Epidemiology


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The new variant VOC - 202012/1 is considered likely to have a higher transmissible rate than other previously known variants. Moreover, S gene negative participants in the cohort study had a higher mortality rate which is exclusive of the new variant VOC - 202012/1.
PMID 33687922
Title Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study
Author(s) nameChallen R, Brooks-Pollock E, Read JM, Dyson L, Tsaneva-Atanasova K, Danon L.
Journal BMJ
Impact factor30.22
Citation count
Date of publishing2021 Mar 9
The emergence of N440K variant in several parts of India has been reported during the second wave of the pandemic. It has been concluded that the N440K variant has higher transmissibility rate than the other two prevalent strains (A2a and A3i) when they were compared on the basis of replicative fitness and infectivity.
PMID -
Title N440K variant of SARS-CoV-2 has Higher Infectious Fitness
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Date of publishing2021 Apr 30
The increased prevalence of the West Coast variants in San Fransico had a higher rate of transmissibility than other variants that resulted in increased secondary household infections.
PMID 33688689
Title Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco
Author(s) namePeng J, Mann SA, Mitchell AM, Liu J, Laurie MT, Sunshine S, Pilarowski G, Ayscue P, Kistler A, Vanaerschot M, Li LM, McGeever A, Chow ED, Team I, Marquez C, Nakamura R, Rubio L, Chamie G, Jones D, Jacobo J, Rojas S, Rojas S, Tulier-Laiwa V, Black D, Martinez J, Naso J, Schwab J, Petersen M, Havlir D, DeRisi J.
Journal medRxiv
Impact factorCant find
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Date of publishing2021 Mar 3
B.1.427/B.1.429 variant found in California showed a 20% higher transmissibility and higher viral RNA loads being detected in patients compared to non-variants.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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Date of publishing2021 Apr 20
First case of SARS-CoV-2 variant was detected In Japan on January 6, 2021, which was imported from UK with 60% higher infectiousness than the original strain.
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Title Estimating SARS-CoV-2 variant strain infectiousness in Japan as of March 28, 2021
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Date of publishing2021 Apr 17
The spread of B.1.1.7 variant in Switzerland increased due to its higher transmission fitness which was 43-52% more than that of the older circulating strains. Reproductive number for B.1.1.7 variant was always above 1 while the non-B.1.1.7 strain showed a Ro below 1.
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Title Quantification of spread of SARS-CoV-2 variant B.1.1.7 in Switzerland
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Date of publishing2021 Apr 16
Hazard of death in association with B.1.1.7 variants was 61% higher than pre-existing variants. Women and Men aged 85 years or older with Spike-gene target failure (SGTF) samples had a higher risk of death within 28 days of test positivity, compared to those without SGTF samples.
PMID 33723411
Title Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7
Author(s) nameDavies NG, Jarvis CI; CMMID COVID-19 Working Group, Edmunds WJ, Jewell NP, Diaz-Ordaz K, Keogh RH.
Journal Nature
Impact factor24.36
Citation count
Date of publishing2021 Mar 15
3 regions in England reported a higher number of cases (34.6%) with the B.1.1.7 variant. However, B.1.1.7 variant did not show higher transmission during lockdowns. But the prevalence of B.1.1.7 variant in the samples increased over the study period (from 79% to 96%) due to failure in the detection of the spike gene target in RT-PCR tests.
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Title Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study
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Date of publishing2021 Apr 12
Statistical and machine learning models were used to predict whether the viral sequence variants of SARS-CoV-2 had any effect on hospitalization and mortality rates of COVID-19 patients. 289 sequence variants identified from patient samples of UW Medicine health care system was broadly classified into 2 clades. Higher rate of hospitalization was seen in Clade 2. Risk factors associated with hospitalization and deaths are patient age and comorbid conditions.
PMID 33637820
Title Hospitalization and mortality associated with SARSCoV2 viral clades in COVID19.
