Select item(s)
Key Findings
The new variant VOC - 202012/1 is considered likely to have a higher transmissible rate than other previously known variants. Moreover, S gene negative participants in the cohort study had a higher mortality rate which is exclusive of the new variant VOC - 202012/1.
PMID 33687922
Title Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study
Author(s) nameChallen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva-Atanasova K, Danon L.
Journal BMJ
Impact factor30.22
Citation count
Date of publishing2021 Mar 9
Hazard of death in association with B.1.1.7 variants was 61% higher than pre-existing variants. Women and Men aged 85 years or older with Spike-gene target failure (SGTF) samples had a higher risk of death within 28 days of test positivity, compared to those without SGTF samples.
PMID 33723411
Title Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
Author(s) nameDavies NG, Jarvis CI; CMMID COVID-19 Working Group, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH.
Journal Nature
Impact factor24.36
Citation count
Date of publishing2021 Mar 15
Statistical and machine learning models were used to predict whether the viral sequence variants of SARS-CoV-2 had any effect on hospitalization and mortality rates of COVID-19 patients. 289 sequence variants identified from patient samples of UW Medicine health care system was broadly classified into 2 clades. Higher rate of hospitalization was seen in Clade 2. Risk factors associated with hospitalization and deaths are patient age and comorbid conditions.
PMID 33637820
Title Hospitalization and mortality associated with SARSCoV2 viral clades in COVID19.
Author(s) nameNakamichi K, Shen JZ, Lee CS, Lee A, Roberts EA, Simonson PD, Roychoudhury P, Andriesen J, Randhawa AK, Mathias PC, Greninger AL, Jerome KR, Van Gelder RN.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2021 Feb 26
Formation of three clusters with varying degree of fatality rates were reported: Cluster 1(3.0%) , Cluster 2 (9.3%), Cluster 3 (5.8%). Highest mortality rate was associated with Cluster 2. Susceptibility to COVID-19 infections is influenced not only by SARS-CoV-2 mutations but also by BCG vaccination status and HLA genotype.
PMID 32699345
Title SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
Author(s) nameToyoshima Y, Nemoto K, Matsumoto S, Nakamura Y, Kiyotani K.
Journal J Hum Genet
Impact factor2.942
Citation count13
Date of publishing2020 Dec