New_variants : Spike


Total row(s): 17
Select item(s)
Key Findings
Primers and probes for multiplex RT-qPCR assay that helps in determining the spike protein mutations associated with the B.1.351 variant.
PMID -
Title Rapid and high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351.
Author(s) name
Journal
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Date of publishing2021 May 22
The B.1.621 variant of interest (VOI) was characterized. Mutation of the B.1 lineage of the SARS-CoV-2 lead to the rise and spread of the B.1.621 variants. These variants carry insertion 146N and other amino acid substitutions like Y144T, Y145S, R346K, E484K, N501Y and P681H. The mutated spike protein impacts the ligand-receptor affinity, efficiency of natural body immunity to neutralize the viral infection or even the post vaccination antibodies leading to easy and high transmission rates.
PMID -
Title Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2
Author(s) name
Journal
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Date of publishing2021 May 21
Whole genome sequencing and analysis showed that the Daxing strain shared 31 nucleotide substitutions when compared to the Wuhan sequence. Also, the 7 strains showed 28 nucleotide mutations which were first observed in the B.1.1.7 (UK variant).
PMID -
Title COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study
Author(s) name
Journal
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Date of publishing2021 May 08
The T-cell responses to the wild-type spike protein were more robust in vaccinated individuals when compared to convalescent patients.
PMID -
Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
Author(s) name
Journal
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Date of publishing2021 May 03
Decreased T-cell responses were observed in response to the spike protein from 3 variants of the virus -B.1.1.7, B.1.351, and B.1.1.248 (when compared to wildtype spike) in vaccinated individuals
PMID -
Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
Author(s) name
Journal
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Date of publishing2021 May 03
Convalescent patients showed a 4 to 6.7-fold level whereas vaccinated recipients showed a 2-fold level neutralizing sera to the B.1.427/B.1.429 variant, indicating a moderate resistance to the antibodies produced in the individuals.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Author(s) name
Journal
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Date of publishing2021 Apr 20
3 significant mutations were identified in the spike protein (L452R, W152C and S13I) of the California variant B.1.427/B.1.429 with no particular difference from non-variant lineages (B.1.427, B.1.429, other Clade 20C lineages).
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Author(s) name
Journal
Impact factor
Citation count
Date of publishing2021 Apr 20
B.1.427/B.1.429 variant found in California showed a 20% higher transmissibility and higher viral RNA loads being detected in patients compared to non-variants.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Author(s) name
Journal
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Citation count
Date of publishing2021 Apr 20
Hazard of death in association with B.1.1.7 variants was 61% higher than pre-existing variants. Women and Men aged 85 years or older with Spike-gene target failure (SGTF) samples had a higher risk of death within 28 days of test positivity, compared to those without SGTF samples.
PMID 33723411
Title Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
Author(s) nameDavies NG, Jarvis CI; CMMID COVID-19 Working Group, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH.
Journal Nature
Impact factor24.36
Citation count
Date of publishing2021 Mar 15
3 regions in England reported a higher number of cases (34.6%) with the B.1.1.7 variant. However, B.1.1.7 variant did not show higher transmission during lockdowns. But the prevalence of B.1.1.7 variant in the samples increased over the study period (from 79% to 96%) due to failure in the detection of the spike gene target in RT-PCR tests.
PMID -
Title Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
Author(s) name
Journal
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Date of publishing2021 Apr 12
The 501Y lineage (Variant 1), prevalent in early Sept and mid-Nov, was 10% and the 501Y lineage (Variant 2), circulating since late Sept, was 75% more transmissible than the 501N lineage respectively.
PMID 33413740
Title Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
Author(s) nameLeung K, Shum MH, Leung GM, Lam TT, Wu JT.
Journal Euro Surveill
Impact factor7.37
Citation count4
Date of publishing2021 Jan
The dynamic tracking of the SARS-CoV-2 shows that the D614G variant was predominant in Europe and North America but not in China. In the absence of positive selection pressure due to anti-viral drugs, human population genetics could be a possible reason for evolution of the virus.
PMID 33374416
Title Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation
Author(s) nameHuang SW, Miller SO, Yen CH, Wang SF.
Journal Genes (Basel)
Impact factor3.759
Citation count1
Date of publishing2020 Dec 24
Phylogenetic analysis was carried upon 1516 SARS-CoV-2 genome sequences using the Nextstrain pipeline version to detect the Y839 variant.
PMID 33131453
Title Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal.
Author(s) nameBorges V, Isidro J, Cortes-Martins H, Duarte S, Vieira L, Leite R, Gordo I, Caetano CP, Nunes B, Sá R, Oliveira A, Guiomar R; Portuguese network for SARS-CoV-2 genomics, Gomes JP.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count1
Date of publishing2020 Dec
12343 sequences of SARS-CoV-2 isolated from 28 countries were compared with protein sequence based on the SARS-CoV-2_Wuhan-Hu-1 sequence (GenBank accession number MN908947) which was used as a reference. 1234 mutant varieties identified were used for hierarchical clustering of the countries into three clusters.
PMID 32699345
Title SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
Author(s) nameToyoshima Y, Nemoto K, Matsumoto S, Nakamura Y, Kiyotani K.
Journal J Hum Genet
Impact factor2.942
Citation count13
Date of publishing2020 Dec
A novel SARS-CoV-2 variant called the Y839 variant was reported in Portugal, which rapidly spread throughout the country by the end of April. This novel variant was imported from Italy and was more prevalent in the northern (22%) and central regions (59%) of Portugal.
PMID 33131453
Title Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal.
Author(s) nameBorges V, Isidro J, Cortes-Martins H, Duarte S, Vieira L, Leite R, Gordo I, Caetano CP, Nunes B, Sá R, Oliveira A, Guiomar R; Portuguese network for SARS-CoV-2 genomics, Gomes JP.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count1
Date of publishing2020 Dec
Cocktails of antibodies targeting distinct non-overlapping regions of RBD significantly reduces escape mutations as compared to both single antibody treatment as well as treatment with a combination of antibodies targeting overlapping regions of RBD.
PMID 32540904
Title Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
Author(s) nameBaum A, Fulton BO, Wloga E, Copin R, Pascal KE, Russo V, Giordano S, Lanza K, Negron N, Ni M, Wei Y, Atwal GS, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA.
Journal Science
Impact factor20.57
Citation count110
Date of publishing2020 Aug 21
Pseudovirus with L452R mutation showed higher infectivity in 293T cells (6.7- to 22.5-fold increase) and HAO cell line (5.8- to 14.7-fold increase) than D614G-Pseudovirus but slightly lower infectivity than N501Y-Pseudovirus.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
Author(s) name
Journal
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Vaccine : Spike


