-CoV-2 spike glycoprotein conformation.
SARS-CoV-2 rS2d Down State Spike Protein Trimer
Electron Microscopy
2.7
32699321
3D view
Nsp3
rep, 1a-1b
6WRH
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant
X-ray diffraction
1.6
To be published
3D view
3C-like proteinase
rep, 1a-1b
6WTK
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
X-ray diffraction
2
32855413
3D view
3C-like proteinase
rep, 1a-1b
6WTM
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
X-ray diffraction
1.85
32855413
3D view
3C-like proteinase
rep, 1a-1b
6WTJ
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
X-ray diffraction
1.9
32855413
3D view
Spike glycoprotein
S,2
6X6P
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis.
Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
Electron Microscopy
3.22
32587972
3D view
Spike glycoprotein
S,2
6X79
Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation.
Prefusion SARS-CoV-2 S ectodomain trimer covalently stabilized in the closed conformation
Electron Microscopy
2.9
32753755
3D view
Nsp9
rep, 1a-1b
6WXD
Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
SARS-CoV-2 Nsp9 RNA-replicase
X-ray diffraction
2
32592996
3D view
Peptidase C16
rep, 1a-1b
6XG3
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, at room temperature
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant, at room temperature
X-ray diffraction
2.48
To be published
3D view
Spike glycoprotein
S,2
6XF6
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD up)
Electron Microscopy
4
32742241
3D view
Spike glycoprotein
S,2
6XF5
Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes.
Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (RBDs down)
Electron Microscopy
3.45
32742241
3D view
Uridylate-specific endoribonuclease
rep, 1a-1b
6XDH
Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2
Crystal Structure of NendoU (Uridylate-specific endoribonuclease, nsp15) from Betacoronavirus SARS-CoV-2
X-ray diffraction
2.35
To be published
3D view
Protein 3a
3a
6XDC
Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs.
Cryo-EM structure of SARS-CoV-2 ORF3a
Electron Microscopy
2.9
32587976
3D view
Nsp3
rep, 1a-1b
6WZU
The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group
The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group
X-ray diffraction
1.79
To be published
3D view
3C-like proteinase
rep, 1a-1b
6XB1
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
1.8
33063790
3D view
3C-like proteinase
rep, 1a-1b
6XB0
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
1.8
33063790
3D view
3C-like proteinase
rep, 1a-1b
6XB2
Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M pro : insights into enzyme mechanism and drug design.
Room temperature X-ray crystallography reveals catalytic cysteine in the SARS-CoV-2 3CL Mpro is highly reactive: Insights for enzyme mechanism and drug design
X-ray diffraction
1.8
33063790
3D view
Spike glycoprotein
S,2
6XM4
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 2
Electron Microscopy
2.9
32637958
3D view
Spike glycoprotein
S,2
6XM3
Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains
Structure of SARS-CoV-2 spike at pH 5.5, single RBD up, conformation 1
Electron Microscopy
2.9
32637958
3D view
3C-like proteinase
rep, 1a-1b
7JOY
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with its C-terminal autoprocessing sequence.
X-ray diffraction
2
33208735
3D view
3C-like proteinase
rep, 1a-1b
7JP1
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Structure of wild-type substrate free SARS-CoV-2 Mpro.
X-ray diffraction
1.8
33208735
3D view