Vaccine


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Mice immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
Olive baboons immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
A multi-epitope vaccine was designed based on reverse-vaccinology approach. This vaccine was able to elicit a 'humoral' and 'cellular' immune response against SARS-CoV-2 infection.
PMID 33264668
Title Scrutinizing the SARS-CoV-2 protein information for designing an effective vaccine encompassing both the T-cell and B-cell epitopes
Author(s) nameJain N, Shankar U, Majee P, Kumar A.
Journal Infect Genet Evol
Impact factor2.67
Citation count1
Date of publishing2020 Nov 29