Total row(s): 2
Select item(s)
Key Findings
In a phase 1/2 trial, NVX-CoV2373, a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine was found to be safe and elicited an immune response that exceeded levels in COVID-19 convalescent serum.
PMID 32877576
Title Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
Author(s) nameKeech C, Albert G, Cho I, Robertson A, Reed P, Neal S, Plested JS, Zhu M, Cloney-Clark S, Zhou H, Smith G, Patel N, Frieman MB, Haupt RE, Logue J, McGrath M, Weston S, Piedra PA, Desai C, Callahan K, Lewis M, Price-Abbott P, Formica N, Shinde V, Fries L, Lickliter JD, Griffin P, Wilkinson B, Glenn GM.
Journal N Engl J Med
Impact factor37.91
Citation count72
Date of publishing2020 Dec 10
In a phase 1/2 trial, NVX-CoV2373, a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine was found to be safe and elicited an immune response that exceeded levels in COVID-19 convalescent serum.
PMID 32877576
Title Phase 1-2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
Author(s) nameKeech C, Albert G, Cho I, Robertson A, Reed P, Neal S, Plested JS, Zhu M, Cloney-Clark S, Zhou H, Smith G, Patel N, Frieman MB, Haupt RE, Logue J, McGrath M, Weston S, Piedra PA, Desai C, Callahan K, Lewis M, Price-Abbott P, Formica N, Shinde V, Fries L, Lickliter JD, Griffin P, Wilkinson B, Glenn GM.
Journal N Engl J Med
Impact factor37.91
Citation count72
Date of publishing2020 Dec 10

