Serology


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In-vitro neutralization assays revealed that Israeli strain containing the P681H mutation was not associated with higher infection rates and got neutralized by sera from vaccinated individuals.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) nameNeta S. Zuckerman, Shay Fleishon, Efrat Bucris, Dana Bar-Ilan, Michal Linial, Itay Bar-Or, Victoria Indenbaum, Merav Weil, Ella Mendelson, Michal Mandelboim, Orna Mor
Journal
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Date of publishing2021 Mar 25
This study reports that one-third of the outpatients in Nicaragua had an acute mild COVID-19 infection and these patients were found to be seropositive for up to six months.
PMID
Title Antibody response to SARS-CoV-2 infection over six months among Nicaraguan 2 outpatients
Author(s) name-
Journal
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Date of publishing-
In a serology study, SARS-CoV-2 binding IgG and neutralising antibodies were detectable for up to one year in PCR-confirmed SARS-CoV-2 positive participants. The magnitude and durability of neutralising antibodies correlated positively with disease severity.
PMID
Title SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity
Author(s) name-
Journal
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In a small number of COVID-19 patients with mild disease, most of them showed antibodies against SECD, S1, RBD, and N for each isotype. The healthy individuals did not show these antibodies.
PMID 33450669
Title Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan
Author(s) nameTakeshita M, Nishina N, Moriyama S, Takahashi Y, Uwamino Y, Nagata M, Aoki W, Masaki K, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T; Keio Donner project.
Journal Virology
Impact factor2.819
Citation count1
Date of publishing2021 Jan 6
In a serology study, the presence of IgG and IgM antibody response in symptomatic and asymptomatic patients was assessed. The results showed that within 7 days at least 35% of the candidates showed seroconversion and within 45 days of symptoms onset, 95% showed simultaneous or sequential detection of IgM and IgG.
PMID 33444413
Title Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
Author(s) nameOjeda DS, Gonzalez Lopez Ledesma MM, Pallarés HM, Costa Navarro GS, Sanchez L, Perazzi B, Villordo SM, Alvarez DE; BioBanco Working Group, Echavarria M, Oguntuyo KY, Stevens CS, Lee B, Carradori J, Caramelo JJ, Yanovsky MJ, Gamarnik AV.
Journal PLoS Pathog
Impact factor6.18
Citation count1
Date of publishing2021 Jan
A considerable heterogeneity of IgM kinetics was observed in a longitudinal study of antibody response in COVID-19 patients.
PMID 33444413
Title Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
Author(s) nameOjeda DS, Gonzalez Lopez Ledesma MM, Pallarés HM, Costa Navarro GS, Sanchez L, Perazzi B, Villordo SM, Alvarez DE; BioBanco Working Group, Echavarria M, Oguntuyo KY, Stevens CS, Lee B, Carradori J, Caramelo JJ, Yanovsky MJ, Gamarnik AV.
Journal PLoS Pathog
Impact factor6.18
Citation count1
Date of publishing2021 Jan
A SARS-CoV-2 serology study conducted in a group of healthcare workers including nurses and non-patient-facing administrators showed a seropositivity prevalence of 4.8%.
PMID 33447642
Title Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago
Author(s) nameWilkins JT, Gray EL, Wallia A, Hirschhorn LR, Zembower TR, Ho J, Kalume N, Agbo O, Zhu A, Rasmussen-Torvik LJ, Khan SS, Carnethon M, Huffman M, Evans CT.
Journal Open Forum Infect Dis
Impact factor2.69
Citation count1
Date of publishing2021 Jan
In a small group of 29 people who had recovered from COVID-19, persistent antibody response against SARS-CoV-2 was observed upto 6 months after infection.
PMID 33315138
Title 6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort
Author(s) nameDeisenhammer F, Borena W, Bauer A, Kimpel J, Rudzki D, Schanda K, Egeter J, Hüfner K, Sperner-Unterweger B, Reindl M.
Journal Wien Klin Wochenschr
Impact factor1.15
Citation count1
Date of publishing2020 Dec 9
The presence of anti-SARS-CoV-2 antibodies in a small number of symptomatic and asymptomatic Tyrolian cohort was assessed.
PMID 33315138
Title 6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort
Author(s) nameDeisenhammer F, Borena W, Bauer A, Kimpel J, Rudzki D, Schanda K, Egeter J, Hüfner K, Sperner-Unterweger B, Reindl M.
Journal Wien Klin Wochenschr
Impact factor1.15
Citation count1
Date of publishing2020 Dec 9
This serosurveillance research on 3296 industrial workers showed that 7.37% of people had SARS-C0V-2 IgG. A rapid decline in the protective IgG antibodies was observed 45-65 days after the initial test.
