Immunology


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Analysis of the peripheral lymphocyte subsets in Covid-19 patients showed a decrease in the number of T cells (helper T (Th) cells, suppressor T cells and regulatory T cells). A significant increase in the levels of infection-related biomarkers and inflammatory cytokines was observed in patients with the severe form of the disease.
PMID 32161940
Title Dysregulation of immune response in patients with COVID-19 in Wuhan, China
Author(s) nameQin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS.
Journal Clin Infect Dis
Impact factor7.71
Citation count897
Date of publishing2020 Jul 28
In-vitro neutralization assays revealed that Israeli strain containing the P681H mutation was not associated with higher infection rates and got neutralized by sera from vaccinated individuals.
PMID
Title A unique SARS-CoV-2 spike protein P681H strain detected in Israel
Author(s) nameNeta S. Zuckerman, Shay Fleishon, Efrat Bucris, Dana Bar-Ilan, Michal Linial, Itay Bar-Or, Victoria Indenbaum, Merav Weil, Ella Mendelson, Michal Mandelboim, Orna Mor
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Date of publishing2021 Mar 25
In a serology study, SARS-CoV-2 binding IgG and neutralising antibodies were detectable for up to one year in PCR-confirmed SARS-CoV-2 positive participants. The magnitude and durability of neutralising antibodies correlated positively with disease severity.
PMID
Title SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity
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This study reports that one-third of the outpatients in Nicaragua had an acute mild COVID-19 infection and these patients were found to be seropositive for up to six months.
PMID
Title Antibody response to SARS-CoV-2 infection over six months among Nicaraguan 2 outpatients
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The T cell distribution in non-seroconverters (NSC) showed high levels of CD4+ naive T cells and low levels of T transitional memory and CD8+ T effector cells. No significant difference was observed in the levels of N and SP specific CD+ T cells between the non-seroconverters and seroconverters. On antigen stimulation, the CD4+ and CD8+ T cells from non-seroconverters showed decreased PD-1 levels when compared to seroconverters.
PMID -
Title Highly functional Cellular Immunity in SARS-CoV-2 Non-Seroconvertors is associated with immune protection
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Date of publishing2021 May 04
T cells play an important role in viral clearance when compared to antibodies in patients with mild COVID-19 (88.8%). Anti-inflammatory responses such as cytokine inhibition rate and tissue repair rate are correlated to T cell number and these are suppressed in non-survivors.
PMID -
Title Impairment of T cells antiviral and anti-inflammation immunities dominates the death from COVID-19
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Date of publishing2021 Apr 29
Deletions at positions 144/145 and 243-244 in the NTD region of S glycoprotein disrupt the binding of antibody 4A8, which defines an immunodominant epitope within the NTD.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
In a small number of COVID-19 patients with mild disease, most of them showed antibodies against SECD, S1, RBD, and N for each isotype. The healthy individuals did not show these antibodies.
PMID 33450669
Title Incomplete humoral response including neutralizing antibodies in asymptomatic to mild COVID-19 patients in Japan
Author(s) nameTakeshita M, Nishina N, Moriyama S, Takahashi Y, Uwamino Y, Nagata M, Aoki W, Masaki K, Ishii M, Saya H, Kondo Y, Kaneko Y, Suzuki K, Fukunaga K, Takeuchi T; Keio Donner project.
Journal Virology
Impact factor2.819
Citation count1
Date of publishing2021 Jan 6
Mice immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
Olive baboons immunized with adjuvanted NVX-CoV2373 vaccine had significantly higher anti-S IgG antibody titers. The antibodies showed good neutralizing activity and blocked the binding of the virus to the hACE-2 receptor.
PMID 33446655
Title SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
Author(s) nameTian JH, Patel N, Haupt R, Zhou H, Weston S, Hammond H, Logue J, Portnoff AD, Norton J, Guebre-Xabier M, Zhou B, Jacobson K, Maciejewski S, Khatoon R, Wisniewska M, Moffitt W, Kluepfel-Stahl S, Ekechukwu B, Papin J, Boddapati S, Jason Wong C, Piedra PA, Frieman MB, Massare MJ, Fries L, Bengtsson KL, Stertman L, Ellingsworth L, Glenn G, Smith G.