Sequence : Spike


Total row(s): 45
Select item(s)
Key Findings
Phylogenetic analysis of Israeli and Non-Israeli SARS-CoV-2 sequences revealed that the Israeli SARS-CoV-2 Strain containing P681H mutation originated from the B.1.1.50 Pangolin lineage.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) nameNeta S. Zuckerman, Shay Fleishon, Efrat Bucris, Dana Bar-Ilan, Michal Linial, Itay Bar-Or, Victoria Indenbaum, Merav Weil,Ella Mendelson, Michal Mandelboim, Orna Mor
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
Mutational and Co-mutational analysis of SARS-CoV-2 Sequences from India revealed different Co-mutation patterns and clade-specific mutations across seven Indian states and one union territory during term2 (April 2020 to July 2020) and term3 (August 2020 to December 2020).
PMID
Title Genomic surveillance and phylodynamic analyses reveal emergence of novel mutation and co-mutation patterns within SARS-CoV2 variants prevalent in India
Author(s) nameNupur Biswas, Priyanka Mallick, Sujay Krishna Maity, Debaleena Bhowmik, Arpita Ghosh Mitra, Soumen Saha, Aviral Roy, Partha Chakrabarti, Sandip Paul, Saikat Chakrabarti
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
Metadata was analyzed to associate the frequent mutations and co-mutation patterns with COVID-19 patient status (deceased, symptomatic, mild, and asymptomatic groups).
PMID
Title Genomic surveillance and phylodynamic analyses reveal emergence of novel mutation and co-mutation patterns within SARS-CoV2 variants prevalent in India
Author(s) nameNupur Biswas, Priyanka Mallick, Sujay Krishna Maity, Debaleena Bhowmik, Arpita Ghosh Mitra, Soumen Saha, Aviral Roy, Partha Chakrabarti, Sandip Paul, Saikat Chakrabarti
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
The study reports a newly identified SARS-CoV-2 Strain from Israel. The strain included a non-synonymous mutation in the S protein: P681H (C23604A) and additional four synonymous mutations, Nsp3:C7765T, Nsp12b: C13821T, Nsp16:T21111C, and C29545A.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) name-
Journal
Impact factor
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Date of publishing-
Both the clusters (C1, C2) identified in the Amazon basin showed 4 mutations in the ORF1ab region and 1 mutation in the Spike gene but at different positions within the region for each cluster.
PMID 33857136
Title Deciphering the introduction and transmission of SARS-CoV-2 in the Colombian Amazon Basin
Author(s) nameBallesteros N, Muñoz M, Patiño LH, Hernández C, González-Casabianca F, Carroll I, Santos-Vega M, Cascante J, Angel A, Feged-Rivadeneira A, Palma-Cuero M, Flórez C, Gomez S, van de Guchte A, Khan Z, Dutta J, Obla A, Alshammary HA, Gonzalez-Reiche AS, Hernandez MM, Sordillo EM, Simon V, van Bakel H, Paniz-Mondolfi AE, Ramírez JD.
Journal PLoS Negl Trop Dis
Impact factor4.4
Citation count
Date of publishing2021 Apr
Complete Coding Sequence of surface glycoprotein (S) gene, reported from an immunocompromised cancer patient infected with long-term SARS-CoV-2 infection (Pittsburgh long-term infection 1).
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
62 mutations identified, including 30 mis-sense mutations, in 22 Moroccan patient isolates showed that Spike_D614G and NSP12_P323L mutations were present in all the analyzed sequences, whereas N_G204R and N_R203K were present in 9 sequences.
PMID 33558859
Title Genetic diversity and genomic epidemiology of SARS-CoV-2 in Morocco
Author(s) nameBadaoui B, Sadki K, Talbi C, Salah D, Tazi L.
Journal Biosaf Health
Impact factorCant find
Citation count1
Date of publishing2021 Feb 3
SARS-CoV-2 immunosuppressed patients had recurrent deletions in the spike glycoprotein. The deletions altered immunodominant epitope positions within the NTD of S glycoprotein and caused resistance to a neutralizing antibody.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
SARS-CoV-2 sequences from the GISAID Database (deposited from 1 December 2019 to 24 October 2020) were analyzed to identify and characterize the recurrent deletion regions in the SARS-CoV-2 spike protein.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
SARS-CoV-2 sequences from the GISAID Database were analyzed to evaluate the geographic, genetic, and temporal abundance of recurrent deletion variants of S glycoprotein.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
Phylogenetic analysis of deletion variants (red branches) and genetically diverse nondeletion variants revealed the origins of RDR variants and identified specific deletion clades/lineages.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
Mutation analysis of 59MDW SARS-CoV-2 genomes (n=37, collected from JBSA/Lackland military members and beneficiaries from May 14, 2020, to July 28, 2020) revealed 109 nucleotide changes in the coding region of the SARS-CoV-2 genome (which caused 63 unique, non-synonymous amino acid mutations), one mutation in the 5-UTR, and two mutations in the 3UTR.
PMID 33609027
Title Whole-genome Sequencing of SARS-CoV-2: Using Phylogeny and Structural Modeling to Contextualize Local Viral Evolution
Author(s) nameNazario-Toole AE, Xia H, Gibbons TF.
Journal Mil Med
Impact factor
Citation count1
Date of publishing2021 Feb 20
Mutation analysis of 59MDW SARS-CoV-2 genomes (n=37, collected from JBSA/Lackland military members and beneficiaries from May 14, 2020, to July 28, 2020) revealed 14 non-synonymous mutations in the structural proteins. The effect and the biochemical properties of all mutations were studied.
PMID 33609027
Title Whole-genome Sequencing of SARS-CoV-2: Using Phylogeny and Structural Modeling to Contextualize Local Viral Evolution
Author(s) nameNazario-Toole AE, Xia H, Gibbons TF.
Journal Mil Med
Impact factor
Citation count1
Date of publishing2021 Feb 20
Mutation analysis of 469 complete Indian SARS-CoV-2 nucleotide sequences from GenBank revealed that five proteins ORF1ab, ORF3a, S, N, and M had multiple mutations in different variants. While six proteins ORF6, ORF7a, ORF7b, ORF8, ORF10, and E had a single mutation in each variant.
PMID 33623833
Title Characterizing genomic variants and mutations in SARS-CoV-2 proteins from Indian isolates
Author(s) nameDas JK, Sengupta A, Choudhury PP, Roy S.
Journal Gene Rep
Impact factor0.61
Citation count1
Date of publishing2021 Feb 19
The in vitro mutation analysis showed that the D614G mutation changes the spike protein sorting, enhances the trafficking of spike protein to the lysosome, and thus accelerates the entry of SARS-CoV-2 in uninfected cells.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
Most frequent and prevalent mutation reported, with reference to Wuhan sequence (hCoV-19/Wuhan/WIV04/2019), was P323L in the non-structural protein 12 (94.7%) whereas the second frequent mutation was D614G in the Spike glycoprotein region (92.6%), followed by G71S in the non-structural protein 5 (70%).
PMID 33359061
Title Molecular epidemiology of COVID-19 in Oman: A molecular andsurveillance study for the early transmission of COVID-19 in thecountry
Author(s) nameAl-Mahruqi S, Al-Wahaibi A, Khan AL, Al-Jardani A, Asaf S, Alkindi H, Al-Kharusi S, Al-Rawahi AN, Al-Rawahi A, Al-Salmani M, Al-Shukri I, Al-Busaidi A, Al-Abri SS, Al-Harrasi A.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 21
The in-vitro mutation analysis revealed several deleted mutants (Del-muts) and single variants in Vero-E6 cell cultures of a SARS-CoV-2 isolate.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
Sequence alignment of residues in the 615 to 635 loop and the corresponding NTD binding pocket of representative CoV strains belonging to lineage B of Betacoronavirus.
PMID 33082295
Title Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
Author(s) nameBangaru S, Ozorowski G, Turner HL, Antanasijevic A, Huang D, Wang X, Torres JL, Diedrich JK, Tian JH, Portnoff AD, Patel N, Massare MJ, Yates JR 3rd, Nemazee D, Paulson JC, Glenn G, Smith G, Ward AB.
Journal Science
Impact factor20.57
Citation count12
Date of publishing2020 Nov 27
Phylogenetic analysis performed for the SARS-CoV-2 sequences taken from pharyngeal swabs of nine patients in Guangzhou, China indicated they were infected with the same viral strain since 100% identity was observed in Spike gene of SARS-CoV-2.
PMID 33235537
Title Community evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission through air
Author(s) nameLin G, Zhang S, Zhong Y, Zhang L, Ai S, Li K, Su W, Cao L, Zhao Y, Tian F, Li J, Wu Y, Guo C, Peng R, Wu X, Gan P, Zhu W, Lin H, Zhang Z.
Journal Atmos Environ (1994)
Impact factor4.3
Citation count1
Date of publishing2020 Nov 20
Mutation analysis of 212 SARS-CoV-2 sequences from Israel revealed 224 unique single nucleotide variants (141 non-synonymous variants, 72 synonymous variants, 11 variants in non-coding regions) and five genomic deletions at different locations.
PMID 33139704
Title Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
Author(s) nameMiller D, Martin MA, Harel N, Tirosh O, Kustin T, Meir M, Sorek N, Gefen-Halevi S, Amit S, Vorontsov O, Shaag A, Wolf D, Peretz A, Shemer-Avni Y, Roif-Kaminsky D, Kopelman NM, Huppert A, Koelle K, Stern A.
Journal Nat Commun
Impact factor11.8
Citation count9
Date of publishing2020 Nov 2
The in vitro and in vivo mutation analysis of Spike mutation D614G showed increased viral replication and viral infectivity in human cell lines (Calu-3), primary human airway tissue, and Syrian hamsters.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Comparative variant analysis of genome sequences of eleven Lebanese SARS-CoV-2 isolates revealed forty unique missense variants. Of forty unique variants identified, eighteen were new mutations.
PMID 33091548
Title Variant analysis of the first Lebanese SARS-CoV-2 isolates.
Author(s) nameAbou-Hamdan M, Hamze K, Abdel Sater A, Akl H, El-Zein N, Dandache I, Abdel-Sater F.
Journal Genomics
Impact factor
Citation count1
Date of publishing2020 Oct 20
Phylogenetic analysis of SARS-CoV-2 Spike glycoprotein protein (accession number: QIC53213.1), with ten other spike glycoprotein sequences from all the selected organisms.
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Phylogenetic analysis of human ACE2 receptor (accession number: AAT45083.1), with ACE2 receptor protein sequences from other genera of the animal kingdom.
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Antigenicity study of spike glycoprotein SARSCoV-2 sequence was analyzed to look for the abundance of antigenic peptide.
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct

Structure : Spike


Total row(s): 38
Select item(s)
Key Findings
This structure based on SARS-CoV-2 spike receptor binding domain (RBD) using computational methods predicts antibody RBD recognition signatures which can be used to design vaccine against Covid-19.
PMID
Title Structural and energetic profiling of SARS-CoV-2 antibody recognition and the impact of circulating variants
Author(s) name-
Journal
Impact factor
Citation count
Date of publishing-
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain (focused refinement of RBD and ACE2)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (focused refinement of RBD and Fab ab1)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 1)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 (focused refinement of RBD and VH ab8)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain and Fab ab1 and VH ab8
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Structural characterization of SARS-CoV-2 3Q-2P full-length prefusion spike trimer (C3 symmetry) of the leading subunit vaccine candidate (NVAX-CoV2373) from Novavax.
PMID 33082295
Title Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
Author(s) nameBangaru S, Ozorowski G, Turner HL, Antanasijevic A, Huang D, Wang X, Torres JL, Diedrich JK, Tian JH, Portnoff AD, Patel N, Massare MJ, Yates JR 3rd, Nemazee D, Paulson JC, Glenn G, Smith G, Ward AB.
Journal Science
Impact factor20.57
Citation count12
Date of publishing2020 Nov 27
Structural characterization of SARS-CoV-2 3Q-2P full-length dimers of spike trimers of the leading subunit vaccine candidate (NVAX-CoV2373) from Novavax.
PMID 33082295
Title Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate
Author(s) nameBangaru S, Ozorowski G, Turner HL, Antanasijevic A, Huang D, Wang X, Torres JL, Diedrich JK, Tian JH, Portnoff AD, Patel N, Massare MJ, Yates JR 3rd, Nemazee D, Paulson JC, Glenn G, Smith G, Ward AB.
Journal Science
Impact factor20.57
Citation count12
Date of publishing2020 Nov 27
Structure of SARS-CoV-2 Spike D614G variant without RBD.
PMID 32991842
Title Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Author(s) nameYurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J.
Journal Cell
Impact factor27.35
Citation count52
Date of publishing2020 Oct 29
Structural characterization of SARS-CoV-2 spike glycoprotein (subdomain 1 to S2 quadruple mutant (u1S2q all RBD down state)) construct.
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structural characterization of SARS-CoV-2 spike glycoprotein (subdomain 1 to S2 quadruple mutant (u1S2q 2 Up RBD state)) construct .
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation.
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structure of SARS-CoV-2 spike glycoprotein (subdomain 1 to S2 quadruple mutant (u1S2q 1 Up RBD)) .
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structure of SARS-CoV-2 rS2d (RBD to S2 double mutant ) down state spike protein trimer.
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structural characterisation of the prefusion SARS-CoV-2 spike glycoprotein.
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the prefusion spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterisation of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1)
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the prefusion spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterisation of SARS-CoV-2 spike S1 protein in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterization of the complex of Spike protein with Ty1, which is an antibody fragment that binds to the receptor binding domain (RBD) of the viral protein, and neutralizes the virus.
PMID 32887876
Title An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Author(s) nameHanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hällberg BM, Murrell B, McInerney GM.
Journal Nat Commun
Impact factor11.8
Citation count20
Date of publishing2020 Sep 4
Cryo-EM structure of the SARS-CoV-2 S protein in the prefusion conformation.
PMID 32694201
Title Distinct conformational states of SARS-CoV-2 spike protein
Author(s) nameCai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM Jr, Rawson S, Rits-Volloch S, Chen B.
Journal Science
Impact factor20.57
Citation count66
Date of publishing2020 Sep 25
Cryo-EM structure of the SARS-CoV-2 S2 in the postfusion conformation.
PMID 32694201
Title Distinct conformational states of SARS-CoV-2 spike protein
Author(s) nameCai Y, Zhang J, Xiao T, Peng H, Sterling SM, Walsh RM Jr, Rawson S, Rits-Volloch S, Chen B.
Journal Science
Impact factor20.57
Citation count66
Date of publishing2020 Sep 25
Structural characterisation of SARS-CoV-2 Spike ectodomain
PMID 32755598
Title A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2
Author(s) nameLiu YM, Shahed-Al-Mahmud M, Chen X, Chen TH, Liao KS, Lo JM, Wu YM, Ho MC, Wu CY, Wong CH, Jan JT, Ma C.
Journal Cell Rep
Impact factor7.7
Citation count7
Date of publishing2020 Aug 11

