Reference News Articles

Last updated: 2021 Jun 23
Total row(s): 78
Date of Publish
Newspaper/ Channel
Title
Summary
Journal
Reference paper Title
Reference paper Author
Organisation
Level of relevance
Category
2021 Jan 19
Science Daily
Study identifies a nonhuman primate model that mimics severe COVID-19 similar to humans
Aged, wild-caught African green monkeys exposed to the SARS-CoV-2 virus developed acute respiratory distress syndrome (ARDS) with clinical symptoms similar to those observed in the most serious human cases of COVID-19, report researchers in The American Journal of Pathology, published by Elsevier. This is the first study to show that African green monkeys can develop severe clinical disease after SARS-CoV-2 infection, suggesting that they may be useful models for the study of COVID-19 in humans.
The American Journal of Pathology
Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques. ( Nov 7, 2020)
Robert V. Blair
Tulane National Primate Research Center,
5
Animal Model studies
2021 Apr 12
The scientist
Seizures Common in Hospitalized COVID-19 Patients
About 10 percent of COVID-19 patients who experienced cognitive symptoms and who were hospitalized during the early days of the pandemic experienced nonconvulsive seizures.
Annals of Neurology
Electroencephalographic abnormalities are common in COVID-19 and are associated with outcomes.
L. Lin,shafi MM
5
clinical management
2021 May 04
Science Daily
People with disabilities faced pandemic triage biases
Disaster Medicine and Public Health Preparedness
Discrimination and Bias in State Triage Protocols Towards Populations with Intellectual Disabilities During the COVID-19 Pandemic.
Ashley Brooke Felt, Dionne Mitcham, Morgan Hathcock, Raymond Swienton, Curtis Harris
University of Georgia.
4
clinical management
2020 Oct 20
BioSpectrum
IIT Kgp commercialises COVID-19 diagnostic device COVIRAP
A new low-cost Covid-19 diagnostic method named COVIRAP, developed by the Indian Institute of Technology (IIT), Kharagpur.
Professor Suman Chakraborty, Dr. Arindam Mondal
IIT, Kharagpur
5
Diagnostics
2021 Apr 21
The Hindu
Global Launch of COVIRAP – Nucleic acid-based Point-of-Care Diagnostic Device for COVID-19 and beyond.IIT Kharagpur launches COVIRAP diagnostic technology
Global Launch of COVIRAP – Nucleic acid-based Point-of-Care Diagnostic Device for COVID-19 and beyond. generic step-wise isothermal nucleic acid-based testing technology for the rapid diagnostics of pathogenic infections including but not limited to SARS-CoV-2 in individuals.Nasal Swab/ Saliva to result from integration in about 45 minutes in a highly affordable pre-programmable portable device developed by the team, without requiring any separate facility for RNA extraction.ead researchers Professor Suman Chakraborty, Dr. Arindam Mondal and their research group has been licensed for commercialization to the Rapid Diagnostic Group of Companies, India and Bramerton Holdings LLC, USA
Professor Suman Chakraborty, Dr. Arindam Mondal
IIT, Kharagpur
5
Diagnostics
2020 Dec 07
Science Daily
Paper-based electrochemical sensor can detect COVID-19 in less than five minutes
Reported a rapid, ultrasensitive test using a paper-based electrochemical sensor to detect the presence of the virus in less than five minutes.
ACS Nano
Rapid, Ultrasensitive, and Quantitative Detection of SARS-CoV-2 Using Antisense Oligonucleotides Directed Electrochemical Biosensor Chip.
Maha Alafeef, Ketan Dighe, Parikshit Moitra, Dipanjan Pan.
University of Illinois Grainger College of Engineering
5
Diagnostics
2021 May 12
Science Daily
Rapid COVID-19 diagnostic test delivers results within 4 minutes with 90 percent accuracy
This study reports a rapid and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0) which provides a result within 4 minutes. The RAPID technology is based on electrochemical impedance spectroscopy (EIS), which transforms the binding event between the SARS-CoV-2 spike protein and receptor protein ACE2 into a detected electrical signal. The signal can be read through a desktop instrument or a smartphone.
Matter
Low-cost Biosensor for Rapid Detection of SARS-CoV-2 at the Point-of-Care
Marcelo D.T. Torres, William R. de Araujo, Lucas F. de Lima, Andre L. Ferreira, Cesar de la Fuente-Nunez.
University of Pennsylvania School of Medicine.
5
Diagnostics
2021 May 12
Science Daily
Artificial intelligence tool uses chest X-ray to differentiate worst cases of COVID-19
In this study, researchers developed an artificial-intelligence-based effective tool that analyzes patients' chest X-ray patterns and quickly identifies COVID-19 patients' severity.
npj Digital Medicine
An artificial intelligence system for predicting the deterioration of COVID-19 patients in the emergency department.
Farah E. Shamout, Yiqiu Shen, Nan Wu, Aakash Kaku, Jungkyu Park, Taro Makino, Stanisław Jastrzębski, Jan Witowski, Duo Wang, Ben Zhang, Siddhant Dogra, Meng Cao, Narges Razavian, David Kudlowitz, Lea Azour, William Moore, Yvonne W. Lui, Yindalon Aphinyanaphongs, Carlos Fernandez-Granda, Krzysztof J. Geras.
NYU Langone Health / NYU Grossman School of Medicine
5
Diagnostics
2021 May 11
Science Daily
In the blood: Which antibodies best neutralize the coronavirus in COVID-19 patients?
