Drug target identification

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Key Findings
Comparative In silico analyses of SARS-CoV-2 genomic features (codon, codon pair, dinucleotide usage, and RNA structure around the frameshift region) was performed to find out the best potential target gene for codon pair deoptimization. Genes N and S are suggested as best targets, because of high codon pair bias (CPB) compared to that of other viral genes.
PMID 32973171
Title Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
Author(s) nameKames J, Holcomb DD, Kimchi O, DiCuccio M, Hamasaki-Katagiri N, Wang T, Komar AA, Alexaki A, Kimchi-Sarfaty C.
Journal Sci Rep
Impact factor4.12
Citation count2
Date of publishing2020 Sep 24