Drugs : Spike


Total row(s): 9
Select item(s)
Key Findings
Bisoxatin, a laxative compound can inhibit ACE2-Spike protein interactions
PMID 33184246
Title Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods
Author(s) nameUnni S, Aouti S, Thiyagarajan S, Padmanabhan B.
Journal J Biosci
Impact factor1.72
Citation count1
Date of publishing2020
Computational screening of 19 different inhibitor molecules by Molecular docking,drug-like and ADMETprediction indicates HIV protease, anti-inflammatory and antibiotic inhibitors are potential lead drug molecules against spike protein and antimalarial drugs show less binding affinity against spike protein.
PMID 33152616
Title Molecular screening of antimalarial, antiviral, anti-inflammatory and HIV protease inhibitors against spike glycoprotein of coronavirus
Author(s) namePrashantha CN, Gouthami K, Lavanya L, Bhavanam S, Jakhar A, Shakthiraju RG, Suraj V, Sahana KV, Sujana HS, Guruprasad NM, Ramachandra R.
Journal J Mol Graph Model
Impact factor1.93
Citation count1
Date of publishing2021 Jan
Present study was aimed to target SARS-CoV-2 S-RBD with novel bioactive compounds to retrieve potential candidates that could serve as anti-coronavirus disease 2019 drugs.
PMID 33041407
Title Promising terpenes as SARS-CoV-2 spike receptor-binding domain (RBD) attachment inhibitors to the human ACE2 receptor: Integrated computational approach
Author(s) nameMuhseen ZT, Hameed AR, Al-Hasani HMH, Tahir Ul Qamar M, Li G.
Journal J Mol Liq
Impact factor4.85
Citation count4
Date of publishing2020 Dec 15
Computational screening of more than 3800 FDA-approved drugs against RBD S1-ACE2 interface by flexible ligand docking, ADME property calculations, and protein-ligand interaction maps indicate silodosin a good inhibitor of spike protein.
PMID 33103586
Title High-throughput virtual screening of drug databanks for potential inhibitors of SARS-CoV-2 spike glycoprotein
Author(s) nameAwad IE, Abu-Saleh AAA, Sharma S, Yadav A, Poirier RA.
Journal J Biomol Struct Dyn
Impact factor3.22
Citation count1
Date of publishing2020 Oct 25
Novel peptidomimetics were designed based on crucial interacting interface residues from ACE2-SARS-CoV-2 binary interactions, the top lead peptidomimetics were screened for further validation using computational method and in that 4 lead peptidomimetic compounds shows inhibition against spike protein in cell-based assays.
PMID 33072222
Title Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein
Author(s) nameAlagumuthu M, Rajpoot S, Baig MS.
Journal Cell Mol Bioeng
Impact factor2.36
Citation count1
Date of publishing2020 Oct 13
Virtual screening and in silico pharmacophore modelling of 764913 compounds to explore safe oral drugs against Receptor Binding Domain (RBD) of SARS-CoV-2,but only eight molecules fit the criteria for safe oral drugs.
PMID 33083627
Title Computer-aided drug design against spike glycoprotein of SARS-CoV-2 to aid COVID-19 treatment
Author(s) nameShehroz M, Zaheer T, Hussain T.
Journal Heliyon
Impact factor1.65
Citation count1
Date of publishing2020 Oct
This study reports the effective treatment of Tocilizumab (TCZ) therapy in COVID-19 infected patients. In most patients, elevated CRP levels and IL-6 levels gradually decreased after TCZ therapy. For critically ill patients, repeated doses (two to three doses) of TCZ improved the health conditions.
PMID 32253759
Title Tocilizumab treatment in COVID19: A single center experience
Author(s) nameLuo P, Liu Y, Qiu L, Liu X, Liu D, Li J.
Journal J Med Virol
Impact factor2.07
Citation count351
Date of publishing2020 Jul
Stilbenoids(plant based) were repurposed and checked for biological activity against the SARS-CoV-2 spike protein and human ACE2 receptor complex. Four compounds with good affinity were found out of which Resveratol was shown to be most promising.
PMID 32345140
Title Stilbene-based natural compounds as promising drug candidates against COVID-19
Author(s) nameWahedi HM, Ahmad S, Abbasi SW.
Journal J Biomol Struct Dyn
Impact factor3.22
Citation count63
Date of publishing2020 May 12
3 inhibitors originally developed for antiviral therapy against HIV, influenza A and B and respiratory infections were chosen and investigated for their potential effectiveness and interaction affinity towards the SARS-CoV-2 Spike protein
PMID 32295237
Title Molecular Investigation of SARSCoV-2 Proteins and Their Interactions with Antiviral Drugs
Author(s) nameCalligari P, Bobone S, Ricci G, Bocedi A.
Journal Viruses
Impact factor3.76
Citation count34
Date of publishing2020 Apr 14