The Journal of Immunology
Comparative Analysis of Antigen-Specific Anti–SARS-CoV-2 Antibody Isotypes in COVID-19 Patients
Hidetsugu Fujigaki, Masato Inaba, Michiko Osawa, Saya Moriyama, Yoshimasa Takahashi, Tadaki Suzuki, Kenya Yamase, Yukihiro Yoshida, Yo Yagura, Takayoshi Oyamada, Masao Takemura, Yohei Doi, Kuniaki Saito
Fujita Health University
5
Diagnostics
2021 May 11
Science Daily
COVID-19 wastewater testing proves effective in new study
In this study, researchers have developed a protocol to detect COVID-19 in wastewater. The technique proved better at detecting initial infections. Thus, wastewater testing is potential method for detecting and controlling COVID-19 in places where people live in close quarters.
Applied and Environmental Microbiology
Development of wastewater pooled surveillance of SARS-CoV-2 from congregate living settings.
Lisa M. Colosi, Katie E. Barry, Shireen M. Kotay, Michael D. Porter, Melinda D. Poulter, Cameron Ratliff, William Simmons, Limor I. Steinberg, D. Derek Wilson, Rena Morse, Paul Zmick, Amy J. Mathers.
University of Virginia Health System
5
Diagnostics
2021 May 03
Science Daily
Human organ chips enable COVID-19 drug repurposing
An antimalarial drug, amodiaquine, was found highly effective against SARS-CoV-2 at preventing viral entry. The study was validated, in cultured cells and a small animal model of COVID-19, using infectious SARS-CoV-2 virus.
Nature Biomedical Engineering
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si, Haiqing Bai, Melissa Rodas, Wuji Cao, Crystal Yuri Oh, Amanda Jiang, Rasmus Moller, Daisy Hoagland, Kohei Oishi, Shu Horiuchi, Skyler Uhl, Daniel Blanco-Melo, Randy A. Albrecht, Wen-Chun Liu, Tristan Jordan, Benjamin E. Nilsson-Payant, Ilona Golynker, Justin Frere, James Logue, Robert Haupt, Marisa McGrath, Stuart Weston, Tian Zhang, Roberto Plebani, Mercy Soong, Atiq Nurani, Seong Min Kim, Danni Y. Zhu, Kambez H. Benam, Girija Goyal, Sarah E. Gilpin, Rachelle Prantil-Baun, Steven P. Gygi, Rani K. Powers, Kenneth E. Carlson, Matthew Frieman, Benjamin R. tenOever, Donald E. Ingber.
Wyss Institute for Biologically Inspired Engineering at Harvard
5
Drug in vitro study
2021 May 06
News Medical
Indian SARS-CoV-2 variant shows enhanced host cell entry and immune evasion
Biorxiv
SARS-CoV-2 variant B.1.617 is resistant to Bamlanivimab and evades antibodies induced by infection and vaccination (https://doi.org/10.1101/2021.05.04.442663)
Markus Hoffmann, Heike Hofmann-Winkler, et al.,
the University of Gottingen Medical Center, the Friedrich-Alexander University of Erlangen-Nurnberg and Hannover Medical School
5
Drug in vitro study, Immunology, Molecular interaction
2021 Apr 20
The hindu
Oral drug Molnupiravir effective against COVID-19 in hamsters: study
The oral drug Molnupiravir administered to hamster showed an significant decrease in coronavirus level.
Nature Communications
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
National Institutes of Health (NIH) in the U.S. and the University of Plymouth
National Institutes of Health (NIH) in the U.S. and the University of Plymouth
5
Drugs animal studies
2021 Apr 22
Science Daily
Among COVID-19 survivors, an increased risk of death, serious illness
In the study, researchers revealed that COVID-19 survivors had faced several long health problems and an increased risk of death after surviving the initial infection. They identified the major health issues that persisted in COVID-19 patients over at least six months of period.
Nature
High-dimensional characterization of post-acute sequalae of COVID-19.
Ziyad Al-Aly, Yan Xie, Benjamin Bowe
Washington University School of Medicine
5
Epidemiology
2021 Apr 29
Science Daily
Low risk of infection in babies born to mothers with COVID-19, study finds
The population-based study showed that babies born to corona-positive mothers more likely to be born early, and only a few were infected with COVID-19. Of 2,323 babies born to SARS-CoV-2 positive mothers, one-third were tested close to or just after childbirth. Only 21 babies of these women tested positive for the virus at some point during the first 28 days.
JAMA
Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes.
Mikael Norman, Lars Naver, Jonas Soderling, Mia Ahlberg, Helena Hervius Askling, Bernice Aronsson, Emma Bystrom, Jerker Jonsson, Verena Sengpiel, Jonas F. Ludvigsson, Stellan Hakansson, Olof Stephansson.
Karolinska Institutet
4
Epidemiology
2021 Apr 29
Science Daily
Many Hispanics died of COVID-19 because of work exposure, study suggests
Demographic Research,
Using race- and age-specific COVID-19 case data to investigate the determinants of the excess COVID-19 mortality burden among Hispanic Americans.
D. Phoung Do, Reanne Frank
Ohio State University
3
Epidemiology
2021 May 11
Science Daily
Pregnant women hospitalized for COVID-19 infection do not face increased risk of death, new study suggests
Pregnant women have a significantly lower mortality rate compared to non-pregnant women.
Annals of Internal Medicine
In-Hospital Mortality in a Cohort of Hospitalized Pregnant and Nonpregnant Patients With COVID-19.
Beth L. Pineles, et al
University of Maryland School of Medicine
4
Epidemiology
2021 Apr 14
Indian Express
Some children with COVID-related syndrome develop neurological symptoms
JAMA
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome
Kerri L. LaRovere et al
Boston Children’s Hospital, Boston, Massachusetts
Epidemiology, Symptoms
2021 May 03
Science Daily
Applying UV light to common disinfectants makes them safer to use, study finds
Benzalkonium chloride (BAK) is the most common active ingredient of many disinfectants used against COVID-19. It is highly toxic when used in high concentrations. Researchers found that the use of BAK followed by UVC radiation can minimize the harmful effect of BAK residues on humans and the environment.
