Sequence : Nucleocapsid


Total row(s): 17
Select item(s)
Key Findings
62 mutations identified, including 30 mis-sense mutations, in 22 Moroccan patient isolates showed that Spike_D614G and NSP12_P323L mutations were present in all the analyzed sequences, whereas N_G204R and N_R203K were present in 9 sequences.
PMID 33558859
Title Genetic diversity and genomic epidemiology of SARS-CoV-2 in Morocco
Author(s) nameBadaoui B, Sadki K, Talbi C, Salah D, Tazi L.
Journal Biosaf Health
Impact factorCant find
Citation count1
Date of publishing2021 Feb 3
The second set of primer and probe sequences (YCH-N2) based on the Nucleocapsid gene developed by YCH (Yamanashi Central Hospital), used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The first set of primer and probe sequences (YCH-N1) based on the Nucleocapsid gene developed by YCH (Yamanashi Central Hospital), used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The second set of primer and probe sequences (NIID-N2) based on the Nucleocapsid gene developed by NIID, used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The first set of primer and probe sequences (NIID-N1) based on the Nucleocapsid gene developed by NIID, used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The third set of primer and probe sequences (CDC-N3) based on the Nucleocapsid gene developed by CDC, used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The second set of primer and probe sequences (CDC-N2) based on the Nucleocapsid gene developed by CDC, used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
The first set of primer and probe sequences (CDC-N1) based on the Nucleocapsid gene developed by CDC, used in real-time RT-PCR assay.
PMID 32650037
Title Double-quencher probes improve detection sensitivity toward Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in a reverse-transcription polymerase chain reaction (RT-PCR) assay
Author(s) nameHirotsu Y, Mochizuki H, Omata M.
Journal J Virol Methods
Impact factor1.76
Citation count9
Date of publishing2020 Oct
Primer and probe sequences, developed by US CDC RT-qPCR panel, specific for detecting N1 site (Nucleocapsid gene) of SARS-CoV-2.
PMID 32396505
Title US CDC Real-Time Reverse Transcription PCR Panel for detection of Severe Acute Respiratory Syndrome Coronavirus 3
Author(s) nameLu X, Wang L, Sakthivel SK, Whitaker B, Murray J, Kamili S, Lynch B, Malapati L, Burke SA, Harcourt J, Tamin A, Thornburg NJ, Villanueva JM, Lindstrom S.
Journal Emerg Infect Dis
Impact factor6.81
Citation count38
Date of publishing2020 Aug
Primer and probe sequences, developed by US CDC RT-qPCR panel, specific for detecting Nucleocapsid gene of SARS-CoV-2, SARS-CoV, and other Sarbecoviruses.
PMID 32396505
Title US CDC Real-Time Reverse Transcription PCR Panel for detection of Severe Acute Respiratory Syndrome Coronavirus 3
Author(s) nameLu X, Wang L, Sakthivel SK, Whitaker B, Murray J, Kamili S, Lynch B, Malapati L, Burke SA, Harcourt J, Tamin A, Thornburg NJ, Villanueva JM, Lindstrom S.
Journal Emerg Infect Dis
Impact factor6.81
Citation count38
Date of publishing2020 Aug
Primer and probe sequences, developed by US CDC RT-qPCR panel, specific for detecting N2 site (Nucleocapsid gene) of SARS-CoV-2.
PMID 32396505
Title US CDC Real-Time Reverse Transcription PCR Panel for detection of Severe Acute Respiratory Syndrome Coronavirus 3
Author(s) nameLu X, Wang L, Sakthivel SK, Whitaker B, Murray J, Kamili S, Lynch B, Malapati L, Burke SA, Harcourt J, Tamin A, Thornburg NJ, Villanueva JM, Lindstrom S.
Journal Emerg Infect Dis
Impact factor6.81
Citation count38
Date of publishing2020 Aug
Primer probe sequence for Nucleocapsid protein (Set No. 2) used in real-time RT-PCR
PMID 32074516
Title Development of genetic diagnostoc methods for detection for Novel Coronavirus 2019 (nCoV-2019) in Japan
Author(s) nameShirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, Katoh H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M.
Journal Jpn J Infect Dis
Impact factor1.11
Citation count72
Date of publishing2020 Jul 22
Primer probe sequence for Nucleocapsid protein (Set No.1) used in real-time RT-PCR
PMID 32074516
Title Development of genetic diagnostoc methods for detection for Novel Coronavirus 2019 (nCoV-2019) in Japan
Author(s) nameShirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, Katoh H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M.
Journal Jpn J Infect Dis
Impact factor1.11
Citation count72
Date of publishing2020 Jul 22
Multiple sequence alignment of nucleocapsid protein of coronaviruses N-terminal domain
PMID 32363136
Title Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Author(s) nameKang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, He S, Zhou Z, Zhou Z, Chen Q, Yan Y, Zhang C, Shan H, Chen S.
Journal Acta Pharm Sin B
Impact factor6.15
Citation count72
Date of publishing2020 Jul
The mutation analysis of SARS-CoV-2 genomes from 13 different countries revealed the country-specific amino acid variations in the nucleocapsid protein.
PMID 32881907
Title Comparative genome analysis of novel coronavirus (SARS-CoV-2) from different geographical locations and the effect of mutations on major target proteins: An in silico insight
Author(s) nameKhan MI, Khan ZA, Baig MH, Ahmad I, Farouk AE, Song YG, Dong JJ.
Journal PLoS One
Impact factor2.87
Citation count7
Date of publishing2020
Primer and probe sequence specific for N2 gene (Nucleocapsid gene) of SARS-CoV-2 used in RT-qPCR assay.
PMID 33338082
Title A simplified SARS-CoV-2 detection protocol for research laboratories
Author(s) namePaz S, Mauer C, Ritchie A, Robishaw JD, Caputi M.
Journal PLoS One
Impact factor2.87
Citation count1
Date of publishing2020
Primer and probe sequence specific for N1 gene(Nucleocapsid) of SARS-CoV-2 used in RT-qPCR assay.
PMID 33338082
Title A simplified SARS-CoV-2 detection protocol for research laboratories
Author(s) namePaz S, Mauer C, Ritchie A, Robishaw JD, Caputi M.
Journal PLoS One
Impact factor2.87
Citation count1
Date of publishing2020

