In vitro studies


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Key Findings
Anti-viral activity of six drugs (arbidol, baloxavir, laninamivir, oseltamivir, peramivir, and zanamivir) against SARS-Co-V-2 was tested and among them only arbidol compound demonstrated to efficiently inhibit the virus infection in vitro.
PMID 32373347
Title The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro
Author(s) nameWang X, Cao R, Zhang H, Liu J, Xu M, Hu H, Li Y, Zhao L, Li W, Sun X, Yang X, Shi Z, Deng F, Hu Z, Zhong W, Wang M.
Journal Cell Discov
Impact factor4.65
Citation count52
Date of publishing2020
Invitro activity of three Abl tyrosine kinase inhibitors- nilotinib, imatinib and dasatinib against SARS-CoV-2 was analysed in Vero-E6 and Calu-3 cells.
PMID 33232578
Title The tyrosine kinase inhibitor nilotinib inhibits SARS-CoV-2 in vitro
Author(s) nameCagno V, Magliocco G, Tapparel C, Daali Y.
Journal Basic Clin Pharmacol Toxicol
Impact factor2.29
Citation count1
Date of publishing2020 Nov 24
Antiviral activity of Naringenin against SARS-CoV-2
PMID 33096221
Title Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
Author(s) nameClementi N, Scagnolari C, D'Amore A, Palombi F, Criscuolo E, Frasca F, Pierangeli A, Mancini N, Antonelli G, Clementi M, Carpaneto A, Filippini A.
Journal Pharmacol Res
Impact factor5.78
Citation count2
Date of publishing2020 Oct 20
Invitro studies of chlorpheniramine shows strong virucidal effect against SARS-CoV-2 infected Vero cell line.
PMID 32963923
Title In Vitro Virucidal Effect of Intranasally Delivered Chlorpheniramine Maleate Compound Against Severe Acute Respiratory Syndrome Coronavirus 2
Author(s) nameWestover JB, Ferrer G, Vazquez H, Bethencourt-Mirabal A, Go CC.
Journal Cureus
Impact factorCant find
Citation count3
Date of publishing2020 Sep 17
Efficacy of remdesivir in a rhesus macaque infected with SARS-CoV-2 shows reduced pulmonary infiltrates and virus titres..
PMID 32516797
Title Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Author(s) nameWilliamson BN, Feldmann F, Schwarz B, Meade-White K, Porter DP, Schulz J, van Doremalen N, Leighton I, Yinda CK, Pérez-Pérez L, Okumura A, Lovaglio J, Hanley PW, Saturday G, Bosio CM, Anzick S, Barbian K, Cihlar T, Martens C, Scott DP, Munster VJ, de Wit E.
Journal Nature
Impact factor24.36
Citation count103
Date of publishing2020 Sep
Digoxin showed increased IC50 (by >2 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Camostat mesylate showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Tetrandrine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Berbamine hydrochloride showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Gilteritinib showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Chloroquine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Amodiaquine dihydrochloride showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Mefloquine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Cepharanthine showed increased IC50 (by >4 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Nafamostat mesylate showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Remdesivir showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Hydroxyprogesterone caproate showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Digitoxin showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Cyclosporine showed decreased IC50 (by <1 fold change) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Ouabain showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Eltrombopag showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Loperamide hydrochloride showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Hexachlorophene showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Ivacaftor showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7
Oxyclozanide showed unchanged IC50 (fold change approximately 1) in Calu-3 cells compared to Vero cells.
PMID 32767684
Title Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells
Author(s) nameKo M, Jeon S, Ryu WS, Kim S.
Journal J Med Virol
Impact factor2.07
Citation count5
Date of publishing2020 Aug 7