Cutaneous and Ocular Toxicology
Neutralization of the eye and skin irritant benzalkonium chloride using UVC radiation.
Manlong Xu, Jacob G. Sivak, David J. McCanna
University of Waterloo
4
General awareness
2020 Nov 29
The Times of India
Researchers find genetic variations linked to Covid-19 severity
Researchers find genetic risk factors that make individuals more or less susceptible to severe Covid-19.
The New England Journal of Medicine.
Mining a GWAS of Severe Covid-19
Robert E. Gerszten et al.,
Beth Israel Deaconess Medical CenterBoston, MA
5
Genetics
2020 Jul 22
The Statesman
Immunity drops quickly in mild COVID-19 cases, shows new study
The researchers found a rapid drop in antibodies – the immune system proteins that help stop viruses from infecting cells in the body.
The New England Journal of Medicine.
University of California, Los Angeles
5
Immunlogy
2021 May 05
Science Daily
Our immune systems blanket the SARS-CoV-2 spike protein with antibodies
Science
Prevalent, protective, and convergent IgG recognition of SARS-CoV-2 non-RBD spike epitopes
William N. Voss, Yixuan J. Hou, Nicole V. Johnson, George Delidakis, Jin Eyun Kim, Kamyab Javanmardi, Andrew P. Horton, Foteini Bartzoka, Chelsea J. Paresi, Yuri Tanno, Chia-Wei Chou, Shawn A. Abbasi, Whitney Pickens, Katia George, Daniel R. Boutz, Dalton M. Towers, Jonathan R. McDaniel, Daniel Billick, Jule Goike, Lori Rowe, Dhwani Batra, Jan Pohl, Justin Lee, Shivaprakash Gangappa, Suryaprakash Sambhara, Michelle Gadush, Nianshuang Wang, Maria D. Person, Brent L. Iverson, Jimmy D. Gollihar, John Dye, Andrew Herbert, Ilya J. Finkelstein, Ralph S. Baric, Jason S. McLellan, George Georgiou, Jason J. Lavinder, Gregory C. Ippolito.
5
Immunlogy
2021 May 26
Mint and The new Indian Express
Mild covid-19 can induce antibodies that can last lifetime, suggests study
Nature
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans
Ali. H Ellebedy
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
5
Immunology
2021 Apr 16
Science Daily
COVID-19: Scientists identify human genes that fight infection
Interferon genes have been identified to fight SARS-CoV-2 infection. This would help to understand the severity of the viral infection.
Molecular Cell
Functional Landscape of SARS-CoV-2 Cellular Restriction
Laura Martin-Sancho et. al.,
Sanford Burnham Prebys
4
Molecular biology
1899 Dec 30
India today
Coronavirus N protein plays critical role in viral transmission, says IISER Bhopal’s research
Frontiers in cellular and infection microbiology
SARS CoV-2 Nucleoprotein Enhances the Infectivity of Lentiviral Spike Particles (https://www.frontiersin.org/articles/10.3389/fcimb.2021.663688/full) 23 April 2021
Ajit Chande et al.,
Indian Institute of Science Education and Research, Bhopal, India
5
Molecular interactions
2021 May 04
The new Indian express
Canadian researchers release first image of B.1.1.7 variant of Covid-19, exude faith in existing vaccines
PLOS
Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Sriram subramanian
Variant, structure
2021 Apr 29
The Times of India
Higher body weight linked with severe Covid-19 risk: Lancet study
Obesity is a major risk factor for adverse outcomes after infection with SARS-CoV-2. The researchers aimed to examinethis association, including interactions with demographic and behavioural characteristics, type 2 diabetes, and otherhealth conditions.
The Lancet: Diabetes and Endocrinology
Associations between body-mass index and COVID-19 severity in 6.9 million people in England: a prospective, community-based, cohort study (published APril 28 , 2021)
Carmen Piernas
University of Oxford, NuffieldDepartment of Primary CareHealth Sciences, Radcliffe and other institutions Observatory Quarter, Oxford,UK
5
Not sure of the category
2021 Apr 29
Science Daily
New cell atlas of COVID lungs reveals why SARS-CoV-2 is deadly and different
In this study, lung autopsies of COVID-19 patients revealed a detrimental trifecta of runaway inflammation, direct destruction and impaired regeneration of lung cells involved in gas exchange, and accelerated lung scarring. The researchers gave the underlying mechanisms that cause lethality, long-term complications and showed how COVID-19 differs from other infectious diseases.
Nature
A molecular single-cell lung atlas of lethal COVID-19.
Johannes C. Melms, Jana Biermann, Huachao Huang, Yiping Wang, Ajay Nair, Somnath Tagore, Igor Katsyv, Andre F. Rendeiro, Amit Dipak Amin, Denis Schapiro, Chris J. Frangieh, Adrienne M. Luoma, Aveline Filliol, Yinshan Fang, Hiranmayi Ravichandran, Mariano G. Clausi, George A. Alba, Meri Rogava, Sean W. Chen, Patricia Ho, Daniel T. Montoro, Adam E. Kornberg, Arnold S. Han, Mathieu F. Bakhoum, Niroshana Anandasabapathy, Mayte Suarez-Farinas, Samuel F. Bakhoum, Yaron Bram, Alain Borczuk, Xinzheng V. Guo, Jay H. Lefkowitch, Charles Marboe, Stephen M. Lagana, Armando Del Portillo, Emmanuel Zorn, Glen S. Markowitz, Robert F. Schwabe, Robert E. Schwartz, Olivier Elemento, Anjali Saqi, Hanina Hibshoosh, Jianwen Que, Benjamin Izar
Columbia University Irving Medical Center
5
Pathophysiology
2021 Apr 30
Science Daily
Novel coronavirus' spike protein plays additional key role in illness
Circulation Research
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
Yuyang Lei, Jiao Zhang, Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S. Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John Y-J. Shyy.
