Sequence : Nsp13


Total row(s): 2
Select item(s)
Key Findings
Most frequent and prevalent mutation reported, with reference to Wuhan sequence (hCoV-19/Wuhan/WIV04/2019), was P323L in the non-structural protein 12 (94.7%) whereas the second frequent mutation was D614G in the Spike glycoprotein region (92.6%), followed by G71S in the non-structural protein 5 (70%).
PMID 33359061
Title Molecular epidemiology of COVID-19 in Oman: A molecular andsurveillance study for the early transmission of COVID-19 in thecountry
Author(s) nameAl-Mahruqi S, Al-Wahaibi A, Khan AL, Al-Jardani A, Asaf S, Alkindi H, Al-Kharusi S, Al-Rawahi AN, Al-Rawahi A, Al-Salmani M, Al-Shukri I, Al-Busaidi A, Al-Abri SS, Al-Harrasi A.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 21
Compared to the SARS-CoV-2 reference genome (MN908947.3), the SARS-CoV-2 isolate, CHRF_nCoV19_0001/Bangladesh (accession number: MT476385), was observed to have nine mutations.
PMID 32527780
Title Complete Genome Sequence of a Novel Coronavirus (SARS-CoV-2) Isolate from Bangladesh
Author(s) nameSaha S, Malaker R, Sajib MSI, Hasanuzzaman M, Rahman H, Ahmed ZB, Islam MS, Islam M, Hooda Y, Ahyong V, Vanaerschot M, Batson J, Hao S, Kamm J, Kistler A, Tato CM, DeRisi JL, Saha SK.
Journal Microbiol Resour Announc
Impact factor0.88
Citation count4
Date of publishing2020 Jun 11

Structure : Nsp13


Total row(s): 2
Select item(s)
Key Findings
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18

Drugs : Nsp13


Total row(s): 2
Select item(s)
Key Findings
In-silico models of Nsp13 helicase and nsp14 were generated using comparative homology modelling. The structures were validated and then used for virtual screening of pre-existing, FDA approved antiviral drugs.This was done to verify that these drugs could be repurposed to be used against SARS-CoV-2 infection.
PMID 32875166
Title In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
Author(s) nameGurung AB.
Journal Gene Rep
Impact factor0.61
Citation count5
Date of publishing2020 Dec
Virtual screening of 970 000 chemical compounds against the ATP-binding site to identify potential inhibitors indicates two of the top drug hits (Cepharanthine,Lumacaftor) have significant activity in inhibiting purified recombinant SARS-CoV-2 helicase.
PMID 33052685
Title Discovery of COVID-19 Inhibitors Targeting the SARS-CoV-2 Nsp13 Helicase
Author(s) nameWhite MA, Lin W, Cheng X.
Journal J Phys Chem Lett
Impact factor7.33
Citation count2
Date of publishing2020 Nov 5

Molecular_interactions : Nsp13


Total row(s): 1
Select item(s)
Key Findings
Molecular interaction study of nsp13-2 and template RNA.
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18