PMID 33282604
Title A Prospective Study on Rapidly Declining SARS-CoV-2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?
Author(s) nameNag DS, Chaudhry R, Mishra M, Rai S, Gupta M.
Journal Cureus
Impact factorCant find
Citation count1
Date of publishing2020 Dec 2
The presence of anti-SARS-CoV-2 IgG antibody response in pregnant women was studied. The seroprevalence at the time of delivery is low.
PMID 33310133
Title SARS-COV-2 IgG antibody response in pregnant women at delivery
Author(s) nameTsatsaris V, Mariaggi AA, Launay O, Couffignal C, Rousseau J, Ancel PY, Marcault E, Ville Y, Cordier AG, Vivanti A, Carrara J, Luton D, Dommergues M, Borie C, Kayem G, Alessandrini V, Lecomte L, Meritet JF, Leruez-Ville M, Goffinet F, Dubois C, Picone O, Vauloup Fellous C.
Journal J Gynecol Obstet Hum Reprod
Impact factor
Citation count1
Date of publishing2020 Dec 10
Patients who had recovered showed increased anti-S IgG/IgM and high positive rates when compared to in-patients.
PMID 33310028
Title Dynamic Anti-Spike Protein Antibody Profiles in COVID-19 Patients
Author(s) nameBao Y, Ling Y, Chen YY, Tian D, Zhao GP, Zhang XH, Hang H, Li Y, Su B, Lu HZ, Xu J, Wang Y.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 10
Blood samples from a laboratory collected between January 2020 to April 2020 showed the presence of anti-SARS-CoV-2 antibodies in patients undergoing routine laboratory tests.
PMID 33271171
Title SARS-CoV-2 has been circulating in northeastern Brazil since February 2020: evidence for antibody detection in asymptomatic patients
Author(s) nameGurgel RQ, de Sá LC, Souza DRV, Martins AF, Matos ILS, Lima AGA, Vieira SCF, Neto JMR, Cuevas LE, Borges LP.
Journal J Infect
Impact factor5.1
Citation count1
Date of publishing2020 Dec 1
The kinetics of nucleocapsid and spike specific IgM and IgG responses in ICU and non-ICU COVID-19 patients were studied.
PMID 32357808
Title Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients
Author(s) nameSun B, Feng Y, Mo X, Zheng P, Wang Q, Li P, Peng P, Liu X, Chen Z, Huang H, Zhang F, Luo W, Niu X, Hu P, Wang L, Peng H, Huang Z, Feng L, Li F, Zhang F, Li F, Zhong N, Chen L.
Journal Emerg Microbes Infect
Impact factor5.84
Citation count70
Date of publishing2020 Dec
Serological responses to the RBD of SARS-CoV-2 in individuals infected with mild symptoms had significantly low titres in all three antibody isotypes.
PMID 33031941
Title Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh
Author(s) nameShirin T, Bhuiyan TR, Charles RC, Amin S, Bhuiyan I, Kawser Z, Rahat A, Alam AN, Sultana S, Aleem MA, Khan MH, Khan SR, LaRocque RC, Calderwood SB, Ryan ET, Slater DM, Banu S, Clemens J, Harris JB, Flora MS, Qadri F.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec
Anti-SARS-CoV-2 IgA levels in the tears of infected patients were studied.
PMID 33153065
Title Anti-SARS-Cov-2 IgA Response in Tears of COVID-19 Patients
Author(s) nameCaselli E, Soffritti I, Lamberti G, D'Accolti M, Franco F, Demaria D, Contoli M, Passaro A, Contini C, Perri P.
Journal Biology (Basel)
Impact factor3.05
Citation count1
Date of publishing2020 Nov 3
Seroconversion rate for Ab, IgM and IgG in COVID-19 patients was 93.1%, 82.7% and 64.7%, respectively.
PMID 32221519
Title Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019
Author(s) nameZhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, Wang X, Yuan J, Li T, Li J, Qian S, Hong C, Wang F, Liu Y, Wang Z, He Q, Li Z, He B, Zhang T, Fu Y, Ge S, Liu L, Zhang J, Xia N, Zhang Z.
Journal Clin Infect Dis
Impact factor7.71
Citation count530
Date of publishing2020 Nov 19
Seroconversion patterns of IgG and IgM antibodies(nucleocapsid (N) protein and spike (S) glycoprotein) in patients infected with SARS-CoV-2 show that the seroconversion time of the IgG antibody was earlier than that of IgM antibody.
