Sequence : Nsp8


Total row(s): 1
Select item(s)
Key Findings
Mutation analysis of 2492 SARS-CoV-2 genomes (belonging to 58 different countries representing six continents and five different climatic zones) revealed 1516 nucleotide variations, 744 amino acid substitutions, and 12 deletion sites. The pattern of mutations was different among the six different continents (Europe, Asia, North America, South America, Africa, and Australia) and five different climatic zones (temperate, tropical, diverse, dry, and continental).
PMID 32814791
Title Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity
Author(s) nameIslam MR, Hoque MN, Rahman MS, Alam ASMRU, Akther M, Puspo JA, Akter S, Sultana M, Crandall KA, Hossain MA.
Journal Sci Rep
Impact factor4.12
Citation count17
Date of publishing2020 Aug 19

Structure : Nsp8


Total row(s): 5
Select item(s)
Key Findings
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structure of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex in its active form consisting of nsp12, nsp8, nsp7, and duplex RNA.
PMID 32438371
Title Structure of replicating SARS-CoV-2 polymerase
Author(s) nameHillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P.
Journal Nature
Impact factor24.36
Citation count74
Date of publishing2020 Aug
Structural characterization of cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26
Structural characteirzation of the nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26

Molecular_interactions : Nsp8


Total row(s): 2
Select item(s)
Key Findings
Structural characterization of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex in its active form consisting of nsp12, nsp8, nsp7 and duplex RNA.
PMID 32438371
Title Structure of replicating SARS-CoV-2 polymerase
Author(s) nameHillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P.
Journal Nature
Impact factor24.36
Citation count74
Date of publishing2020 Aug
Molecular interactions of SARS-CoV-2 RdRp in complex with a 50-base template-primer RNA and remdesivir.
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26