Antibody


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Key Findings
Neutralizing antibodies coupled on the photothermal nanoparticle helps in inactivation of virus by preventing the entry of virus into ACE-2 expressing host cell.
PMID 33269351
Title A Neutralizing Antibody-Conjugated Photothermal Nanoparticle Captures and Inactivates SARS-CoV-2
Author(s) nameCai X, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Chen M, Shi J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J.
Journal bioRxiv
Impact factorIts not a journal
Citation count4
Date of publishing2020 Nov 30
The neutralizing potential efficiency of anti-Spike-S1 IgYs (chicken egg yolk antibodies) that blocks the binding of various variants of SARS-CoV-2 spike protein to ACE-2 receptor was researched.
PMID 33191178
Title Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2
Author(s) nameWei S, Duan S, Liu X, Wang H, Ding S, Chen Y, Xie J, Tian J, Yu N, Ge P, Zhang X, Chen X, Li Y, Meng Q.
Journal Int Immunopharmacol
Impact factor3.38
Citation count1
Date of publishing2020 Nov 3
REGN-COV2 antibodies are efficacious when used prophylactically or therapeutically. This mAB cocktail could reduce the viral load and also decrease virus-induced pathological sequelae in rhesus macaque and limit weight loss in hamsters.
PMID 33037066
Title REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
Author(s) nameBaum A, Ajithdoss D, Copin R, Zhou A, Lanza K, Negron N, Ni M, Wei Y, Mohammadi K, Musser B, Atwal GS, Oyejide A, Goez-Gazi Y, Dutton J, Clemmons E, Staples HM, Bartley C, Klaffke B, Alfson K, Gazi M, Gonzalez O, Dick E Jr, Carrion R Jr, Pessaint L, Porto M, Cook A, Brown R, Ali V, Greenhouse J, Taylor T, Andersen H, Lewis MG, Stahl N, Murphy AJ, Yancopoulos GD, Kyratsous CA.
Journal Science
Impact factor20.57
Citation count29
Date of publishing2020 Nov 27
4A8 monoclonal antibody shows a high affinity to bind to the polybasic insert at the furin-like cleavage site.
PMID 33269352
Title A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
Author(s) nameCheng MH, Porritt RA, Rivas MN, Krieger JM, Ozdemir AB, Garcia G, Arumugaswami V, Fries BC, Arditi M, Bahar I.
Journal bioRxiv
Impact factorIts not a journal
Citation count2
Date of publishing2020 Nov 24
6D3 monoclonal antibody can block the SARS-CoV infection by inhibiting the access of host cell proteases, TMPRSS2 or furin.
PMID 33269352
Title A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
Author(s) nameCheng MH, Porritt RA, Rivas MN, Krieger JM, Ozdemir AB, Garcia G, Arumugaswami V, Fries BC, Arditi M, Bahar I.
Journal bioRxiv
Impact factorIts not a journal
Citation count2
Date of publishing2020 Nov 24
A monoclonal Antibody (2B04) potently inhibited SARS-CoV-2 infection with an IC50 of 3.007 ng/mL.
PMID 33035201
Title Neutralizing antibody against SARS-CoV-2 spike in COVID-19 patients, health care workers and convalescent plasma donors.
Author(s) nameZeng C, Evans JP, Pearson R, Qu P, Zheng YM, Robinson RT, Hall-Stoodley L, Yount J, Pannu S, Mallampalli RK, Saif L, Oltz E, Lozanski G, Liu SL.
Journal JCI Insight
Impact factor6.014
Citation count4
Date of publishing2020 Nov 19
Of the 35 monoclonal anti-bodies 'isolate', mAb 4A8 displayed high neutralizing activity against both the authentic and pseudotyped SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Of the 35 monoclonal anti-bodies isolate, mAb IM-ID2 displayed high neutralizing activity against live SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-3
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Of the 35 monoclonal anti-bodies 'isolate', mAb 0304-3H3 displayed high neutralizing activity against live SARS-CoV2.
PMID 32571838
Title A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-4
Author(s) nameChi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y, Chen Z, Guo Y, Zhang J, Li Y, Song X, Chen Y, Xia L, Fu L, Hou L, Xu J, Yu C, Li J, Zhou Q, Chen W.
Journal Science
Impact factor20.57
Citation count135
Date of publishing2020 Aug 7
Monoclonal antibody MD63 did not show neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD65 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD45 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD67 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD62 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD29 showed neutralizing activity in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
Monoclonal antibody MD17 showed a poor neutralizing activity (NT50) in the plaque reduction neutralization test (PRNT) using VeroE6 cells infected with the pathogenic SARS-CoV-2.