Structure : Nucleocapsid


Total row(s): 2
Select item(s)
Key Findings
Structural characterization of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain, comparison of SARS-CoV-2 N-NTD with related viral N-NTD structures and identifying a potential unique drug target pocket in SARS-CoV-2 N-NTD
PMID 32363136
Title Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
Author(s) nameKang S, Yang M, Hong Z, Zhang L, Huang Z, Chen X, He S, Zhou Z, Zhou Z, Chen Q, Yan Y, Zhang C, Shan H, Chen S.
Journal Acta Pharm Sin B
Impact factor6.15
Citation count72
Date of publishing2020 Jul
Structural characterization of SARS-CoV-2 nucleocapsid protein N-terminal RNA binding domain, comparison of SARS-CoV-2 N-NTD with related viral N-NTD structures and identifying a potential unique drug target pocket in SARS-CoV-2 N-NTD
PMID
Title Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potential unique drug targeting sites
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Diagnostics : Nucleocapsid


Total row(s): 7
Select item(s)
Key Findings
A chemiluminescent assay that detects IgG antibodies against nucleocapsid gene with utmost specificity
PMID 32710669
Title Validation and performance comparision of three SARS-CoV-2 antibody assays
Author(s) namePaiva KJ, Grisson RD, Chan PA, Huard RC, Caliendo AM, Lonks JR, King E, Tang EW, Pytel-Parenteau DL, Nam GH, Yakirevich E, Lu S.
Journal J Med Virol
Impact factor2.07
Citation count4
Date of publishing2021 Feb
Detection of SARS CoV-2 IgM, and IgA antibodies from Sera samples using Luminex bead-based assay by targeting SARS-CoV-2 spike and nucleocapsid antigens. The neutralizing and binding IgG, IgA, and IgM antibody levels were higher for severe than mild cases in the early convalescent phase (<6 weeks).
PMID 33227340
Title Evaluating SARS-CoV-2 spike and nucleocapsid proteins as targets for antibody detection in severe and mild COVID-19 cases using a Luminex bead-based assay
Author(s) nameMariën J, Ceulemans A, Michiels J, Heyndrickx L, Kerkhof K, Foque N, Widdowson MA, Mortgat L, Duysburgh E, Desombere I, Jansens H, Van Esbroeck M, Ariën KK.
Journal J Virol Methods
Impact factor1.76
Citation count1
Date of publishing2021 Feb
In this study, a nucleocapsid protein antigen test, based on fluorescence immunochromatographic (FIC) assay, was evaluated for the rapid detection of SARS-CoV-2 N protein antigen. With RT-PCR assay as the reference standard, this assay detected SARS-CoV-2 infection in 10 minutes, with the sensitivity, specificity, and percentage agreement of 75.6%, 100%, and 80.5%, respectively.
PMID 33031947
Title Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection
Author(s) nameDiao B, Wen K, Zhang J, Chen J, Han C, Chen Y, Wang S, Deng G, Zhou H, Wu Y.
Journal Clin Microbiol Infect
Impact factor6.17
Citation count9
Date of publishing2020 Oct 5
Reporting DIOS RT-qPCR assay, which targets two regions of nucleocapsid genes (N1, N2) to detect SARS-CoV-2.
PMID 32824767
Title Direct-RT-qPCR detection of SARS-CoV-2 without RNA extraction as part of a Covid-19 testing strategy: From sample to result in one hour
Author(s) nameKriegova E, Fillerova R, Kvapil P.
Journal Diagnostics (Basel)
Impact factor2.36
Citation count3
Date of publishing2020 Aug 18
Reporting diagnostic panel developed by US CDC consists of 3 real-time reverse transcription PCR assays specific for detecting the nucleocapsid gene of SARS-COV-2.
PMID 32396505
Title US CDC Real-Time Reverse Transcription PCR Panel for detection of Severe Acute Respiratory Syndrome Coronavirus 2
Author(s) nameLu X, Wang L, Sakthivel SK, Whitaker B, Murray J, Kamili S, Lynch B, Malapati L, Burke SA, Harcourt J, Tamin A, Thornburg NJ, Villanueva JM, Lindstrom S.
Journal Emerg Infect Dis
Impact factor6.81
Citation count38
Date of publishing2020 Aug
The implementation of real-time RT-PCR for the detection of COVID-19 based on SARS-CoV-2 nucleocapsid gene set 1 and 2.
PMID 32074516
Title Development of genetic diagnostic methods for detection for Novel Coronavirus 2019 (nCoV-2019) in Japan
Author(s) nameShirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, Katoh H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M.
Journal Jpn J Infect Dis
Impact factor1.11
Citation count72
Date of publishing2020 Jul 22
In this study, a clinically useful timeline of two diagnostic tests, reverse transcriptase-polymerase chain reaction and IgM and IgG enzyme-linked immunosorbent assay is reported, by using data from several published reports for detection of COVID-19. The study revealed that the nucleocapsid and RBD-S antigens showed a high sensitivity for detecting the infection. The serological assay performed two weeks later of symptoms onset had more diagnostic accuracy.
PMID 32374370
Title Interpreting diagnostic tests for SARS CoV-2
Author(s) nameSethuraman N, Jeremiah SS, Ryo A.
Journal JAMA
Impact factor14.78
Citation count209
Date of publishing2020 Jun 9

