Pathophysiology


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A comparative cohort study was conducted on COVID 19 samples from two different variants Daxing B.1.1.7 and Shunyi B.1.470, to determine the clinical freatures of B.1.1.7 variant.
PMID -
Title COVID-19 cases from the first local outbreak of SARS-CoV-2 B.1.1.7 variant in China presented more serious clinical features: a prospective, comparative cohort study
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Date of publishing2021 May 08
Pseudovirus with L452R mutation showed higher infectivity in 293T cells (6.7- to 22.5-fold increase) and HAO cell line (5.8- to 14.7-fold increase) than D614G-Pseudovirus but slightly lower infectivity than N501Y-Pseudovirus.
PMID 33991487
Title Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant
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N440K variant of SARS CoV2, one of the prevalent strains found in India during the second wave of pandemic, produced 10 times and 1000 fold higher infectious viral titers than A2a (prevalent) and A3i (less prevalent) strains respectively. The results were obtained when Caco2 and Calu-3 cell cultures were infected with 0.1 MOI of the three variants and supernatant was collected after 24, 48 and 72 hpi.
PMID -
Title N440K variant of SARS-CoV-2 has Higher Infectious Fitness
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