Salk Institute
5
Pathophysiology
2021 May 06
Science Daily
One third of patients hospitalized with COVID-19 have lung changes after a year
The researchers reveal that the majority of patients discharged from hospital after experiencing severe COVID-19 infection recovered to full health, although up to a third of patients' measures of lung function were still reduced. And about a quarter of patients' CT scans showed there were still small areas of change in the lungs, and this was more common in patients with more severe lung changes at the time of hospitalization.
The Lancet Respiratory Medicine,
3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study
Xiaojun Wu, Xiaofan Liu, Yilu Zhou, Hongying Yu, Ruiyun Li, Qingyuan Zhan, Fang Ni, Si Fang, Yang Lu, Xuhong Ding, Hailing Liu, Rob M Ewing, Mark G Jones, Yi Hu, Hanxiang Nie, Yihua Wang.
University of Southampton
4
Pathophysiology
2021 May 11
Science Daily
COVID-19 alters gray matter volume in the brain, new study shows
This study showed that patients with higher levels of disability had lower gray matter volume in the superior, medial, and middle frontal gyri at discharge and six months later. Covid-19 affects the frontal-temporal network through fever or lack of oxygen.
Neurobiology of Stress
Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.
Kuaikuai Duan, Enrico Premi, Andrea Pilotto, Viviana Cristillo, Alberto Benussi, Ilenia Libri, Marcello Giunta, H. Jeremy Bockholt, Jingyu Liu, Riccardo Campora, Alessandro Pezzini, Roberto Gasparotti, Mauro Magoni, Alessandro Padovani, Vince D. Calhoun.
Georgia Institute of Technology
5
Pathophysiology
2021 May 12
Science Daily
The triple threat of coronavirus
In this study, researchers revealed the mechanisms behind the quick and efficient viral replication and invasion without getting detected by the immune response. The researcher also identified the viral proteins that are involved in the process of shutting down the host machinery.
Nature
SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis.
Yaara Finkel, Avi Gluck, Aharon Nachshon, Roni Winkler, Tal Fisher, Batsheva Rozman, Orel Mizrahi, Yoav Lubelsky, Binyamin Zuckerman, Boris Slobodin, Yfat Yahalom-Ronen, Hadas Tamir, Igor Ulitsky, Tomer Israely, Nir Paran, Michal Schwartz, Noam Stern-Ginossar.
Weizmann Institute of Science
5
Pathophysiology, Genes and proteins
2021 May 05
Science Daily
Targeted methods to control SARS-CoV-2 spread
Proceedings of the Royal Society B: Biological Sciences
Five approaches to the suppression of SARS-CoV-2 without intensive social distancing
John M. Drake, Kyle Dahlin, Pejman Rohani, Andreas Handel.
University of Georgia
4
Preventive measures, General awareness
2021 May 14
Science Daily
Call for 'paradigm shift' to fight airborne spread of COVID-19 indoors
Science
A paradigm shift to combat indoor respiratory infection.
Lidia Morawska, Joseph Allen, William Bahnfleth, Philomena M. Bluyssen, Atze Boerstra, Giorgio Buonanno, Junji Cao, Stephanie J. Dancer, Andres Floto, Francesco Franchimon, Trisha Greenhalgh, Charles Haworth, Jaap Hogeling, Christina Isaxon, Jose L. Jimenez, Jarek Kurnitski, Yuguo Li, Marcel Loomans, Guy Marks, Linsey C. Marr, Livio Mazzarella, Arsen Krikor Melikov, Shelly Miller, Donald K. Milton, William Nazaroff, Peter V. Nielsen, Catherine Noakes, Jordan Peccia, Kim Prather, Xavier Querol, Chandra Sekhar, Olli Seppanen, Shin-ichi Tanabe, Julian W. Tang, Raymond Tellier, Kwok Wai Tham, Pawel Wargocki, Aneta Wierzbicka, Maosheng Yao
Queensland University of Technology
3
Preventive measures, General awareness
2021 May 04
Science Daily
Researchers identify protein 'signature' of severe COVID-19
Cell Reports Medicine
Longitudinal proteomic analysis of plasma from patients with severe COVID-19 reveal patient survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Michael R. Filbin, Arnav Mehta, Alexis M. Schneider, Kyle R. Kays, Jamey R. Guess, Matteo Gentili, Bank G. Fenyves, Nicole C. Charland, Anna L.K. Gonye, Irena Gushterova, Hargun K. Khanna, Thomas J. LaSalle, Kendall M. Lavin-Parsons, Brendan M. Lilley, Carl L. Lodenstein, Kasidet Manakongtreecheep, Justin D. Margolin, Brenna N. McKaig, Maricarmen Rojas-Lopez, Brian C. Russo, Nihaarika Sharma, Jessica Tantivit, Molly F. Thomas, Robert E. Gerszten, Graham S. Heimberg, Paul J. Hoover, David J. Lieb, Brian Lin, Debby Ngo, Karin Pelka, Miguel Reyes, Christopher S. Smillie, Avinash Waghray, Thomas E. Wood, Amanda S. Zajac, Lori L. Jennings, Ida Grundberg, Roby P. Bhattacharyya, Blair Alden Parry, Alexandra-Chloe Villani, Moshe Sade-Feldman, Nir Hacohen, Marcia B. Goldberg
Massachusetts General Hospital
5
Proteomics
2021 Apr 23
CNBC
MIT researchers say you’re no safer from Covid indoors at 6 feet or 60 feet in new study challenging social distancing policies
An MIT study showed that people who maintain 60 feet of distance from others indoors are no more protected than if they socially distanced by just 6 feet.According to the researchers, other calculations of the risk of indoor transmission have omitted too many factors to accurately quantify that risk.
