Mutational escape


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Key Findings
Cocktails of antibodies targeting distinct non-overlapping regions of RBD significantly reduces escape mutations as compared to both single antibody treatment as well as treatment with a combination of antibodies targeting overlapping regions of RBD.
PMID 32540904
Title Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
Author(s) nameBaum A, Fulton BO, Wloga E, Copin R, Pascal KE, Russo V, Giordano S, Lanza K, Negron N, Ni M, Wei Y, Atwal GS, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA.
Journal Science
Impact factor20.57
Citation count110
Date of publishing2020 Aug 21