Immunology : Nucleocapsid


Total row(s): 12
Select item(s)
Key Findings
The kinetics of nucleocapsid and spike specific IgM and IgG responses in ICU and non-ICU COVID-19 patients were studied.
PMID 32357808
Title Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients
Author(s) nameSun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, Peng P, Liu X, Chen Z, Huang H, Zhang F, Luo W, Niu X, Hu P, Wang L, Peng H, Huang Z, Feng L, Li F, Zhang F, Li F, Zhong N, Chen L.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count70
Date of publishing2020 Dec
34 cytotoxic T cell epitopes located in spike glycoprotein, envelope protein, membrane protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
14 helper T cell epitopes located in spike glycoprotein, envelope protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
Seroconversion patterns of IgG and IgM antibodies(nucleocapsid (N) protein and spike (S) glycoprotein) in patients infected with SARS-CoV-2 show that the seroconversion time of the IgG antibody was earlier than that of IgM antibody.
PMID 32337590
Title Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Author(s) nameQu J, Wu C, Li X, Zhang G, Jiang Z, Li X, Zhu Q, Liu L.
Journal Clin Infect Dis
Impact factor7.71
Citation count56
Date of publishing2020 Nov 19
The T cell response against a variety of structural and non-structural proteins revealed a coordinated and dynamic immune response. A broad range of SARS-CoV-2 proteome epitopes is recognized by the CD8+ T cell responses.
PMID 33052343
Title CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation
Author(s) nameKared H, Redd AD, Bloch EM, Bonny TS, Sumatoh H, Kairi F, Carbajo D, Abel B, Newell EW, Bettinotti MP, Benner SE, Patel EU, Littlefield K, Laeyendecker O, Shoham S, Sullivan D, Casadevall A, Pekosz A, Nardin A, Fehlings M, Tobian AA, Quinn TC.
Journal bioRxiv
Impact factorIts not a journal
Citation count2
Date of publishing2020 Oct 8
Four linear B-cell epitopes on the S and N viral proteins were identified.
PMID 32711254
Title Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity
Author(s) nameAmrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP.
Journal EBioMedicine
Impact factor6.49
Citation count9
Date of publishing2020 Aug
Two (conserved) epitopes from nucleocapsid protein of SARS-CoV-2 were identified by in silico method.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
Three (conserved) epitopes from nucleocapsid protein of SARS-CoV-2 were identified by In-silico method.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
Epitopes of bat RaTG13 coronavirus and SARS-CoV showed 100% sequence identity with SARS-CoV-2 epitopes, whereas some pangolin NC protein epitopes showed a lower identity percentage.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
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