Sequence : Nsp12


Total row(s): 8
Select item(s)
Key Findings
Phylogenetic analysis of Israeli and Non-Israeli SARS-CoV-2 sequences revealed that the Israeli SARS-CoV-2 Strain containing P681H mutation originated from the B.1.1.50 Pangolin lineage.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) nameNeta S. Zuckerman, Shay Fleishon, Efrat Bucris, Dana Bar-Ilan, Michal Linial, Itay Bar-Or, Victoria Indenbaum, Merav Weil,Ella Mendelson, Michal Mandelboim, Orna Mor
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
Metadata was analyzed to associate the frequent mutations and co-mutation patterns with COVID-19 patient status (deceased, symptomatic, mild, and asymptomatic groups).
PMID
Title Genomic surveillance and phylodynamic analyses reveal emergence of novel mutation and co-mutation patterns within SARS-CoV2 variants prevalent in India
Author(s) nameNupur Biswas, Priyanka Mallick, Sujay Krishna Maity, Debaleena Bhowmik, Arpita Ghosh Mitra, Soumen Saha, Aviral Roy, Partha Chakrabarti, Sandip Paul, Saikat Chakrabarti
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
The study reports a newly identified SARS-CoV-2 Strain from Israel. The strain included a non-synonymous mutation in the S protein: P681H (C23604A) and additional four synonymous mutations, Nsp3:C7765T, Nsp12b: C13821T, Nsp16:T21111C, and C29545A.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) name-
Journal
Impact factor
Citation count
Date of publishing-
Mutation analysis of 2213 complete genomes from six geographical regions worldwide revealed 3178 polymorphic sites. Of these polymorphic sites, 58.5% (1861 sites) were non-synonymous, compared with the reference genome, Wuhan-Hu-1. Seven frequent non-synonymous mutations were observed in the global population of SARS-CoV-2.
PMID 33572190
Title Molecular Epidemiology Surveillance of SARS-CoV-2: Mutations and Genetic Diversity One Year after Emerging
Author(s) nameFlores-Alanis A, Cruz-Rangel A, Rodríguez-Gómez F, González J, Torres-Guerrero CA, Delgado G, Cravioto A, Morales-Espinosa R.
Journal Pathogens
Impact factor3.31
Citation count1
Date of publishing2021 Feb 9
62 mutations identified, including 30 mis-sense mutations, in 22 Moroccan patient isolates showed that Spike_D614G and NSP12_P323L mutations were present in all the analyzed sequences, whereas N_G204R and N_R203K were present in 9 sequences.
PMID 33558859
Title Genetic diversity and genomic epidemiology of SARS-CoV-2 in Morocco
Author(s) nameBadaoui B, Sadki K, Talbi C, Salah D, Tazi L.
Journal Biosaf Health
Impact factorCant find
Citation count1
Date of publishing2021 Feb 3
Compared to the SARS-CoV-2 reference genome (GenBank accession number: MN996528.1), the SARS-CoV-2 genome of Bangladesh, BCSIR-NILMRC-006, (accession number: MT539159) had eight mutations. A unique mutation was observed in the non-structural protein NSP2 of the ORF1ab gene.
PMID 32972934
Title Coding-Complete Genome Sequences of Three SARS-CoV-2 Strains from Bangladesh
Author(s) nameAkter S, Banu TA, Goswami B, Osman E, Uzzaman MS, Habib MA, Jahan I, Mahmud ASM, Sarker MMH, Hossain MS, Shamsuzzaman AKM, Nafisa T, Molla MMA, Yeasmin M, Ghosh AK, Al Din SMS, Ray UC, Sajib SA, Hossain M, Khan MS.
Journal Microbiol Resour Announc
Impact factor0.88
Citation count1
Date of publishing2020 Sep 24
Compared to the SARS-CoV-2 reference genome (GenBank accession number: MN996528.1), the SARS-CoV-2 genome of Bangladesh, BCSIR-NILMRC-007, (accession number: MT539158) had six mutations.
PMID 32972934
Title Coding-Complete Genome Sequences of Three SARS-CoV-2 Strains from Bangladesh
Author(s) nameAkter S, Banu TA, Goswami B, Osman E, Uzzaman MS, Habib MA, Jahan I, Mahmud ASM, Sarker MMH, Hossain MS, Shamsuzzaman AKM, Nafisa T, Molla MMA, Yeasmin M, Ghosh AK, Al Din SMS, Ray UC, Sajib SA, Hossain M, Khan MS.
Journal Microbiol Resour Announc
Impact factor0.88
Citation count1
Date of publishing2020 Sep 24
Compared to the SARS-CoV-2 reference genome (GenBank accession number: MN996528.1), the SARS-CoV-2 genome of Bangladesh, BCSIR-NILMRC-008, (accession number: MT539160) had six mutations.
PMID 32972934
Title Coding-Complete Genome Sequences of Three SARS-CoV-2 Strains from Bangladesh
Author(s) nameAkter S, Banu TA, Goswami B, Osman E, Uzzaman MS, Habib MA, Jahan I, Mahmud ASM, Sarker MMH, Hossain MS, Shamsuzzaman AKM, Nafisa T, Molla MMA, Yeasmin M, Ghosh AK, Al Din SMS, Ray UC, Sajib SA, Hossain M, Khan MS.
Journal Microbiol Resour Announc
Impact factor0.88
Citation count1
Date of publishing2020 Sep 24

Structure : Nsp12


Total row(s): 5
Select item(s)
Key Findings
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structural characterisation of SARS-CoV-2 mini replication and transcription complex
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structure of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex in its active form consisting of nsp12, nsp8, nsp7, and duplex RNA.
PMID 32438371
Title Structure of replicating SARS-CoV-2 polymerase
Author(s) nameHillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P.
Journal Nature
Impact factor24.36
Citation count74
Date of publishing2020 Aug
Structural characterization of cryo-EM structure of the apo nsp12-nsp7-nsp8 complex
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26
Structural characteirzation of the nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP)
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26

Molecular_interactions : Nsp12


Total row(s): 3
Select item(s)
Key Findings
Molecular interaction study of nsp13-2 and template RNA.
PMID 33208736
Title Architecture of a SARS-CoV-2 mini replication and transcription complex
Author(s) nameYan L, Zhang Y, Ge J, Zheng L, Gao Y, Wang T, Jia Z, Wang H, Huang Y, Li M, Wang Q, Rao Z, Lou Z.
Journal Nat Commun
Impact factor11.8
Citation count4
Date of publishing2020 Nov 18
Structural characterization of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) complex in its active form consisting of nsp12, nsp8, nsp7 and duplex RNA.
PMID 32438371
Title Structure of replicating SARS-CoV-2 polymerase
Author(s) nameHillen HS, Kokic G, Farnung L, Dienemann C, Tegunov D, Cramer P.
Journal Nature
Impact factor24.36
Citation count74
Date of publishing2020 Aug
Molecular interactions of SARS-CoV-2 RdRp in complex with a 50-base template-primer RNA and remdesivir.
PMID 32358203
Title Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Author(s) nameYin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE.
Journal Science
Impact factor20.57
Citation count156
Date of publishing2020 Jun 26