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Key Findings
Primers and probes for multiplex RT-qPCR assay that helps in determining the spike protein mutations associated with the B.1.351 variant.
PMID -
Title Rapid and high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351.
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Date of publishing2021 May 22
Primers and probes for multiplex RT-qPCR assay that helps in determining the N gene mutations associated with the B.1.1.7 variant.
PMID -
Title Rapid and high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351.
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Date of publishing2021 May 22
A multiplex RT-qPCR assay was designed to identify and differentiate between the B.1.1.7 and the B.1.351 variants. The assay can detect the B.1.1.7 specific D3L mutation and the B.1.351 specific 242-244 deletion mutation.
PMID -
Title Rapid And high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351
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Date of publishing2021 May 22
The B.1.621 variant of interest (VOI) was characterized. Mutation of the B.1 lineage of the SARS-CoV-2 lead to the rise and spread of the B.1.621 variants. These variants carry insertion 146N and other amino acid substitutions like Y144T, Y145S, R346K, E484K, N501Y and P681H. The mutated spike protein impacts the ligand-receptor affinity, efficiency of natural body immunity to neutralize the viral infection or even the post vaccination antibodies leading to easy and high transmission rates.
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Title Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2
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Date of publishing2021 May 21
A comparative cohort study was conducted on COVID 19 samples from two different variants Daxing B.1.1.7 and Shunyi B.1.470, to determine the clinical freatures of B.1.1.7 variant.
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Title COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study
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Date of publishing2021 May 08
Whole genome sequencing and analysis showed that the Daxing strain shared 31 nucleotide substitutions when compared to the Wuhan sequence. Also, the 7 strains showed 28 nucleotide mutations which were first observed in the B.1.1.7 (UK variant).
PMID -
Title COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study
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Date of publishing2021 May 08
The long term durability of antibodies from individuals vaccinated with the mRNA-1273 vaccine was assessed. The neutralisation activity of these antibodies against different SARS-CoV-2 was also studied.
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Title Modeling and Predicting Antibody Durability for mRNA-1273 Vaccine for SARS-CoV-2 Variants
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Date of publishing2021 May 04
Decreased T-cell responses were observed in response to the spike protein from 3 variants of the virus -B.1.1.7, B.1.351, and B.1.1.248 (when compared to wildtype spike) in vaccinated individuals
PMID -
Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
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Date of publishing2021 May 03
The T-cell responses to the wild-type spike protein were more robust in vaccinated individuals when compared to convalescent patients.
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Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
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Date of publishing2021 May 03
The evolutionary tree analysis shows the sequential occurrence of characteristics mutations in the B.1.1.7 variant. B.11.7 (deletion) and B.1.1.7 like (without deletion) from nine different regions were compared to examine the role of the non-coding deletion (g.a28271) in enhancing variant transmissibility.
PMID -
Title Evolutionary insights into a non-coding deletion of SARS-CoV-2 B.1.1.7
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Date of publishing2021 May 01
The evolutionary tree analysis of characteristics mutations in B.1.1.7 reveals the role of non-coding deletion (g.a.28271) in increasing the transmissibility of variant.
PMID -
Title Evolutionary insights into a non-coding deletion of SARS-CoV-2 B.1.1.7
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Date of publishing2021 May 01
The neutralizing efficacy of B.1.1.28.2 with sera obtained from COVID-19 convalescent individuals and BBV152 (Covaxin) vaccine recipients was assessed
PMID -
Title Neutralization of B.1.1.28 P2 variant with sera of natural SARS-CoV-2 infection and recipients of BBV152 vaccine
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Date of publishing2021 Apr 30
Convalescent patients showed a 4 to 6.7-fold level whereas vaccinated recipients showed a 2-fold level neutralizing sera to the B.1.427/B.1.429 variant, indicating a moderate resistance to the antibodies produced in the individuals.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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Date of publishing2021 Apr 20
3 significant mutations were identified in the spike protein (L452R, W152C and S13I) of the California variant B.1.427/B.1.429 with no particular difference from non-variant lineages (B.1.427, B.1.429, other Clade 20C lineages).
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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Date of publishing2021 Apr 20
There were no changes in the symptoms or duration of the disease in cases associated with the B.1.1.7 variant.
PMID -
Title Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
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Date of publishing2021 Apr 12
The new variant VOC - 202012/1 is considered likely to have a higher transmissible rate than other previously known variants. Moreover, S gene negative participants in the cohort study had a higher mortality rate which is exclusive of the new variant VOC - 202012/1.
PMID 33687922
Title Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study
Author(s) nameChallen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva-Atanasova K, Danon L.
Journal BMJ
Impact factor30.22
Citation count
Date of publishing2021 Mar 9
The emergence of N440K variant in several parts of India has been reported during the second wave of the pandemic. It has been concluded that the N440K variant has higher transmissibility rate than the other two prevalent strains (A2a and A3i) when they were compared on the basis of replicative fitness and infectivity.
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Title N440K variant of SARS-CoV-2 has Higher Infectious Fitness
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Date of publishing2021 Apr 30
The West Coast variant had mutations in S-protein resulting in higher rate of transmissibility than other variants prelevant at that time
PMID 33688689
Title The emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
Citation count
Date of publishing2021 Mar 3
Genome sequencing of SARS-CoV-2 samples collected from San Francisco demonstrated the increased prevalence of the West Coast variants, having mutations in S-protein and higher transmissibility rate.
PMID 33688689
Title Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
Citation count
Date of publishing2021 Mar 3
The increased prevalence of the West Coast variants in San Fransico had a higher rate of transmissibility than other variants that resulted in increased secondary household infections.
PMID 33688689
Title Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
Citation count
Date of publishing2021 Mar 3
B.1.427/B.1.429 variant found in California showed a 20% higher transmissibility and higher viral RNA loads being detected in patients compared to non-variants.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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Date of publishing2021 Apr 20
First case of SARS-CoV-2 variant was detected In Japan on January 6, 2021, which was imported from UK with 60% higher infectiousness than the original strain.
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Title Estimating SARS-CoV-2 variant strain infectiousness in Japan as of March 28, 2021
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Date of publishing2021 Apr 17
The spread of B.1.1.7 variant in Switzerland increased due to its higher transmission fitness which was 43-52% more than that of the older circulating strains. Reproductive number for B.1.1.7 variant was always above 1 while the non-B.1.1.7 strain showed a Ro below 1.
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Title Quantification of spread of SARS-CoV-2 variant B.1.1.7 in Switzerland
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Date of publishing2021 Apr 16
Hazard of death in association with B.1.1.7 variants was 61% higher than pre-existing variants. Women and Men aged 85 years or older with Spike-gene target failure (SGTF) samples had a higher risk of death within 28 days of test positivity, compared to those without SGTF samples.
PMID 33723411
Title Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
Author(s) nameDavies NG, Jarvis CI; CMMID COVID-19 Working Group, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH.
Journal Nature
Impact factor24.36
Citation count
Date of publishing2021 Mar 15
3 regions in England reported a higher number of cases (34.6%) with the B.1.1.7 variant. However, B.1.1.7 variant did not show higher transmission during lockdowns. But the prevalence of B.1.1.7 variant in the samples increased over the study period (from 79% to 96%) due to failure in the detection of the spike gene target in RT-PCR tests.
PMID -
Title Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
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Date of publishing2021 Apr 12