Journal Nat Commun
Impact factor11.8
Citation count5
Date of publishing2021 Jan 14
In a serology study, the presence of IgG and IgM antibody response in symptomatic and asymptomatic patients was assessed. The results showed that within 7 days at least 35% of the candidates showed seroconversion and within 45 days of symptoms onset, 95% showed simultaneous or sequential detection of IgM and IgG.
PMID 33444413
Title Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
Author(s) nameOjeda DS, Gonzalez Lopez Ledesma MM, Pallarés HM, Costa Navarro GS, Sanchez L, Perazzi B, Villordo SM, Alvarez DE; BioBanco Working Group, Echavarria M, Oguntuyo KY, Stevens CS, Lee B, Carradori J, Caramelo JJ, Yanovsky MJ, Gamarnik AV.
Journal PLoS Pathog
Impact factor6.18
Citation count1
Date of publishing2021 Jan
Statistical comparisons of the 3 clinical case subjects reveal an increase of SERPING1, the transcript encoding C1 esterase inhibitor (C1–INH). C1-INH plays a central role in the activation of the complement system and is potentially linked to complement hyperactivation in COVID-19.
PMID 33437888
Title Clinically distinct COVID-19 cases share notably similar immune response progression: A follow-up analysis
Author(s) nameHausburg MA, Banton KL, Roshon M, Bar-Or D.
Journal Heliyon
Impact factor1.65
Citation count1
Date of publishing2021 Jan
A considerable heterogeneity of IgM kinetics was observed in a longitudinal study of antibody response in COVID-19 patients.
PMID 33444413
Title Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina
Author(s) nameOjeda DS, Gonzalez Lopez Ledesma MM, Pallarés HM, Costa Navarro GS, Sanchez L, Perazzi B, Villordo SM, Alvarez DE; BioBanco Working Group, Echavarria M, Oguntuyo KY, Stevens CS, Lee B, Carradori J, Caramelo JJ, Yanovsky MJ, Gamarnik AV.
Journal PLoS Pathog
Impact factor6.18
Citation count1
Date of publishing2021 Jan
A SARS-CoV-2 serology study conducted in a group of healthcare workers including nurses and non-patient-facing administrators showed a seropositivity prevalence of 4.8%.
PMID 33447642
Title Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago
Author(s) nameWilkins JT, Gray EL, Wallia A, Hirschhorn LR, Zembower TR, Ho J, Kalume N, Agbo O, Zhu A, Rasmussen-Torvik LJ, Khan SS, Carnethon M, Huffman M, Evans CT.
Journal Open Forum Infect Dis
Impact factor2.69
Citation count1
Date of publishing2021 Jan
In a small group of 29 people who had recovered from COVID-19, persistent antibody response against SARS-CoV-2 was observed upto 6 months after infection.
PMID 33315138
Title 6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort
Author(s) nameDeisenhammer F, Borena W, Bauer A, Kimpel J, Rudzki D, Schanda K, Egeter J, Hüfner K, Sperner-Unterweger B, Reindl M.
Journal Wien Klin Wochenschr
Impact factor1.15
Citation count1
Date of publishing2020 Dec 9
The presence of anti-SARS-CoV-2 antibodies in a small number of symptomatic and asymptomatic Tyrolian cohort was assessed.
PMID 33315138
Title 6-month SARS-CoV-2 antibody persistency in a Tyrolian COVID-19 cohort
Author(s) nameDeisenhammer F, Borena W, Bauer A, Kimpel J, Rudzki D, Schanda K, Egeter J, Hüfner K, Sperner-Unterweger B, Reindl M.
Journal Wien Klin Wochenschr
Impact factor1.15
Citation count1
Date of publishing2020 Dec 9
9 T-cell epitopes that have potential to be vaccine candidates were identified. These were cross-checked with experimentally verified epitopes of various organisms inclusive of SARS-CoV. These peptides require in-vitro and in-vivo experimental validation.