Diagnostics : Spike


Total row(s): 4
Select item(s)
Key Findings
A total antibody test that detects IgG and IgM concentrations against the spike protein in a single cartridge with maximum specificity
PMID 32710669
Title Validation and performance comparision of three SARS-CoV-2 antibody assays
Author(s) namePaiva KJ, Grisson RD, Chan PA, Huard RC, Caliendo AM, Lonks JR, King E, Tang EW, Pytel-Parenteau DL, Nam GH, Yakirevich E, Lu S.
Journal J Med Virol
Impact factor2.07
Citation count4
Date of publishing2021 Feb
A lateral flow assay that detects IgG and IgM antibody concentration against spike protein in two different cartridges with just maximum specificity
PMID 32710669
Title Validation and performance comparision of three SARS-CoV-2 antibody assays
Author(s) namePaiva KJ, Grisson RD, Chan PA, Huard RC, Caliendo AM, Lonks JR, King E, Tang EW, Pytel-Parenteau DL, Nam GH, Yakirevich E, Lu S.
Journal J Med Virol
Impact factor2.07
Citation count4
Date of publishing2021 Feb
Detection of SARS CoV-2 IgM, and IgA antibodies from Sera samples using Luminex bead-based assay by targeting SARS-CoV-2 spike and nucleocapsid antigens. The neutralizing and binding IgG, IgA, and IgM antibody levels were higher for severe than mild cases in the early convalescent phase (<6 weeks).
PMID 33227340
Title Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assay
Author(s) nameMariën J, Ceulemans A, Michiels J, Heyndrickx L, Kerkhof K, Foque N, Widdowson MA, Mortgat L, Duysburgh E, Desombere I, Jansens H, Van Esbroeck M, Ariën KK.
Journal J Virol Methods
Impact factor1.76
Citation count1
Date of publishing2021 Feb
This study reports a rapid and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0) which provides a result within 4 minutes. The RAPID technology is based on electrochemical impedance spectroscopy (EIS), which transforms the binding event between the SARS-CoV-2 spike protein and receptor protein ACE2 into a detected electrical signal. The signal can be read through a desktop instrument or a smartphone.
PMID 33997767
Title Low-cost Biosensor for Rapid Detection of SARS-CoV-2 at the Point-of-Care
Author(s) name
Journal
Impact factor
Citation count
Date of publishing

Molecular_interactions : Spike


Total row(s): 19
Select item(s)
Key Findings
Surface plasmon resonance (SPR) was used to compare the kinetics of SARS-CoV-2 S protein both D614 and D614G binding to human ACE2. D614G decreases the affinity for ACE2 by increasing the rate of dissociation.
PMID 32991842
Title Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Author(s) nameYurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J.
Journal Cell
Impact factor27.35
Citation count52
Date of publishing2020 Oct 29
Molecular interaction of SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain and Fab ab1 and VH ab8
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Structural characterization of SARS-CoV-2 spike glycoprotein (subdomain 1 to S2 quadruple mutant (u1S2q 1 Up RBD)) construct. And determing its binding with the antibody CR3022 and human cell receptor ACE2.
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structural characterization of SARS-CoV-2 spike glycoprotein (subdomain 1 to S2 quadruple mutant (u1S2q 2 Up RBD state)) construct and determing its binding with the antibody CR3022 human cell receptor ACE2
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Structural characterization of SARS-CoV-2 spike glycoprotein (RBD to S2 double mutant (rS2d)) constructs. And determing its binding with the antibody CR3022 and human cell receptor ACE2.
PMID 32699321
Title Controlling the SARS-CoV-2 spike glycoprotein conformation
Author(s) nameHenderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P.
Journal Nat Struct Mol Biol
Impact factor9.8
Citation count43
Date of publishing2020 Oct
Molecular interaction between the docked Spike glycoprotein of SARSCoV2 with modeled cell surface TLR6 of human.
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Molecular interactions between the docked Spike glycoprotein of SARSCoV2 with modeled cell surface TLR4 of human
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Molecular interactions between the docked Spike glycoprotein of SARSCoV2 with modeled cell surface TLR1 of human .
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Molecular interactions between the docked Spikeglycoprotein of SARSCoV2 with modeled transmembrane ACE2 receptor of human (Homo sapiens) .
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Molecular interactions between the docked Spike protein of SARSCoV2 with modeled transmembrane ACE2 receptor of bat (Rhinolophus sinicus) .
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Molecular interactions between the docked Spike glycoprotein of SARSCoV2 with modeled transmembrane ACE2 receptor of pangolin (Manis javanica)
PMID 32383269
Title In silico studies on the comparative characterization of the interactions of SARSCoV2 spike glycoprotein with ACE2 receptor homologs and human TLRs
Author(s) nameChoudhury A, Mukherjee S.
Journal J Med Virol
Impact factor2.07
Citation count32
Date of publishing2020 Oct
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterisation of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1)
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterisation of SARS-CoV-2 spike S1 protein in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Molecular interaction studies and structure simulation of human SARS-related coronavirus (SARS-CoV-2 and SARS-CoV ) and ACE2 from cat/dog/pangolin/Chinese hamster
PMID 32201080
Title Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection
Author(s) nameLuan J, Lu Y, Jin X, Zhang L.
Journal Biochem Biophys Res Commun
Impact factor2.73
Citation count80
Date of publishing2020 May 21
Structural characterization of the SARS-CoV-2 receptor-binding domain of Spike glycoprotein in complex with host Cell receptor ACE2
PMID 32225176
Title Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
Author(s) nameLan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X.
Journal Nature
Impact factor24.36
Citation count685
Date of publishing2020 May
Comparative molecular interaction study of hACE2 and Spike glycoprotein of SARS-CoV and SARS-CoV-2.
PMID 32155444
Title Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Author(s) nameWalls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D.
Journal Cell
Impact factor27.35
Citation count1310
Date of publishing2020 Apr 16
Molecular interaction and kinetics of 2019-nCoV S and angiotensin-converting enzyme 2 (ACE2)
PMID 32075877
Title Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Author(s) nameWrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS.
Journal Science
Impact factor20.57
Citation count1471
Date of publishing2020 Mar 13
A computational model of the potential molecular interactions between COVID-19 spike protein and human CD26 by selective docking.
PMID 32178593
Title Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26
Author(s) nameVankadari N, Wilce JA.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count130
Date of publishing2020

