Rapid Antigen Test


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Key Findings
Compared to the SARS-CoV-2 RT-PCR assay, the SARS-CoV-2 Rapid Antigen Test (Roche, Switzerland) showed less sensitivity and specificity.
PMID 33227341
Title Comparision of the SARS-CoV-2 rapid antigen test to real star SARS-CoV-2 RT-PCR kit
Author(s) nameKrüttgen A, Cornelissen CG, Dreher M, Hornef MW, Imöhl M, Kleines M.
Journal J Virol Methods
Impact factor1.76
Citation count4
Date of publishing2021 Feb
In this study, the Rapid Antigen detection kit, STANDARD F COVID-19 Ag FIA (FIA), a fluorescent immunoassay, was evaluated for the rapid detection of SARS-CoV-2 nucleoprotein in PCR-positive and PCR-negative swab samples. The kit produced false-negative results, with overall clinical sensitivity and specificity of 45.4% and 97.8%, respectively.
PMID 33452927
Title Evaluation of two rapid antigen tests to detect SARS-CoV-2 in a hospital setting
Author(s) nameOsterman A, Baldauf HM, Eletreby M, Wettengel JM, Afridi SQ, Fuchs T, Holzmann E, Maier A, Döring J, Grzimek-Koschewa N, Muenchhoff M, Protzer U, Kaderali L, Keppler OT.
Journal Med Microbiol Immunol
Impact factor
Citation count1
Date of publishing2021 Jan 16
In this study, the Rapid Antigen detection kit, Roche SARS-CoV-2 Rapid Antigen Test (RAT), a chromatographic immunoassay, was evaluated for the rapid detection of SARS-CoV-2 N protein in PCR-positive and PCR-negative swab samples. The kit produced false-negative results, with overall clinical sensitivity and specificity of 50.3% and 97.7%, respectively.
PMID 33452927
Title Evaluation of two rapid antigen tests to detect SARS-CoV-2 in a hospital setting
Author(s) nameOsterman A, Baldauf HM, Eletreby M, Wettengel JM, Afridi SQ, Fuchs T, Holzmann E, Maier A, Döring J, Grzimek-Koschewa N, Muenchhoff M, Protzer U, Kaderali L, Keppler OT.
Journal Med Microbiol Immunol
Impact factor
Citation count1
Date of publishing2021 Jan 16
In this study, a nucleocapsid protein antigen test, based on fluorescence immunochromatographic (FIC) assay, was evaluated for the rapid detection of SARS-CoV-2 N protein antigen. With RT-PCR assay as the reference standard, this assay detected SARS-CoV-2 infection in 10 minutes, with the sensitivity, specificity, and percentage agreement of 75.6%, 100%, and 80.5%, respectively.
PMID 33031947
Title Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection
Author(s) nameDiao B, Wen K, Zhang J, Chen J, Han C, Chen Y, Wang S, Deng G, Zhou H, Wu Y.
Journal Clin Microbiol Infect
Impact factor6.17
Citation count9
Date of publishing2020 Oct 5
In this study, the Rapid Antigen detection kit, the BIOCREDIT COVID-19 Ag, was evaluated for diagnosing the SARS-CoV-2 virus in respiratory samples and compared with RT-PCR assay. This method was found less sensitive than RT-PCR. The kit produced false-negative results, and hence this test cannot individually diagnose a COVID-19 positive patient.
PMID 32585619
Title Evaluation of rapid antigen test for detection of SARS-CoV-2 virus
Author(s) nameMak GC, Cheng PK, Lau SS, Wong KK, Lau CS, Lam ET, Chan RC, Tsang DN.
Journal J Clin Virol
Impact factor2.95
Citation count29
Date of publishing2020 Aug