Epitope


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Key Findings
Deletions at positions 144/145 and 243-244 in the NTD region of S glycoprotein disrupt the binding of antibody 4A8, which defines an immunodominant epitope within the NTD.
PMID 33536258
Title Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape
Author(s) nameMcCarthy KR, Rennick LJ, Nambulli S, Robinson-McCarthy LR, Bain WG, Haidar G, Duprex WP.
Journal Science
Impact factor20.57
Citation count6
Date of publishing2021 Feb 3
6 potent B-cell epitope were identified and verified with experimental epitopes of various organisms inclusive of SARS-CoV. These peptides require in-vitro and in-vivo experimental validation.
PMID 33285567
Title Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach
Author(s) nameAlam A, Khan A, Imam N, Siddiqui MF, Waseem M, Malik MZ, Ishrat R.
Journal Brief Bioinform
Impact factor5.45
Citation count3
Date of publishing2020 Dec 8
9 T-cell epitopes that have potential to be vaccine candidates were identified. These were cross-checked with experimentally verified epitopes of various organisms inclusive of SARS-CoV. These peptides require in-vitro and in-vivo experimental validation.
PMID 33285567
Title Design of an epitope-based peptide vaccine against the SARS-CoV-2: a vaccine-informatics approach
Author(s) nameAlam A, Khan A, Imam N, Siddiqui MF, Waseem M, Malik MZ, Ishrat R.
Journal Brief Bioinform
Impact factor5.45
Citation count3
Date of publishing2020 Dec 8
Using an evolutionary protein design algorithm, EvoDesign, thousands of stable S protein variants which keep the surface conformation and B cell epitopes intact were studied. The T cell epitope content and similarity score were then calculated. The newly designed S protein introduced 9 new MHC-II T cell epitopes that do not exist in the wildtype SARS-CoV-2.
PMID 33398234
Title Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering
Author(s) nameOng E, Huang X, Pearce R, Zhang Y, He Y.
Journal Comput Struct Biotechnol J
Impact factor5.11
Citation count1
Date of publishing2020 Dec 31
Mice immunized with liposomal peptides elicited a significantly high number of IFN-g-producing CD8+T cells
PMID 33268522
Title Identification of HLA-A*02:01-restricted candidate epitopes derived from the non-structural polyprotein 1a of SARS-CoV-2 that may be natural targets of CD8 + T cell recognition in vivo
Author(s) nameTakagi A, Matsui M.
Journal J Virol
Impact factor4.16
Citation count1
Date of publishing2020 Dec 2
34 cytotoxic T cell epitopes located in spike glycoprotein, envelope protein, membrane protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
14 helper T cell epitopes located in spike glycoprotein, envelope protein, and nucleocapsid phosphoprotein were identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
1 linear Bcell epitopes was identified.
PMID 33257716
Title Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2
Author(s) nameBehmard E, Soleymani B, Najafi A, Barzegari E.
Journal Sci Rep
Impact factor4.12
Citation count1
Date of publishing2020 Nov 30
A multi-epitope vaccine was designed based on reverse-vaccinology approach. This vaccine was able to induce a humoral and cellular immune response against SARS-CoV-2 infection.
PMID 33264668
Title Scrutinizing the SARS-CoV-2 protein information for designing an effective vaccine encompassing both the T-cell and B-cell epitopes
Author(s) nameJain N, Shankar U, Majee P, Kumar A.
Journal Infect Genet Evol
Impact factor2.67
Citation count1
Date of publishing2020 Nov 29
Selection and prediction of immunogenic epitopes were performed.
PMID 33072338
Title Development of a novel platform of virus-like particle (VLP) based vaccine against coronavirus 2019 (SARS-CoV-2) by exposing of epitopes: an immunoinformatics approach.
Author(s) nameGhorbani A, Zare F, Sazegari S, Afsharifar A, Eskandari MH, Pormohammad A.
Journal New Microbes New Infect
Impact factor1.6
Citation count1
Date of publishing2020 Nov
A list of highly probable epitopes that could help in developing a prophylactic and therapeutic epitope-based vaccine were identified.
PMID 33047062
Title Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2.
Author(s) nameMishra S.
Journal R Soc Open Sci
Impact factor2.68
Citation count2
Date of publishing2020 Sep
Assessment of T cell responses from convalescent individuals showed that the CD4 and CD8 T cells recognised a number of regions on the N protein.
PMID 32668444
Title SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls
Author(s) nameLe Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A, Chng MHY, Lin M, Tan N, Linster M, Chia WN, Chen MI, Wang LF, Ooi EE, Kalimuddin S, Tambyah PA, Low JG, Tan YJ, Bertoletti A.
Journal Nature
Impact factor24.36
Citation count119
Date of publishing2020 Aug
Four linear B-cell epitopes on the S and N viral proteins were identified.
PMID 32711254
Title Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity
Author(s) nameAmrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP.
