Viral protein-human protein


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Key Findings
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8 (focused refinement of RBD and VH ab8)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (focused refinement of RBD and Fab ab1)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to Fab ab1 (class 2)
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain bound to VH ab8
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Structural characterization of S-2H2-F3a with two RBDs in up configuration and one RBD in down configuration, where each RBD is bound to 2H2 Fab.
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-2H2-F1 with one RBD in up configuration and two RBDs in down configuration, where only RBD in up configuration is bound to 2H2 Fab
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-2H2-F2 with two RBDs in up configuration and one RBD in down configuration, where each of the RBD in up configuration is bound to 2H2 Fab.
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-2H2-F3b with three RBDs in up configuration and each RBD is bound to 2H2 Fab.
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-3C1-F1 with one RBD in up configuration and two RBDs in down configuration, where the up configuration RBD is bound to 3C1 fab
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-3C1-F2 with two RBDs in up configuration and one RBD in down configuration, where the two up configuration RBD is bound to 3C1 fab.
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-3C1-F3a with two RBDs in up configuration and one RBD in down configuration, where each RBD is bound to 3C1 fab.
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterization of S-3C1-F3b with all the three RBDs in up configuration and each of them bound to 3C1 Fab
PMID 33431876
Title Development and structural basis of a two-MAb cocktail for treating SARS-CoV-2 infections
Author(s) nameZhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z.
Journal Nat Commun
Impact factor11.8
Citation count1
Date of publishing2021 Jan 11
Structural characterisation of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1)
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the prefusion spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterisation of SARS-CoV-2 spike S1 protein in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab
PMID 32585135
Title Neutralization of SARS-CoV-2 by destruction of the Prefusion Spike
Author(s) nameHuo J, Zhao Y, Ren J, Zhou D, Duyvesteyn HME, Ginn HM, Carrique L, Malinauskas T, Ruza RR, Shah PNM, Tan TK, Rijal P, Coombes N, Bewley KR, Tree JA, Radecke J, Paterson NG, Supasa P, Mongkolsapaya J, Screaton GR, Carroll M, Townsend A, Fry EE, Owens RJ, Stuart DI.
Journal Cell Host Microbe
Impact factor10.45
Citation count39
Date of publishing2020 Sep 9
Structural characterization of the crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody CR3022
PMID 32245784
Title A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Author(s) nameYuan M, Wu NC, Zhu X, Lee CD, So RTY, Lv H, Mok CKP, Wilson IA.
Journal Science
Impact factor20.57
Citation count269
Date of publishing2020 May 8
Structural characterisation of novel coronavirus spike receptor-binding domain complexed with its receptor ACE2
PMID 32275855
Title Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
Author(s) nameWang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY, Wang Q, Zhou H, Yan J, Qi J.
Journal Cell
Impact factor27.35
Citation count447
Date of publishing2020 May 14
Structural characterisation of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2
PMID 32225175
Title Structural basis of receptor recognition by SARS-CoV-2
Author(s) nameShang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F.
Journal Nature
Impact factor24.36
Citation count599
Date of publishing2020 May
Structural characterization of the SARS-CoV-2 receptor-binding domain of Spike glycoprotein in complex with host Cell receptor ACE2
PMID 32225176
Title Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
Author(s) nameLan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X.
Journal Nature
Impact factor24.36
Citation count685
Date of publishing2020 May
Structural characterization of SARS-CoV-2 RBD-ACE2-BAT1 complex in closed conformation
PMID 32132184
Title Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Author(s) nameYan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q.
Journal Science
Impact factor20.57
Citation count957
Date of publishing2020 Mar 27