PMID 33285567
Title Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach
Author(s) nameAlam A, Khan A, Imam N, Siddiqui MF, Waseem M, Malik MZ, Ishrat R.
Journal Brief Bioinform
Impact factor5.45
Citation count3
Date of publishing2020 Dec 8
6 potent B-cell epitope were identified and verified with experimental epitopes of various organisms inclusive of SARS-CoV. These peptides require in-vitro and in-vivo experimental validation.
PMID 33285567
Title Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach
Author(s) nameAlam A, Khan A, Imam N, Siddiqui MF, Waseem M, Malik MZ, Ishrat R.
Journal Brief Bioinform
Impact factor5.45
Citation count3
Date of publishing2020 Dec 8
Using an evolutionary protein design algorithm, EvoDesign, thousands of stable S protein variants which keep the surface conformation and B cell epitopes intact were studied. The T cell epitope content and similarity score were then calculated. The newly designed S protein introduced 9 new MHC-II T cell epitopes that do not exist in the wildtype SARS-CoV-2.
PMID 33398234
Title Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
Author(s) nameOng E, Huang X, Pearce R, Zhang Y, He Y.
Journal Comput Struct Biotechnol J
Impact factor5.11
Citation count1
Date of publishing2020 Dec 31
Mice immunized with liposomal peptides elicited a significantly high number of IFN-g-producing CD8+T cells
PMID 33268522
Title Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8 + T cell recognition in vivo
Author(s) nameTakagi A, Matsui M.
Journal J Virol
Impact factor4.16
Citation count1
Date of publishing2020 Dec 2
This serosurveillance research on 3296 industrial workers showed that 7.37% of people had SARS-C0V-2 IgG. A rapid decline in the protective IgG antibodies was observed 45-65 days after the initial test.
PMID 33282604
Title A Prospective Study on Rapidly Declining SARS-CoV-2 IgG Antibodies Within One to Three Months of Testing IgG Positive: Can It Lead to Potential Reinfections?
Author(s) nameNag DS, Chaudhry R, Mishra M, Rai S, Gupta M.
Journal Cureus
Impact factorCant find
Citation count1
Date of publishing2020 Dec 2
In convalescent patients that heal quickly from COVID-19 have different CD4 + T cell subsets that persist well past the disease resolution.
PMID 33171099
Title Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
Author(s) nameChen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR.
Journal Cell
Impact factor27.35
Citation count8
Date of publishing2020 Dec 10
The increased somatic hypermutation (SHM) in virus-specific memory B cells early after recovery is a unique feature observed in sustainers (convalescent patients showing stable or enhanced antibody production several months after infection).
PMID 33171099
Title Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production
Author(s) nameChen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR.
Journal Cell
Impact factor27.35
Citation count8
Date of publishing2020 Dec 10
Patients who had recovered showed increased anti-S IgG/IgM and high positive rates when compared to in-patients.
PMID 33310028
Title Dynamic Anti-Spike Protein Antibody Profiles in COVID-19 Patients
Author(s) nameBao Y, Ling Y, Chen YY, Tian D, Zhao GP, Zhang XH, Hang H, Li Y, Su B, Lu HZ, Xu J, Wang Y.
Journal Int J Infect Dis
Impact factor3.42
Citation count1
Date of publishing2020 Dec 10
The presence of anti-SARS-CoV-2 IgG antibody response in pregnant women was studied. The seroprevalence at the time of delivery is low.
PMID 33310133
Title SARS-COV-2 IgG antibody response in pregnant women at delivery
Author(s) nameTsatsaris V, Mariaggi AA, Launay O, Couffignal C, Rousseau J, Ancel PY, Marcault E, Ville Y, Cordier AG, Vivanti A, Carrara J, Luton D, Dommergues M, Borie C, Kayem G, Alessandrini V, Lecomte L, Meritet JF, Leruez-Ville M, Goffinet F, Dubois C, Picone O, Vauloup Fellous C.
Journal J Gynecol Obstet Hum Reprod
Impact factor
Citation count1
Date of publishing2020 Dec 10