Journal EBioMedicine
Impact factor6.49
Citation count9
Date of publishing2020 Aug
8 spike glycoprotein MHCII epitopes lying in the predetermined B-cell epitope region and their antigenicity were predicted.
PMID 32108359
Title Development of epitopebased peptide vaccine against novel coronavirus 2019 (SARSCOV2): Immunoinformatics approach
Author(s) nameBhattacharya M, Sharma AR, Patra P, Ghosh P, Sharma G, Patra BC, Lee SS, Chakraborty C.
Journal J Med Virol
Impact factor2.07
Citation count92
Date of publishing2020 Jun
29 spike glycoprotein MHCI epitopes lying in the predetermined B-cell epitope region and their antigenicity were predicted.
PMID 32108359
Title Development of epitopebased peptide vaccine against novel coronavirus 2019 (SARSCOV2): Immunoinformatics approach
Author(s) nameBhattacharya M, Sharma AR, Patra P, Ghosh P, Sharma G, Patra BC, Lee SS, Chakraborty C.
Journal J Med Virol
Impact factor2.07
Citation count92
Date of publishing2020 Jun
34 linear spike glycoprotein Bcell epitopes were identified.
PMID 32108359
Title Development of epitopebased peptide vaccine against novel coronavirus 2019 (SARSCOV2): Immunoinformatics approach
Author(s) nameBhattacharya M, Sharma AR, Patra P, Ghosh P, Sharma G, Patra BC, Lee SS, Chakraborty C.
Journal J Med Virol
Impact factor2.07
Citation count92
Date of publishing2020 Jun
Some of the immunogenic domains' conserved structure and mapping position were identified.
PMID 32446902
Title Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Babini G, De Maio F, Britti D, Zecconi A, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count19
Date of publishing2020 May-Jun
Epitopes of bat RaTG13 coronavirus and SARS-CoV showed 100% sequence identity with SARS-CoV-2 epitopes, whereas some pangolin NC protein epitopes showed a lower identity percentage.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
Three (conserved) epitopes from nucleocapsid protein of SARS-CoV-2 were identified by In-silico method.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
Two (conserved) epitopes from nucleocapsid protein of SARS-CoV-2 were identified by in silico method.
PMID 32302675
Title Comparative computational analysis of SARS-CoV-2 nucleocapsid protein epitopes in taxonomically related coronaviruses
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Musella V, Britti D, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count33
Date of publishing2020 May-Jun
Eight (conserved) epitopes from envelop protein of SARS-CoV-2 were identified by in silico method.
PMID 32446902
Title Immunoinformatic analysis of the SARS-CoV-2 envelope protein as a strategy to assess cross-protection against COVID-19
Author(s) nameTilocca B, Soggiu A, Sanguinetti M, Babini G, De Maio F, Britti D, Zecconi A, Bonizzi L, Urbani A, Roncada P.
Journal Microbes Infect
Impact factor2.373
Citation count19
Date of publishing2020 May-Jun
Five Linear B-cell epitopes in the spike protein of the Indian SARS-CoV-2 were identified, which can induce an immune response and suppress IFN- response.
PMID 32242873
Title Full-genome sequences of the first two SARS-CoV-2 viruses from India
Author(s) nameYadav PD, Potdar VA, Choudhary ML, Nyayanit DA, Agrawal M, Jadhav SM, Majumdar TD, Shete-Aich A, Basu A, Abraham P, Cherian SS.
Journal Indian J Med Res
Impact factor1.3
Citation count28
Date of publishing2020 Feb & Mar
Nine cytotoxic T cell epitopes in the spike protein of the Indian SARS-CoV-2 were identified, which can induce an IFN- response.
PMID 32242873
Title Full-genome sequences of the first two SARS-CoV-2 viruses from India
Author(s) nameYadav PD, Potdar VA, Choudhary ML, Nyayanit DA, Agrawal M, Jadhav SM, Majumdar TD, Shete-Aich A, Basu A, Abraham P, Cherian SS.
Journal Indian J Med Res
Impact factor1.3
Citation count28
Date of publishing2020 Feb & Mar
CD8 T cell epitopes of 80 different human HLAs were generated for SARS-CoV-2 Spike protein.
PMID 33301503
Title CD8 T cell epitope generation toward the continually mutating SARS-CoV-2 spike protein in genetically diverse human population: Implications for disease control and prevention
Author(s) nameGuo E, Guo H.
Journal PLoS One
Impact factor2.87
Citation count1
Date of publishing2020
Out of the many B-cell 'epitopes', SRVKNL ('envelope protein') could be a possible vaccine candidate as it enables direct interactions with immune receptor.
PMID 33299503
Title An Immunoinformatics Study to Predict Epitopes in the Envelope Protein of SARS-CoV-2
Author(s) nameJakhar R, Gakhar SK.
Journal Can J Infect Dis Med Microbiol
Impact factor1.41
Citation count1
Date of publishing2020