Pathophysiology : Spike


Total row(s): 12
Select item(s)
Key Findings
An acute lung injury model by intratracheally instilling the S1 subunit of SARS-CoV-2 Spike S protein (400 g/kg, 2 ml/kg body weight) in K18-hACE2 transgenic mice that overexpress the human receptor for SARS-CoV-2 Spike protein S, ACE2, and investigated outcomes 72 hours later.
PMID
Title Single intratracheal exposure to SARS-CoV-2 S1 spike protein induces acute lung injury in K18-hACE2 transgenic mice
Author(s) namePavel Solopov, Ruben Colunga Biancatelli, Elizabeth Sharlow, John Lazo, John Catravas
Journal
Impact factor
Citation count
Date of publishing
The in vitro mutation analysis showed that the D614G mutation changes the spike protein sorting, enhances the trafficking of spike protein to the lysosome.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline and dynasore.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with doxycycline and pitstop2.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with nocodazole.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
To understand the molecular mechanism of lysosomal trafficking of the spike protein, the Htet1/SD614G cells were incubated with bafilomycin A1.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
The in vitro mutation analysis of the D614G mutation showed no effect on viral replication and viral infectivity in Vero E6 cells.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Compared with the wild D614 virus, the mutant G614 virus showed increased viral replication and viral infectivity in the cell line Calu-3.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Compared with the wild D614 virus, the mutant G614 virus showed increased viral replication and viral infectivity in the primary human airway tissue culture model.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Hamsters infected with mutant SARS-CoV-2 (G614 virus) showed higher viral load in the nasal washes and the tracheae, but not in the lungs, than those of Hamsters infected with WT SARS-CoV-2 (D614 virus).
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
The in vitro analysis of the deletion variants revealed that Var1 (deletion of QTQTN in spike protein) reduced the viral replication during late-phase, and Var2 (deletion of NSPRRAR in spike protein) didnt affect viral replication in Vero and Vero-E6 cells.
PMID 32571797
Title Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2
Author(s) nameLiu Z, Zheng H, Lin H, Li M, Yuan R, Peng J, Xiong Q, Sun J, Li B, Wu J, Yi L, Peng X, Zhang H, Zhang W, Hulswit RJG, Loman N, Rambaut A, Ke C, Bowden TA, Pybus OG, Lu J.
Journal J Virol
Impact factor4.16
Citation count12
Date of publishing2020 Aug 17

Epidemiology : Spike


Total row(s): 2
Select item(s)
Key Findings
Out of 30 COVID-19 patients, 23 showed the presence of anti-N antibodies, 20 showed anti-S** antibodies, and 13 had anti-M antibodies.
PMID 33330866
Title The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike
Author(s) nameGuo C, Tsai SJ, Ai Y, Li M, Pekosz A, Cox A, Atai N, Gould SJ.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Dec 9
SARS-CoV-2 transmission was associated with the role of D614G spike protein variant as 614G had a selective advantage when compared to 614D and it relates to higher viral load and infection of younger individuals but not higher mortality or clinical severity.
PMID 33275900
Title Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
Author(s) nameVolz E, Hill V, McCrone JT, Price A, Jorgensen D, O'Toole Á, Southgate J, Johnson R, Jackson B, Nascimento FF, Rey SM, Nicholls SM, Colquhoun RM, da Silva Filipe A, Shepherd J, Pascall DJ, Shah R, Jesudason N, Li K, Jarrett R, Pacchiarini N, Bull M, Geidelberg L, Siveroni I; COG-UK Consortium, Goodfellow I, Loman NJ, Pybus OG, Robertson DL, Thomson EC, Rambaut A, Connor TR.
Journal Cell
Impact factor27.35
Citation count21
Date of publishing2020 Nov 19