PNAS
A guideline to limit indoor airborne transmission of COVID-19 (April 27, 2021)
Martin Z. Bazant , John W. M. Bush
MIT
5
Public health, Transmission
2021 Apr 21
NDTV
SARS-CoV-2 Alters Lung Cell Metabolism IIT Kharagpur Research Model Shows
A integrated genome-scale metabolic model of normal human bronchial epithelial cells (NHBE) infected with SARS-CoV-2 using gene-expression and macromolecular make-up of the virus was developed. This article reports a method for conducting genome-scale differential flux analysis (GS-DFA) in context-specific metabolic models.
PLOS Computational Biology
Genome Scale-Differential Flux Analysis reveals deregulation of lung cell metabolism on SARS-CoV-2 infection. ( April 9, 2021)
Dr Amit Ghosh, Assistant Professor, School of Energy Science and Engineering, IIT Kharagpur.Piyush Nanda
IIT, Kharagpur
5
Research model
2021 Jan 01
BBC
Covid-19: New variant 'raises R number by up to 0.7'
The new variant of Covid-19 is "hugely" more transmissible than the virus's previous version, a study has found. the new variant increases the Reproduction or R number by between 0.4 and 0.7.
Nature
Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England (published 25 March 2021) PMID 33767447
Axel Gandy et al.,
The Imperial College, London
5
Variant,Sequence
2021 May 11
Science Daily
A comprehensive map of the SARS-CoV-2 genome
In this comparative genomics study, researchers have determined complete gene annotation of the SARS-CoV-2 genome and revealed the annotated gene set and their mutation classifications.
Nature Communications
SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes.
Irwin Jungreis, Rachel Sealfon, Manolis Kellis
Massachusetts Institute of Technology
5
Sequence, Genes and Proteins
2021 May 16
News medical
SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI
The structure of SARS-CoV-2 protein Nsp was predicted using CryoEM and AI methods.
BioRxiv
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes
QBI Coronavirus Research Group Structural Biology Consortium, University of California, San Francisco, CA 94158, USA
5
Structure
2020 Nov 21
C&EN news
Structure of SARS-CoV-2 envelope protein solved by NMR
Crystal structure of E protein predicted by NMR
Nature
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers
Mei hong
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA
5
Structure
2021 May 04
Hindustan times
Canadian experts release first molecular images of B.1.1.7 variant of Covid-19
The B.1.1.7 variant, first reported by the World Health Organization (WHO) in mid-December last year, has an unusually large number of mutations
PLoS Biol
33914735 : Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Xing Zhu 1, Dhiraj Mannar 1, Shanti S Srivastava 1, Alison M Berezuk 1, Jean-Philippe Demers 1, James W Saville 1, Karoline Leopold 1, Wei Li 2, Dimiter S Dimitrov 2, Katharine S Tuttle 1, Steven Zhou , Sagar Chittori , Sriram Subramaniam
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, United States of America.
5
Variant,Structure, Molecular interactions
2021 Apr 27
News Medical
Triple mutation in SARS-CoV-2 seen in second wave of COVID-19 in India
Biorxiv
Convergent evolution of SARS-CoV-2 spike mutations, L452R, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India (https://doi.org/10.1101/2021.04.22.440932)
Cherian S. et al. (2021)
CSIR-Institute of Genomics and Integrative Biology, New Delhi, ICMR-National Institute of Virology, Pune, National Centre for Disease Control, New Delhi,
5
Variant,Structure, mutations, phylogentic analysis, molecular interactions
2021 Apr 29
News 18
Exposure to SARS-CoV-2 Spike Protein Alone Enough to Damage Lungs: Study
Study reveals that SARC-CoV-2 protein alone can induce Covid-19-like symptoms including severe inflammation of the lungs.
The findings will be presented at the American Society for Pharmacology and Experimental Therapeutics annual meeting during the virtual Experimental Biology 2021 meeting, to be held April 27-30.
Pavel Solopovhttps://www.linkedin.com/in/pavel-solopov-a9769412a/
Old Dominion University, Virginia, US
5
Structure, Symptoms
2021 Apr 26
The Statesman
IIT-Madras studying Coronavirus’ high transmission potential
Studying the high transmission rate and mortality of SARS-CoV-2, using computational tools. The team studied its two close variants — SARS-CoV and NL63.
Proteins
Why are ACE2 binding coronavirus strains SARS‐CoV/SARS‐CoV‐2 wild and NL63 mild? ( published 27 Nov 2020)33210300
M. Micheal Gromiha
IIT Madras,
5
Structure, Symptoms
2021 Jan 27
-BBC
Covid-19: Cough, fatigue, sore throat 'more common' with new variant
Prof Lawrence Young, virologist and professor of molecular oncology at the University of Warwick, said the new variant of the virus had 23 changes compared to the original Wuhan virus. The analysis is part of a long-term study to track coronavirus in the UK population, carried out jointly with Public Health England, the University of Oxford and the University of Manchester.
~
Prof Lawrence Young
University of Warwick
5
Variant,Symptoms
2020 Nov 19
Science Daily
Three reasons why COVID-19 can cause silent hypoxia
Silent hypoxia," is a condition when oxygen levels in the body are abnormally low, which can irreparably damage vital organs if gone undetected for too long.