PMID 32855401
Title A panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes
Author(s) nameNoy-Porat T, Makdasi E, Alcalay R, Mechaly A, Levy Y, Bercovich-Kinori A, Zauberman A, Tamir H, Yahalom-Ronen Y, Israeli M, Epstein E, Achdout H, Melamed S, Chitlaru T, Weiss S, Peretz E, Rosen O, Paran N, Yitzhaki S, Shapira SC, Israely T, Mazor O, Rosenfeld R.
Journal Nat Commun
Impact factor11.8
Citation count7
Date of publishing2020 Aug 27
A mnoclonal antibody (CC12.1) neutralized SARS-CoV-2 in vitro and provided full protection against SARS-CoV-2 infection in Syrian hamsters at a serum concentration of ~22 μg/ml.
PMID 32540903
Title Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Author(s) nameRogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR.
Journal Science
Impact factor20.57
Citation count186
Date of publishing2020 Aug 21
A monoclonal antibody (CC12.23) neutralized SARS-CoV-2 in vitro and did not protect against SARS-CoV-2 infection in Syrian hamsters at any concentration.
PMID 32540903
Title Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
Author(s) nameRogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR.
Journal Science
Impact factor20.57
Citation count186
Date of publishing2020 Aug 21
The P2B-2F6 antibody was found to be the most potent in neutralization of pseudoviruses bearing SARS-CoV-2 spike protein or live SARS-CoV-2.
PMID 32454513
Title Human neutralizing antibodies elicited by SARS-CoV-2 infection
Author(s) nameJu B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L.
Journal Nature
Impact factor24.36
Citation count256
Date of publishing2020 Aug
The P2C-1F11 antibody was found to be the most potent in the neutralization of pseudoviruses bearing SARS-CoV-2 spike protein or live SARS-CoV-2.
PMID 32454513
Title Human neutralizing antibodies elicited by SARS-CoV-2 infection
Author(s) nameJu B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L.
Journal Nature
Impact factor24.36
Citation count256
Date of publishing2020 Aug
A monoclonal antibody (COV2-2381) protected rhesus macaques against SARS-CoV-2 infection.
PMID 32668443
Title Potently neutralizing and protective human antibodies against SARS-CoV-2
Author(s) nameZost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr.
Journal Nature
Impact factor24.36
Citation count97
Date of publishing2020 Aug
A monoclonal antibody (mAb) (COV2-2130) protected mice from SARS-CoV-2 infection. A combination of this mAb and COV2-2196 also protected mice from SARS-CoV-2 infection.
PMID 32668443
Title Potently neutralizing and protective human antibodies against SARS-CoV-2
Author(s) nameZost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr.
Journal Nature
Impact factor24.36
Citation count97
Date of publishing2020 Aug
A monoclonal antibody (COV2-2196) protected mice and rhesus macaques from SARS-CoV-2 infection. A combination of this monoclonal antibody and COV2-2130 also protected mice from SARS-CoV-2 infection.
PMID 32668443
Title Potently neutralizing and protective human antibodies against SARS-CoV-2
Author(s) nameZost SJ, Gilchuk P, Case JB, Binshtein E, Chen RE, Nkolola JP, Schäfer A, Reidy JX, Trivette A, Nargi RS, Sutton RE, Suryadevara N, Martinez DR, Williamson LE, Chen EC, Jones T, Day S, Myers L, Hassan AO, Kafai NM, Winkler ES, Fox JM, Shrihari S, Mueller BK, Meiler J, Chandrashekar A, Mercado NB, Steinhardt JJ, Ren K, Loo YM, Kallewaard NL, McCune BT, Keeler SP, Holtzman MJ, Barouch DH, Gralinski LE, Baric RS, Thackray LB, Diamond MS, Carnahan RH, Crowe JE Jr.
Journal Nature
Impact factor24.36
Citation count97
Date of publishing2020 Aug
The P2C-1A3 antibody was found to be the most potent in neutralization of pseudoviruses bearing SARS-CoV-2 spike protein or live SARS-CoV-2.
PMID 32454513
Title Human neutralizing antibodies elicited by SARS-CoV-2 infection
Author(s) nameJu B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X, Zhang Z, Zhang L.
Journal Nature
Impact factor24.36
Citation count256
Date of publishing2020 Aug
A monoclonal antibody (553-60) neutralized SARS-CoV-2 infection in vitro.
PMID 32668215
Title Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection
Author(s) nameWan J, Xing S, Ding L, Wang Y, Gu C, Wu Y, Rong B, Li C, Wang S, Chen K, He C, Zhu D, Yuan S, Qiu C, Zhao C, Nie L, Gao Z, Jiao J, Zhang X, Wang X, Ying T, Wang H, Xie Y, Lu Y, Xu J, Lan F.
Journal Cell Rep
Impact factor7.7
Citation count26
Date of publishing2020 Jul 21