Immunology : Spike


Total row(s): 84
Select item(s)
Key Findings
In-vitro neutralization assays revealed that Israeli strain containing the P681H mutation was not associated with higher infection rates and got neutralized by sera from vaccinated individuals.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) nameNeta S. Zuckerman, Shay Fleishon, Efrat Bucris, Dana Bar-Ilan, Michal Linial, Itay Bar-Or, Victoria Indenbaum, Merav Weil, Ella Mendelson, Michal Mandelboim, Orna Mor
Journal
Impact factor
Citation count
Date of publishing2021 Mar 25
Deletions at positions 144/145 and 243-244 in the NTD region of S glycoprotein disrupt the binding of antibody 4A8, which defines an immunodominant epitope within the NTD.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
Mice immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
Olive baboons immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
Using an evolutionary protein design algorithm, EvoDesign, thousands of stable S protein variants which keep the surface conformation and B cell epitopes intact were studied. The T cell epitope content and similarity score were then calculated. The newly designed S protein introduced 9 new MHC-II T cell epitopes that do not exist in the wildtype SARS-CoV-2.
PMID 33398234
Title Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
Author(s) nameOng E, Huang X, Pearce R, Zhang Y, He Y.
Journal Comput Struct Biotechnol J
Impact factor5.11
Citation count1
Date of publishing2020 Dec 31
Patients who had recovered showed increased anti-S IgG/IgM and high positive rates when compared to in-patients.
PMID 33310028
Title Dynamic Anti-Spike Protein Antibody Profiles in COVID-19 Patients
Author(s) nameBao Y, Ling Y, Chen YY, Tian D, Zhao GP, Zhang XH, Hang H, Li Y, Su B, Lu HZ, Xu J, Wang Y.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 10
During the early stages of COVID-19, total T lymphocyte count and CD4+ T cells decrease in count.
PMID 33310028
Title Dynamic Anti-Spike Protein Antibody Profiles in COVID-19 Patients
Author(s) nameBao Y, Ling Y, Chen YY, Tian D, Zhao GP, Zhang XH, Hang H, Li Y, Su B, Lu HZ, Xu J, Wang Y.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 10
The kinetics of nucleocapsid and spike specific IgM and IgG responses in ICU and non-ICU COVID-19 patients were studied.
PMID 32357808
Title Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients
Author(s) nameSun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, Peng P, Liu X, Chen Z, Huang H, Zhang F, Luo W, Niu X, Hu P, Wang L, Peng H, Huang Z, Feng L, Li F, Zhang F, Li F, Zhong N, Chen L.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count70
Date of publishing2020 Dec
14 helper T cell epitopes located in spike glycoprotein, envelope protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
34 cytotoxic T cell epitopes located in spike glycoprotein, envelope protein, membrane protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
The neutralizing potential efficiency of anti-Spike-S1 IgYs (chicken egg yolk antibodies) that blocks the binding of various variants of SARS-CoV-2 spike protein to ACE-2 receptor was researched.
PMID 33191178
Title Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
Author(s) nameWei S, Duan S, Liu X, Wang H, Ding S, Chen Y, Xie J, Tian J, Yu N, Ge P, Zhang X, Chen X, Li Y, Meng Q.
Journal Int Immunopharmacol
Impact factor3.38
Citation count1
Date of publishing2020 Nov 3
Seroconversion patterns of IgG and IgM antibodies(nucleocapsid (N) protein and spike (S) glycoprotein) in patients infected with SARS-CoV-2 show that the seroconversion time of the IgG antibody was earlier than that of IgM antibody.
PMID 32337590
Title Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Author(s) nameQu J, Wu C, Li X, Zhang G, Jiang Z, Li X, Zhu Q, Liu L.
Journal Clin Infect Dis
Impact factor7.71
Citation count56
Date of publishing2020 Nov 19
A monoclonal Antibody (2B04) potently inhibited SARS-CoV-2 infection with an IC50 of 3.007 ng/mL.
PMID 33035201
Title Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors.
Author(s) nameZeng C, Evans JP, Pearson R, Qu P, Zheng YM, Robinson RT, Hall-Stoodley L, Yount J, Pannu S, Mallampalli RK, Saif L, Oltz E, Lozanski G, Liu SL.
Journal JCI Insight
Impact factor6.014
Citation count4
Date of publishing2020 Nov 19
Studying the kinetics and antibody isotype profile to the RBD of S protein in individuals with severe infection was done along with cross-reactivity of the responses with different coronaviruses RBDs. Characterization of assay performance using the dried blood spots was done which can provide an alternative to serum or plasma.
PMID 33033172
Title Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients.
Author(s) nameIyer AS, Jones FK, Nodoushani A, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB, Charles RC.
Journal Sci Immunol
Impact factor8.16
Citation count26
Date of publishing2020 Oct 8
Sera from hamsters infected with the WT SARS-CoV-2 (D614) virus showed higher neutralization against the G614 virus than against the D614 virus.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Of the 35 monoclonal anti-bodies 'isolate', mAb 4A8 displayed high neutralizing activity against both the authentic and pseudotyped SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Of the 35 monoclonal anti-bodies isolate, mAb IM-ID2 displayed high neutralizing activity against live SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-3
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Of the 35 monoclonal anti-bodies 'isolate', mAb 0304-3H3 displayed high neutralizing activity against live SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-4
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
The percentage of S-ECD-reactive IgG+ B cells ranges from 0.56% to 11%. The percentage of plasma B cells in CD3-CD19+ B cells was 12.8%.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Monoclonal antibody MD17 showed a poor neutralizing activity (NT50) in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD29 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD67 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD45 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD65 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD62 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27