Author(s) nameNakamichi K, Shen JZ, Lee CS, Lee A, Roberts EA, Simonson PD, Roychoudhury P, Andriesen J, Randhawa AK, Mathias PC, Greninger AL, Jerome KR, Van Gelder RN.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2021 Feb 26
3 imported cases were reported from London to Madrid, Spain, one of which further initiated a household transmission to 3 other individuals. In addition, 2 cases were identified without epidemiological association to the UK strain, indicating independent introduction.
PMID 33685741
Title First confirmation of importation and transmission in Spain of the newly identified SARS-CoV-2 B.1.1.7 variant
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Date of publishing2021 Feb 19
The UK variant of SARS-CoV-2, B.1.1.7, which was detected in 12 U.S. states in <0.5% of the population, was known to be highly transmissible.
PMID 33476315
Title Emergence of SARS-CoV-2 B.1.1.7 Lineage United States, December 29, 2020January 12, 2021
Author(s) nameGalloway SE, Paul P, MacCannell DR, Johansson MA, Brooks JT, MacNeil A, Slayton RB, Tong S, Silk BJ, Armstrong GL, Biggerstaff M, Dugan VG.
Journal MMWR Morb Mortal Wkly Rep
Impact factor14.4
Citation count2
Date of publishing2021 Jan 22
The B.1.1.7 lineage emerged around October,2020 in UK. It had a rapid epidemic growth and higher transmissibility relative to other variants and was declared as the Variant of Concern(VOC).
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Title Transmission of SARS-CoV-2 Lineage B.1.1.7 in England: Insights from linking B.1.1.7 in England: Insights from linking epidemiological and genetic data.
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Date of publishing2021 Jan 04
The 501Y lineage (Variant 1), prevalent in early Sept and mid-Nov, was 10% and the 501Y lineage (Variant 2), circulating since late Sept, was 75% more transmissible than the 501N lineage respectively.
PMID 33413740
Title Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020
Author(s) nameLeung K, Shum MH, Leung GM, Lam TT, Wu JT.
Journal Euro Surveill
Impact factor7.37
Citation count4
Date of publishing2021 Jan
The analysis of the growth during the english chanel lockdown( Nov 5 and Dec 2 2020) revealed that the B.1.1.7 lineage spread widely (R>1) and increased during lockdown, while other lineages declined(R<1), suggesting a strong transmissibility advantage over previous circulating lineages.
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Title Lineage-specific growth of SARS-CoV-2 B.1.1.7 during the English national lockdown
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Date of publishing2020 Dec 30
The dynamic tracking of the SARS-CoV-2 shows that the D614G variant was predominant in Europe and North America but not in China. In the absence of positive selection pressure due to anti-viral drugs, human population genetics could be a possible reason for evolution of the virus.
PMID 33374416
Title Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation
Author(s) nameHuang SW, Miller SO, Yen CH, Wang SF.
Journal Genes (Basel)
Impact factor3.759
Citation count1
Date of publishing2020 Dec 24
Formation of three clusters with varying degree of fatality rates were reported: Cluster 1(3.0%) , Cluster 2 (9.3%), Cluster 3 (5.8%). Highest mortality rate was associated with Cluster 2. Susceptibility to COVID-19 infections is influenced not only by SARS-CoV-2 mutations but also by BCG vaccination status and HLA genotype.
PMID 32699345
Title SARS-CoV-2 genomic variations associated with mortality rate of COVID-19
Author(s) nameToyoshima Y, Nemoto K, Matsumoto S, Nakamura Y, Kiyotani K.
Journal J Hum Genet
Impact factor2.942
Citation count13
Date of publishing2020 Dec
A novel SARS-CoV-2 variant called the Y839 variant was reported in Portugal, which rapidly spread throughout the country by the end of April. This novel variant was imported from Italy and was more prevalent in the northern (22%) and central regions (59%) of Portugal.
PMID 33131453
Title Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal.
Author(s) nameBorges V, Isidro J, Cortes-Martins H, Duarte S, Vieira L, Leite R, Gordo I, Caetano CP, Nunes B, Sá R, Oliveira A, Guiomar R; Portuguese network for SARS-CoV-2 genomics, Gomes JP.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count1
Date of publishing2020 Dec