Nature Communications
Modeling lung perfusion abnormalities to explain early COVID-19 hypoxemia.
Jacob Herrmann, Vitor Mori, Jason H. T. Bates, Bela Suki.
Boston University
5
Symptoms
2021 May 12
Science Daily
Fatigue, mood disorders associated with post-COVID-19 syndrome
In this study report, researchers revealed about the post-COVID-19 syndrome. Patients diagnosed with the post-COVID-19 syndrome, experience symptoms such as mood disorders, fatigue, and perceived cognitive impairment that can negatively affect returning to work and resuming normal activities.
Mayo Clinic Proceedings
Post COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at the Mayo Clinic and Characteristics of the Initial Patient Cohort
Greg Vanichkachorn, Richard Newcomb, Clayton T. Cowl, M. Hassan Murad, Laura Breeher, Sara Miller, Michael Trenary, Daniel Neveau, Steven Higgins.
Mayo Clinic
5
Symptoms
2021 May 11
Science Daily
Study finds 80 percent of hospitalized COVID-19 patients have neurological issues
In this study, researchers reveal the incidence, severity, and outcomes of neurological manifestations of COVID-19 disease.
JAMA Network Open,
Global Incidence of Neurological Manifestations Among Patients Hospitalized With COVID-19—A Report for the GCS-NeuroCOVID Consortium and the ENERGY Consortium
Sherry H.-Y. Chou et al
University of Pittsburgh
5
Symptoms
2021 May 03
Science Daily
Speeding new treatments
The researchers developed REDIAL-2020, an open-source online tool that rapidly screens small molecules for their potential COVID-fighting properties.
Nature Machine Intelligence
A machine learning platform to estimate anti-SARS-CoV-2 activities.
Govinda B. KC, Giovanni Bocci, Srijan Verma, Md Mahmudulla Hassan, Jayme Holmes, Jeremy J. Yang, Suman Sirimulla, Tudor I. Oprea
University of New Mexico Health Sciences Center
5
Tool (for COVID drug repurposing )
2021 Apr 03
The Indian Express
New research: Low risk of scientists passing coronavirus to bats in winter
Zoonotic transmission of SARS-CoV-2 from humans to bats is studied and found that the risk of transmission can be reduced from 65% to 88% by the use of facemasks with high filtration efficiency.
Conservation Science and Practice
Risks posed by SARS‐CoV‐2 to North American bats during winter fieldwork
Jonathan D. Cook, Evan H. C. Grant, Jeremy T. H. Coleman, Jonathan M. Sleeman, Michael C. Runge
US Geological Survey (USGS)
4
Transmission
2021 Apr 16
Business Standard
Study sheds light on ten reasons why the coronavirus is airborne: Lancet
Asymptomatic or presymptomatic transmission of SARS-CoV-2 accout for 40% of all transmissions. According to the researchers airborne mode of transmission is an important way for the spread of COVID-19 around the world.
Lancet
Ten scientific reasons in support of airborne transmission of SARS-CoV-2
Trisha GreenhalghJose L JimenezKimberly A PratherZeynep TufekciDavid FismanRobert Schooley
University of Oxford
5
Transmission
2020 Apr 13
Science Daily
Study finds remdesivir effective against a key enzyme of coronavirus that causes COVID-19
Remdesivir has found to be effective in the inhibition of SARS-CoV-2 replication.
Journal of Biological Chemistry.
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency.
Calvin J Gordon, Egor P Tchesnokov, Emma Woolner, Jason K Perry, Joy Y. Feng, Danielle P Porter, Matthias Gotte.
University of Alberta Faculty of Medicine & Dentistry
5
Treatment
2021 Apr 19
Science Daily
Multivitamins, omega-3, probiotics, vitamin D may lessen risk of positive COVID-19 test
BMJ Nutrition, Prevention & Health,
Modest effects of dietary supplements during the COVID-19 pandemic: insights from 445 850 users of the COVID-19 Symptom Study app
Panayiotis Louca, Benjamin Murray, Kerstin Klaser, Mark S Graham, Mohsen Mazidi, Emily R Leeming, Ellen Thompson, Ruth Bowyer, David A Drew, Long H Nguyen, Jordi Merino, Maria Gomez, Olatz Mompeo, Ricardo Costeira, Carole H Sudre, Rachel Gibson, Claire J Steves, Jonathan Wolf, Paul W Franks, Sebastien Ourselin, Andrew T Chan, Sarah E Berry, Ana M Valdes, Philip C Calder, Tim D Spector, Cristina Menni
4
Treatment, General awareness
2021 Apr 21
The Statesmen
UK variant ‘45% more contagious’ than original virus
The study, led by researchers from the Tel Aviv University in Israel, used a kit that tests for three different viral genes. In the British variant, one of these genes — the S gene — was erased by the mutation.
Cell reports medicine
BNT162b2 vaccination effectively prevents the rapid rise of SARS-CoV-2 variant B.1.1.7 in high-risk populations in Israel
Ariel Muntiz, Motti Gerlic
Tel Aviv University
4
Variant,Vaccination, Epidemiology
2020 Dec 31
The Times of India
Moderna Covid-19 vaccine shows 94.1 per cent efficacy in trial: Study
Efficacy of the Moderna vaccine in preventing symptomatic infection and serious illness
The New England Journal of Medicine.
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine (published 4th Feb 2021)
Lindsey R. Baden et al.,
Brigham and Women's Hospital in the US( where the trial took place )
5
vaccine
2021 Apr 28
India today
Sputnik V arrives on May 1. What makes it different?
