Mutations


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Key Findings
Primers and probes for multiplex RT-qPCR assay that helps in determining the N gene mutations associated with the B.1.1.7 variant.
PMID -
Title Rapid and high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351.
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Date of publishing2021 May 22
Primers and probes for multiplex RT-qPCR assay that helps in determining the spike protein mutations associated with the B.1.351 variant.
PMID -
Title Rapid and high throughput RT-qPCR assay for identification and differentiation between SARS-CoV-2 variants B.1.1.7 and B.1.351.
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Date of publishing2021 May 22
The B.1.621 variant of interest (VOI) was characterized. Mutation of the B.1 lineage of the SARS-CoV-2 lead to the rise and spread of the B.1.621 variants. These variants carry insertion 146N and other amino acid substitutions like Y144T, Y145S, R346K, E484K, N501Y and P681H. The mutated spike protein impacts the ligand-receptor affinity, efficiency of natural body immunity to neutralize the viral infection or even the post vaccination antibodies leading to easy and high transmission rates.
PMID -
Title Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2
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Date of publishing2021 May 21
Whole genome sequencing and analysis showed that the Daxing strain shared 31 nucleotide substitutions when compared to the Wuhan sequence. Also, the 7 strains showed 28 nucleotide mutations which were first observed in the B.1.1.7 (UK variant).
PMID -
Title COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study
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Date of publishing2021 May 08
The evolutionary tree analysis of characteristics mutations in B.1.1.7 reveals the role of non-coding deletion (g.a.28271) in increasing the transmissibility of variant.
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Title Evolutionary insights into a non-coding deletion of SARS-CoV-2 B.1.1.7
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Date of publishing2021 May 01
3 significant mutations were identified in the spike protein (L452R, W152C and S13I) of the California variant B.1.427/B.1.429 with no particular difference from non-variant lineages (B.1.427, B.1.429, other Clade 20C lineages).
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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Date of publishing2021 Apr 20
The West Coast variant had mutations in S-protein resulting in higher rate of transmissibility than other variants prelevant at that time
PMID 33688689
Title The emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
Citation count
Date of publishing2021 Mar 3
Genome sequencing of SARS-CoV-2 samples collected from San Francisco demonstrated the increased prevalence of the West Coast variants, having mutations in S-protein and higher transmissibility rate.
PMID 33688689
Title Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
Citation count
Date of publishing2021 Mar 3
Cases circulating inside households were nearly identical to the original strains while imported cases showed difference of 3 to 7 SNPs between them.
PMID 33685741
Title First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant
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Date of publishing2021 Feb 19
The emergent B.1.1.7 lineage in UK had a consistent epidemic growth and was declared as Variant of Concern(VOC).The S-gene mutations that resulted in S-gene target failures in RT-PCR(SGTF) which was characteristic to VOC lineage only.
PMID -
Title Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking B.1.1.7 in England: Insights from linking epidemiological and genetic data
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Date of publishing2021 Jan 04
Phylogenetic studies showed that VOC had unusual accumulation of substitutions in its genome and higher growth rate compared to other circulating lineages which is more due to increased transmissibility (R) rather than shorter generation time(shorter incubation period).
PMID -
Title Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking B.1.1.7 in England: Insights from linking epidemiological and genetic data
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Date of publishing2021 Jan 04
12343 sequences of SARS-CoV-2 isolated from 28 countries were compared with protein sequence based on the SARS-CoV-2_Wuhan-Hu-1 sequence (GenBank accession number MN908947) which was used as a reference. 1234 mutant varieties identified were used for hierarchical clustering of the countries into three clusters.
PMID 32699345
Title SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
Author(s) nameToyoshima Y, Nemoto K, Matsumoto S, Nakamura Y, Kiyotani K.
Journal J Hum Genet
Impact factor2.942
Citation count13
Date of publishing2020 Dec
This study focuses on the isolation of F8 strain (with E gene mutation) and 8X (wild type) from the same clinical sample and proves that a 12 bp deletion in the E gene of the SARS-COV-2 is essential for its replication and immunogenicity.
PMID 33118859
Title A SARS-CoV-2 variant with the 12-bp deletion at E gene
Author(s) nameSun YS, Xu F, An Q, Chen C, Yang ZN, Lu HJ, Chen JC, Yao PP, Jiang JM, Zhu HP.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count3
Date of publishing2020 Dec