PMID 32337590
Title Profile of Immunoglobulin G and IgM Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Author(s) nameQu J, Wu C, Li X, Zhang G, Jiang Z, Li X, Zhu Q, Liu L.
Journal Clin Infect Dis
Impact factor7.71
Citation count56
Date of publishing2020 Nov 19
Out of 1122 participants in an Indian Tertiary care hospital, overall seroprevalence for SARS-CoV-2 IgG antibodies was 11.94%.
PMID 33187030
Title Seroprevalence of COVID-19 amongst Health care workers in a Tertiary Care Hospital of a Metropolitan City from India
Author(s) nameGoenka M, Afzalpurkar S, Goenka U, Das SS, Mukherjee M, Jajodia S, Shah BB, Patil VU, Rodge G, Khan U, Bandyopadhyay S.
Journal J Assoc Physicians India
Impact factor
Citation count2
Date of publishing2020 Nov
Studying the kinetics and antibody isotype profile to the RBD of S protein in individuals with severe infection was done along with cross-reactivity of the responses with different coronaviruses RBDs. Characterization of assay performance using the dried blood spots was done which can provide an alternative to serum or plasma.
PMID 33033172
Title Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients.
Author(s) nameIyer AS, Jones FK, Nodoushani A, Kelly M, Becker M, Slater D, Mills R, Teng E, Kamruzzaman M, Garcia-Beltran WF, Astudillo M, Yang D, Miller TE, Oliver E, Fischinger S, Atyeo C, Iafrate AJ, Calderwood SB, Lauer SA, Yu J, Li Z, Feldman J, Hauser BM, Caradonna TM, Branda JA, Turbett SE, LaRocque RC, Mellon G, Barouch DH, Schmidt AG, Azman AS, Alter G, Ryan ET, Harris JB, Charles RC.
Journal Sci Immunol
Impact factor8.16
Citation count26
Date of publishing2020 Oct 8
Among 61437 community members in the study, 1470 individuals tested positive for at least one SARS-CoV-2 IgG or IgM antibody. Overall seropositivity rate was 2.39%.
PMID 33035672
Title Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign
Author(s) namePan Y, Li X, Yang G, Fan J, Tang Y, Hong X, Guo S, Li J, Yao D, Cheng Z, Yuan Y, Li Y, Wang X.
Journal Clin Microbiol Infect
Impact factor6.17
Citation count3
Date of publishing2020 Oct 6
Sera from hamsters infected with the WT SARS-CoV-2 (D614) virus showed higher neutralization against the G614 virus than against the D614 virus.
PMID 33106671
Title Spike mutation D614G alters SARS-CoV-2 fitness
Author(s) namePlante JA, Liu Y, Liu J, Xia H, Johnson BA, Lokugamage KG, Zhang X, Muruato AE, Zou J, Fontes-Garfias CR, Mirchandani D, Scharton D, Bilello JP, Ku Z, An Z, Kalveram B, Freiberg AN, Menachery VD, Xie X, Plante KS, Weaver SC, Shi PY.
Journal Nature
Impact factor24.36
Citation count38
Date of publishing2020 Oct 26
Asymptomatic patients produced fewer antibodies than symptomatic patients as the patients that had viral RNA shedding after IgG detection was more likely to be ill.
PMID 33085103
Title Clinical features and antibody response of patients from a COVID-19 treatment hospital in Wuhan, China
Author(s) nameChen Y, Ke Y, Liu X, Wang Z, Jia R, Liu W, Yang C, Jia L, Wang Y, Han L, Xia X, Zhang S, Wang C.
Journal J Med Virol
Impact factor2.07
Citation count1
Date of publishing2020 Oct 21
Substantial differences in the anti-glycan antibodies in infected patients and the importance of including host and viral carbohydrate antigens when studying immune responses to viruses were identified. This detection of antibodies helps in using the convalescent serum to treat patients and also produce an effective vaccine by understanding the risk of the infection.
PMID 33083799
Title Abnormal antibodies to self-carbohydrates in SARS-CoV-2 infected patients
Author(s) nameButler DL, Gildersleeve JC.
Journal bioRxiv
Impact factorIts not a journal
Citation count1
Date of publishing2020 Oct 16
The clinical characteristics,RT-PCR results from throat swab specimens, and the results of serological COVID-19 rapid diagnostic test (RDT) for SARS-CoV-2 on review in patients who had recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, hinting at the possibility of transmission of the virus even by recovered patients.
PMID 33050892
Title Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study
Author(s) nameShui TJ, Li C, Liu HB, Chen X, Zhang BK.
Journal BMC Infect Dis
Impact factor2.58
Citation count2
Date of publishing2020 Oct 13