Russian Covid-19 vaccine Sputnik V, with 91.6 per cent efficacy, will be available in India from May. While there was scepticism over Sputnik V as Russia had not shared its trial data, perceptions changed when the trial data published in The Lancet said the vaccine "appears safe and effective".
The Lancet
Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia (published 20 feb, 2021)
Denis Y Logunov, et al.,
National Research Centre for Epidemiology and Microbiology named after Honorary Academician N F Gamaleya” of the Ministry of Health of the Russian Federation, Moscow 123098, Russia
5
Vaccine
2021 Nov 05
India today
Bharat Biotech’s Covid-19 vaccine could be launched by February, says ICMR scientist
Bharat Biotech, a private company that is developing Covaxin with the government-run Indian Council of Medical Research (ICMR), had earlier said it hoped to launch the vaccine only in the second quarter of next year.
The Lancet Infectious Diseases
Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: interim results from a double-blind, randomised, multicentre, phase 2 trial, and 3-month follow-up of a double-blind, randomised phase 1 trial ( 8 March 2021
Raches Ella, Siddharth Reddy, Harsh Jogdand, Vamshi Sarangi, Brunda Ganneru, Sai Prasad, Dipankar Das, Dugyala Raju, Usha Praturi, Gajanan Sapkal, Pragya Yadav, Prabhakar Reddy, Savita Verma, Chandramani Singh, Sagar Vivek Redkar, Chandra Sekhar Gillurkar, Jitendra Singh Kushwaha, Satyajit Mohapatra, Amit Bhate, Sanjay Rai, Samiran Panda, Priya Abraham, Nivedita Gupta, Krishna Ella, Balram Bhargava, Krishna Mohan Vadrevu
Bharat Biotech
5
Vaccines
2021 Apr 28
Science Daily
Only one in four people experience mild systemic side effects from COVID-19 vaccines, study finds
he Lancet Infectious Diseases
Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study
Cristina Menni, Kerstin Klaser, Anna May, Lorenzo Polidori, Joan Capdevila, Panayiotis Louca, Carole H Sudre, Long H Nguyen, David A Drew, Jordi Merino, Christina Hu, Somesh Selvachandran, Michela Antonelli, Benjamin Murray, Liane S Canas, Erika Molteni, Mark S Graham, Marc Modat, Amit D Joshi, Massimo Mangino, Alexander Hammers, Anna L Goodman, Andrew T Chan, Jonathan Wolf, Claire J Steves, Ana M Valdes, Sebastien Ourselin, Tim D Spector.
King's College London
5
Vaccines
2021 May 11
Science Daily
COVID-19 vaccine does not damage the placenta in pregnancy
In this research study, it is found that Moderna or Pfizer vaccines are safe in pregnancy. No vaccines related injury was found in pregnant women.
Obstetrics & Gynecology
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination in Pregnancy.
Elisheva D. Shanes, Sebastian Otero, Leena B. Mithal, Chiedza A. Mupanomunda, Emily S. Miller, Jeffery A. Goldstein.
Northwestern University
5
Vaccines
2021 May 06
Science Daily
COVID-19 vaccine is associated with fewer asymptomatic SARS-CoV-2 infections, study finds
JAMA
Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce.
Li Tang, Diego R. Hijano, Aditya H. Gaur, Terrence L. Geiger, Ellis J. Neufeld, James M. Hoffman, Randall T. Hayden.
St. Jude Children's Research Hospital
4
Vaccines
2021 May 12
Science Daily
Delaying second COVID vaccine dose may prevent deaths under certain conditions
In this study, researchers revealed that delay in the second dose of vaccine can decrease cumulative mortality, infections, and hospital admissions rate.
BMJ Nutrition, Prevention & Health,
Public health impact of delaying second dose of BNT162b2 or mRNA-1273 covid-19 vaccine: simulation agent based modeling study.
Santiago Romero-Brufau, Ayush Chopra, Alex J Ryu, Esma Gel, Ramesh Raskar, Walter Kremers, Karen S Anderson, Jayakumar Subramanian, Balaji Krishnamurthy, Abhishek Singh, Kalyan Pasupathy, Yue Dong, John C O’Horo, Walter R Wilson, Oscar Mitchell, Thomas C Kingsley.
BMJ
4
Vaccines, Epidemiology
2021 May 13
Science Daily
COVID-19 mRNA vaccines are immunogenic in pregnant and lactating women, study finds
In this study, researchers found that Pfizer or Moderna vaccines triggered immune responses in pregnant and lactating women. The vaccine-elicited antibodies were detected in both infant cord blood and breast milk. Thus, suggesting that vaccinating pregnant mothers may potentially protect infants from COVID-19 infection. It was also found that both pregnant and non-pregnant women developed cross-reactive immune responses against the COVID-19 variants of concern B.1.1.7 and B.1.351.
JAMA
Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women.
Ai-ris Y. Collier, Katherine McMahan, Jingyou Yu, Lisa H. Tostanoski, Ricardo Aguayo, Jessica Ansel, Abishek Chandrashekar, Shivani Patel, Esther Apraku Bondzie, Daniel Sellers, Julia Barrett, Owen Sanborn, Huahua Wan, Aiquan Chang, Tochi Anioke, Joseph Nkolola, Connor Bradshaw, Catherine Jacob-Dolan, Jared Feldman, Makda Gebre, Erica N. Borducchi, Jinyan Liu, Aaron G. Schmidt, Todd Suscovich, Caitlyn Linde, Galit Alter, Michele R. Hacker, Dan H. Barouch.
Beth Israel Deaconess Medical Center.
5
Vaccines, immunology
2021 May 10
Science Daily
New vaccine blocks COVID-19 and variants, plus other coronaviruses
Nature
Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Kevin O. Saunders, et al
Duke University Medical Center
5
Vaccines, Immunology
2021 May 10
Science Daily
The 'key' to new COVID-19 vaccine development
Frontiers in Immunology,
A Structural Landscape of Neutralizing Antibodies Against SARS-CoV-2 Receptor Binding Domain.
