Viral protein-human protein


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Key Findings
Surface plasmon resonance (SPR) was used to compare the kinetics of SARS-CoV-2 S protein both D614 and D614G binding to human ACE2. D614G decreases the affinity for ACE2 by increasing the rate of dissociation.
PMID 32991842
Title Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
Author(s) nameYurkovetskiy L, Wang X, Pascal KE, Tomkins-Tinch C, Nyalile TP, Wang Y, Baum A, Diehl WE, Dauphin A, Carbone C, Veinotte K, Egri SB, Schaffner SF, Lemieux JE, Munro JB, Rafique A, Barve A, Sabeti PC, Kyratsous CA, Dudkina NV, Shen K, Luban J.
Journal Cell
Impact factor27.35
Citation count52
Date of publishing2020 Oct 29
Molecular interaction of SARS-CoV-2 N501Y mutant spike protein ectodomain bound to human ACE2 ectodomain and Fab ab1 and VH ab8
PMID 33914735
Title Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies
Author(s) nameZhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S.
Journal PLoS Biol
Impact factor7.62
Citation count
Date of publishing2021 Apr 29
Molecular docking study to determine the potential binding interfaces of SARS-CoV-2 ORF7a with leukocyte marker - LFA-1 (lymphocyte function-associated antigen) and Mac-1 ( Macrophage-1 antigen )
PMID 33305306
Title Structural assessment of SARS-CoV2 accessory protein ORF7a predicts LFA-1 and Mac-1 binding potential
Author(s) nameNizamudeen ZA, Xu ER, Karthik V, Halawa M, Arkill KP, Jackson AM, Bates DO, Emsley J.
Journal Biosci Rep
Impact factor2.51
Citation count1
Date of publishing2020 Dec 11
Reporting strong interaction between S2 subunit of SARS-nCoV-2 with tumor suppressor protein p53
PMID 32619819
Title S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study
Author(s) nameSingh N, Bharara Singh A.
Journal Transl Oncol
Impact factor3.3
Citation count4
Date of publishing2020 Oct
Reporting strong interaction between S2 subunit of SARS-nCoV-2 with tumor suppressor protein BRCA-1
PMID 32619819
Title S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study
Author(s) nameSingh N, Bharara Singh A.
Journal Transl Oncol
Impact factor3.3
Citation count4
Date of publishing2020 Oct
Reporting strong interaction between S2 subunit of SARS-nCoV-2 with tumor suppressor protein BRCA-2
PMID 32619819
Title S2 Subunit of SARS-nCoV-2 Interacts with Tumor Suppressor Protein p53 and BRCA: an In Silico Study
Author(s) nameSingh N, Bharara Singh A.
Journal Transl Oncol
Impact factor3.3
Citation count4
Date of publishing2020 Oct
Molecular interactions of SARS-CoV-2 S protein's RBD with ACE2 receptor and CR3022.
PMID 32245784
Title A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Author(s) nameYuan M, Wu NC, Zhu X, Lee CD, So RTY, Lv H, Mok CKP, Wilson IA.
Journal Science
Impact factor20.57
Citation count269
Date of publishing2020 May 8
Characterization of binding between SARS-CoV-2 and hACE2 and comparative studies of the SARS-CoV-2-CTD/hACE2 and SARS-RBD/hACE2 binding sites.
PMID 32275855
Title Structural and functional basis of SARS-CoV-2 entry by using human ACE2.
Author(s) nameWang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY, Wang Q, Zhou H, Yan J, Qi J.
Journal Cell
Impact factor27.35
Citation count447
Date of publishing2020 May 14
Proving that interaction between SARS-CoV-2-CTD and hACE2 Is specific and displays 4-fold stronger affinity compared with the SARS-RBD by real-time surface plasmon resonance (SPR) assays.
PMID 32275855
Title Structural and functional basis of SARS-CoV-2 entry by using human ACE2
Author(s) nameWang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY, Wang Q, Zhou H, Yan J, Qi J.
Journal Cell
Impact factor27.35
Citation count447
Date of publishing2020 May 14
The critical human ACE2-binding residues of SARS-CoV-2 RBD are L(455), GVEG (482-485), F (486), Q (493), S (494), N (501)
PMID 32225175
Title Structural basis of receptor recognition by SARS-CoV-2
Author(s) nameShang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F.
Journal Nature
Impact factor24.36
Citation count599
Date of publishing2020 May
Structural characterisation of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2
PMID 32225175
Title Structural basis of receptor recognition by SARS-CoV-2
Author(s) nameShang J, Ye G, Shi K, Wan Y, Luo C, Aihara H, Geng Q, Auerbach A, Li F.
Journal Nature
Impact factor24.36
Citation count599
Date of publishing2020 May
Molecular interactions between gangliosides and the NTD of SARS-CoV-2 S protein.
PMID 32251731
Title Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection
Author(s) nameFantini J, Di Scala C, Chahinian H, Yahi N.
Journal Int J Antimicrob Agents
Impact factor4.6
Citation count118
Date of publishing2020 May
Structural characterization of the SARS-CoV-2 receptor-binding domain of Spike glycoprotein in complex with host Cell receptor ACE2
PMID 32225176
Title Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
Author(s) nameLan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L, Wang X.
Journal Nature
Impact factor24.36
Citation count685
Date of publishing2020 May
Comparative molecular interaction study of hACE2 and Spike glycoprotein of SARS-CoV and SARS-CoV-2.
PMID 32155444
Title Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
Author(s) nameWalls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D.
Journal Cell
Impact factor27.35
Citation count1310
Date of publishing2020 Apr 16
Structural characterization of SARS-CoV-2 RBD-ACE2-BAT1 complex in closed conformation
PMID 32132184
Title Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
Author(s) nameYan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q.
Journal Science
Impact factor20.57
Citation count957
Date of publishing2020 Mar 27
Molecular interaction and kinetics of 2019-nCoV S and angiotensin-converting enzyme 2 (ACE2)
PMID 32075877
Title Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Author(s) nameWrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS.
Journal Science
Impact factor20.57
Citation count1471
Date of publishing2020 Mar 13
The S protein of SARS-CoV-2 interacts with the host cell receptor protein ACE2 (angiotensin-converting enzyme II), and thus enters the cell through an ACE2 receptor similar to SARS-CoV.
PMID 32015507
Title A pneumonia outbreak associated with a new coronavirus of probable bat origin
Author(s) nameZhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL.
Journal Nature
Impact factor24.36
Citation count3984
Date of publishing2020 Mar
A computational model of the potential molecular interactions between COVID-19 spike protein and human CD26 by selective docking.
PMID 32178593
Title Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26
Author(s) nameVankadari N, Wilce JA.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count130
Date of publishing2020