Immune response


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The T-cell responses to the wild-type spike protein were more robust in vaccinated individuals when compared to convalescent patients.
PMID -
Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
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Date of publishing2021 May 03
Decreased T-cell responses were observed in response to the spike protein from 3 variants of the virus -B.1.1.7, B.1.351, and B.1.1.248 (when compared to wildtype spike) in vaccinated individuals
PMID -
Title SARS -CoV-2 T-cell immunity to variants of concern following vaccination
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Date of publishing2021 May 03
Cocktails of antibodies targeting distinct non-overlapping regions of RBD significantly reduces escape mutations as compared to both single antibody treatment as well as treatment with a combination of antibodies targeting overlapping regions of RBD.
PMID 32540904
Title Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
Author(s) nameBaum A, Fulton BO, Wloga E, Copin R, Pascal KE, Russo V, Giordano S, Lanza K, Negron N, Ni M, Wei Y, Atwal GS, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA.
Journal Science
Impact factor20.57
Citation count110
Date of publishing2020 Aug 21