Ling Niu, Kathryn N. Wittrock, Gage C. Clabaugh, Vikram Srivastava, Michael W. Cho
Iowa State University
5
Vaccines, Immunology
2021 May 02
News Medical
Previously infected vaccinees broadly neutralize SARS-CoV-2 variants of concern
Medrixv
Previously infected vaccinees broadly neutralize SARS-CoV-2 variants
Hans C. Leier et al.,
Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Division of Infectious Diseases, Oregon Health & Science University
5
Vaccines, immunology, variants
2021 May 07
News Medical
Pfizer-BioNTech mRNA vaccine reduces both symptomatic and asymptomatic COVID-19 infection in case study
JAMA
Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce.(https://doi.org/10.1001/jama.2021.6564)
Tang, L et al.,
5
Vaccines, symptoms
2021 May 08
News Medical
Increased heart rate as a physiological response to SARS-CoV-2 mRNA vaccine
medRxiv 2021, doi: https://doi.org/10.1101/2021.05.03.21256482
The Physiologic Response to COVID-19 Vaccination.
Quer G., et al.
Scripps Research Translational Institute in California, USA,
5
Vaccines, Symptoms
2021 Apr 22
The NewYork Times
Vaccines Are Effective Against the New York Variant, Studies Find
Biorxiv (https://www.biorxiv.org/content/10.1101/2021.02.14.431043v3)
Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York
Anthony P. West Jr et al
Rockefeller University , New York
Vaccines, Variants
2021 Feb 22
NDTV
COVID-19 Variant N440K Spreading More In Southern States: Centre For Cellular And Molecular Biology
Scientists from Centre for Cellular and Molecular Biology, in a recent publication, have presented an exhaustive analysis of over 5,000 coronavirus variants in India and how they have evolved over the course of the pandemic
Biorxiv
N440K variant of SARS-CoV-2 has Higher Infectious Fitness ( https://www.biorxiv.org/content/10.1101/2021.04.30.441434v1.full.pdf)
Dixit Tandel, Divya Gupta, Vishal Sah, Krishnan Harinivas Harshan
CCMB, Hyderabad
5
Variant
2021 May 03
The scientist
What Scientists Know About the B.1.617 Coronavirus Variant
More insight into new variant/double mutant B.1.617 Coronavirus Variant.
Biorxiv
Neutralization of variant under investigation B.1.617 with sera of BBV152 vaccinees
Pragya D.yadhav
ICMR-NIV, Pune
5
Variant
1899 Dec 30
CDC recommends pregnant women get Covid vaccine after study shows it’s safe for mother and baby
Tom T. Shimabukuro
2021 May 28
Science Daily
Researchers discover drug that blocks multiple SARS-CoV-2 variants in mice
Science Immunology,
Pharmacological activation of STING blocks SARS-CoV-2 infection.
Minghua Li, Max Ferretti, Baoling Ying, Helene Descamps, Emily Lee, Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Brinda Kamalia, Lenka Dohnalova, Giulia Uhr, Hoda Zarkoob, Yu-Chi Chen, Holly Ramage, Marc Ferrer, Kristen Lynch, David C. Schultz, Christoph A. Thaiss, Michael S. Diamond, Sara Cherry
University of Pennsylvania School of Medicine
5
Drugs, Animal Studies
2021 May 28
Science Daily
Helping doctors manage COVID-19
Scientific Reports,
Towards computer-aided severity assessment via deep neural networks for geographic and opacity extent scoring of SARS-CoV-2 chest X-rays.
A. Wong, Z. Q. Lin, L. Wang, A. G. Chung, B. Shen, A. Abbasi, M. Hoshmand-Kochi, T. Q. Duong
University of Waterloo
5
Diagnostics
2021 May 26
Science Daily
Inhaled nanobodies protect hamsters from COVID-19, study finds
Science Advances,
Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses.
University of Pittsburgh
5
Drugs, Animal Studies
2021 May 26
Science Daily
Ultrasensitive blood test detects viral protein, confirms mRNA vaccine activates robust immune response
Clinical Infectious Diseases,
Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients.
Alana F Ogata, Chi-An Cheng, Michael Desjardins, Yasmeen Senussi, Amy C Sherman, Megan Powell, Lewis Novack, Salena Von, Xiaofang Li, Lindsey R Baden, David R Walt
Brigham and Women's Hospital
5
Vaccines
2021 May 25
Science Daily
Harnessing next generation sequencing to detect SARS-CoV-2 and prepare for the next pandemic
Nature Communications,
Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq.
Ramesh Yelagandula, Aleksandr Bykov, Alexander Vogt, Robert Heinen, Ezgi Ozkan, Marcus Martin Strobl, Juliane Christina Baar, Kristina Uzunova, Bence Hajdusits, Darja Kordic, Erna Suljic, Amina Kurtovic-Kozaric, Sebija Izetbegovic, Justine Schaeffer, Peter Hufnagl, Alexander Zoufaly, Tamara Seitz, Manuela Fodinger, Franz Allerberger, Alexander Stark, Luisa Cochella, Ulrich Elling
IMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences
5
Diagnostics
2021 May 25
Science Daily
A COVID-fighter's guide to T cells
Cell Host & Microbe
SARS-CoV-2 Human T cell Epitopes: adaptive immune response against COVID-19.
Alba Grifoni, John Sidney, Randi Vita, Bjoern Peters, Shane Crotty, Daniela Weiskopf, Alessandro Sette.
La Jolla Institute for Immunology
5
Immunology