Sequence : Orf6


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Key Findings
Of 3080 SARS-CoV-2 genomes analyzed, ~1.5% genome had a rare missense mutation in three accessory proteins ORF6, ORF7b, and ORF10. The mutation caused several changes in the R-group properties of amino acids.
PMID 33619452
Title Rare mutations in the accessory proteins ORF6, ORF7b, and ORF10 of the SARS-CoV-2 genomes
Author(s) nameHassan SS, Choudhury PP, Roy B.
Journal Meta Gene
Impact factor0.88
Citation count1
Date of publishing2021 Jun
In this study, Indian SARS-CoV-2 genomes were analyzed to find out genomic variants of SARS-CoV-2 proteins. It was found that ORF1ab, S, N, and ORF3a proteins had higher variants than other SARS-CoV-2 proteins.
PMID 33623833
Title Characterizing genomic variants and mutations in SARS-CoV-2 proteins from Indian isolates
Author(s) nameDas JK, Sengupta A, Choudhury PP, Roy S.
Journal Gene Rep
Impact factor0.61
Citation count1
Date of publishing2021 Feb 19
Mutation analysis of 469 complete Indian SARS-CoV-2 nucleotide sequences from GenBank revealed 536 mutated positions within the coding regions of SARS-CoV-2 proteins.
PMID 33623833
Title Characterizing genomic variants and mutations in SARS-CoV-2 proteins from Indian isolates
Author(s) nameDas JK, Sengupta A, Choudhury PP, Roy S.
Journal Gene Rep
Impact factor0.61
Citation count1
Date of publishing2021 Feb 19
Mutation analysis of 469 complete Indian SARS-CoV-2 nucleotide sequences from GenBank revealed that five proteins ORF1ab, ORF3a, S, N, and M had multiple mutations in different variants. While six proteins ORF6, ORF7a, ORF7b, ORF8, ORF10, and E had a single mutation in each variant.
PMID 33623833
Title Characterizing genomic variants and mutations in SARS-CoV-2 proteins from Indian isolates
Author(s) nameDas JK, Sengupta A, Choudhury PP, Roy S.
Journal Gene Rep
Impact factor0.61
Citation count1
Date of publishing2021 Feb 19
Mutation analysis of 212 SARS-CoV-2 sequences from Israel revealed 224 unique single nucleotide variants (141 non-synonymous variants, 72 synonymous variants, 11 variants in non-coding regions) and five genomic deletions at different locations.
PMID 33139704
Title Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
Author(s) nameMiller D, Martin MA, Harel N, Tirosh O, Kustin T, Meir M, Sorek N, Gefen-Halevi S, Amit S, Vorontsov O, Shaag A, Wolf D, Peretz A, Shemer-Avni Y, Roif-Kaminsky D, Kopelman NM, Huppert A, Koelle K, Stern A.
Journal Nat Commun
Impact factor11.8
Citation count9
Date of publishing2020 Nov 2
Mutation analysis of 2492 SARS-CoV-2 genomes (belonging to 58 different countries representing six continents and five different climatic zones) revealed 1516 nucleotide variations, 744 amino acid substitutions, and 12 deletion sites. The pattern of mutations was different among the six different continents (Europe, Asia, North America, South America, Africa, and Australia) and five different climatic zones (temperate, tropical, diverse, dry, and continental).
PMID 32814791
Title Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity
Author(s) nameIslam MR, Hoque MN, Rahman MS, Alam ASMRU, Akther M, Puspo JA, Akter S, Sultana M, Crandall KA, Hossain MA.
Journal Sci Rep
Impact factor4.12
Citation count17
Date of publishing2020 Aug 19
Comparative genomic analysis of 15 SARS-CoV-2 genomes (representing ten countries) revealed several mutations in different genomic regions. Eight mutations in ORF1ab protein, four mutations in ORF3a protein, one mutation in ORF8, one mutation in E and N protein, and four mutations in S protein were observed. No mutations in the ORF6, ORF7a, and ORF10 regions of the genomes were found.
PMID 32773643
Title Genomic variance of Open Reading Frames (ORFs) and Spike protein in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Author(s) nameTsai PH, Wang ML, Yang DM, Liang KH, Chou SJ, Chiou SH, Lin TH, Wang CT, Chang TJ.
Journal J Chin Med Assoc
Impact factor
Citation count1
Date of publishing2020 Aug