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An acute lung injury model by intratracheally instilling the S1 subunit of SARS-CoV-2 Spike S protein (400 g/kg, 2 ml/kg body weight) in K18-hACE2 transgenic mice that overexpress the human receptor for SARS-CoV-2 Spike protein S, ACE2, and investigated outcomes 72 hours later.
PMID
Title Single intratracheal exposure to SARS-CoV-2 S1 spike protein induces acute lung injury in K18-hACE2 transgenic mice
Author(s) namePavel Solopov, Ruben Colunga Biancatelli, Elizabeth Sharlow, John Lazo, John Catravas
Journal
Impact factor
Citation count
Date of publishing
4 Hamsters infected with WT SARS-CoV-2 viruses (Wuhan-1) showed extensive alveolar wall destruction, alveolar space haemorrhage, and mononuclear cell infiltration in the lungs and bodyweight loss.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
4 Hamsters infected with Del-mut-1 SARS-CoV-2 viruses showed diffuse alveolar wall thickening and peribronchiolar infiltration in the lungs and no bodyweight loss.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
The virus titers in the tracheal and lung tissues of infected Hamsters showed higher virus replication in the lung tissues of hamsters infected with WT SARS-CoV-2 than Del-mut-1 variant infected hamsters.
PMID 32301390
Title Attenuated SARS-CoV-2 variants with deletions at the S1/S2 junction
Author(s) nameLau SY, Wang P, Mok BW, Zhang AJ, Chu H, Lee AC, Deng S, Chen P, Chan KH, Song W, Chen Z, To KK, Chan JF, Yuen KY, Chen H.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count36
Date of publishing2020 Dec
Hamsters infected with mutant SARS-CoV-2 (G614 virus) showed higher viral load in the nasal washes and the tracheae, but not in the lungs, than those of Hamsters infected with WT SARS-CoV-2 (D614 virus).
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Transgenic type I interferon knockout (IFNAR/-) mice, inoculated intranasally with SARS-CoV-2 showed infections in tissues including lungs, heart, stomach, intestines, liver, spleen and kidneys. Lungs with hyperemia, regional consolidation and subpleural air accumulation was observed on necropsy.
PMID 33015402
Title Characterization of local SARS-CoV-2 isolates and pathogenicity in IFNAR-/-mice
Author(s) nameHanifehnezhad A, Kehribar EŞ, Öztop S, Sheraz A, Kasırga S, Ergünay K, Önder S, Yılmaz E, Engin D, Oğuzoğlu TÇ, Şeker UÖŞ, Yılmaz E, Özkul A.
Journal Heliyon
Impact factor1.65
Citation count3
Date of publishing2020 Sep
2 young cynomolgus macaques infected with SARS-CoV-2 had 0-10% of lungs affected, hyaline membranes, alveolar oedema and leukocyte infiltration with type I & II pneumocytes affected at 4 days post-infection.
PMID 32303590
Title Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
Author(s) nameRockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, de Meulder D, van Amerongen G, van den Brand J, Okba NMA, Schipper D, van Run P, Leijten L, Sikkema R, Verschoor E, Verstrepen B, Bogers W, Langermans J, Drosten C, Fentener van Vlissingen M, Fouchier R, de Swart R, Koopmans M, Haagmans BL.
Journal Science
Impact factor20.57
Citation count197
Date of publishing2020 May 29
2 aged cynomolgus macaques infected with SARS-CoV-2 had 0-5% of lungs affected, and leukocyte infiltration with type I & II pneumocytes affected at 4 days post-infection.
PMID 32303590
Title Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model
Author(s) nameRockx B, Kuiken T, Herfst S, Bestebroer T, Lamers MM, Oude Munnink BB, de Meulder D, van Amerongen G, van den Brand J, Okba NMA, Schipper D, van Run P, Leijten L, Sikkema R, Verschoor E, Verstrepen B, Bogers W, Langermans J, Drosten C, Fentener van Vlissingen M, Fouchier R, de Swart R, Koopmans M, Haagmans BL.
Journal Science
Impact factor20.57
Citation count197
Date of publishing2020 May 29
Nasal turbinate, trachea, lungs, kidney, and intestine with acute bronchiolitis was present in infected lungs of ferrets intranasally infected with SARS-CoV-2 virus.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
12-24 months old male and female ferrets inoculated with SARS-CoV-2 virus had elevated body temperatures and reduced activity.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
12-24 months old male and female ferrets infected through direct contact with infected ferret had elevated body temperatures and reduced activity.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
12-24 months old male and female ferrets in indirect contact with infected ferrets had no change in body temperature and body weight.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
12-24 months old male and female ferrets inoculated with SARS-CoV-2 virus had highest viral RNA in nasal washes. Viral RNA was also detected in saliva specimens.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
12-24 months old male and female ferrets infected through direct contact with infected ferrets had viral RNA in nasal washes, saliva, fecal and urine samples.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13
2 out of 6 12-24 months old male and female ferrets in indirect contact with infected ferrets had viral RNA in nasal washes and fecal specimens.
PMID 32259477
Title Infection and Rapid Transmission of SARS-CoV-2 in Ferrets
Author(s) nameKim YI, Kim SG, Kim SM, Kim EH, Park SJ, Yu KM, Chang JH, Kim EJ, Lee S, Casel MAB, Um J, Song MS, Jeong HW, Lai VD, Kim Y, Chin BS, Park JS, Chung KH, Foo SS, Poo H, Mo IP, Lee OJ, Webby RJ, Jung JU, Choi YK.
Journal Cell Host Microbe
Impact factor10.45
Citation count181
Date of publishing2020 May 13