Biosensor based

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This study reports a rapid and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0) which provides a result within 4 minutes. The RAPID technology is based on electrochemical impedance spectroscopy (EIS), which transforms the binding event between the SARS-CoV-2 spike protein and receptor protein ACE2 into a detected electrical signal. The signal can be read through a desktop instrument or a smartphone. RAPID 1.0 is a good alternative to sophisticated diagnostic technique like RT-PCR. RAPID is inexpensive compared to existing methods for SARS-CoV-2 detection
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 		33997767
(Matter)
PMID
33997767
Date of Publishing: 2021 Jul 7
Title Low-cost Biosensor for Rapid Detection of SARS-CoV-2 at the Point-of-Care
Author(s) nameTorres MDT, de Araujo WR et al.
Journal Matter
Impact factor
- n/a -
Citation count: 16

Immunosensor based quantification of the ultralow concentration of cytokines (IL-6, TNF-alpha, etc.) present in blood or respiratory samples to monitor local and systemic inflammation. Limitation : Biosensors may have a drawback when detecting IL-6 in real matrices as proteins and mucin concentrations may interfere.
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 		33519090
(Sens Actuators B Chem)
PMID
33519090
Date of Publishing: 2021 Mar 1
Title Paper biosensors for detecting elevated IL-6 levels in blood and respiratory samples from COVID-19 patients
Author(s) nameAdrover-Jaume C, Alba-Patiño A et al.
Journal Sens Actuators B Chem
Impact factor
14.9
Citation count: 12

This study reports a low-cost, quantitative paper-based electrochemical sensor chip for the digital detection of SARS-CoV-2 within 5 minutes. The biosensor consists of the ssDNA-conjugated AuNPs (gold nanoparticles) that simultaneously target two separate regions of the same SARS-CoV-2 N-gene. The study showed a sensitivity of 231 (copies µL-1)-1 and a limit of detection of 6.9 copies/µL. The sensor chip had several advantages over previously reported tests, an improved limit of detection, no need for additional redox medium for electron exchange, faster response to achieve stable data, excellent shelf life, and its plausible economic production.
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 		33079516
(ACS Nano)
PMID
33079516
Date of Publishing: 2020 Oct 20
Title Rapid, Ultrasensitive, and quantitative detection of SARS-CoV-2 Using Antisense Oligonucletides Directed Electrochemical Biosensor Chip
Author(s) nameAlafeef M, Dighe K et al.
Journal ACS Nano
Impact factor
13.7
Citation count: 76

In this study, a simple electrochemical sensor-based diagnostic method is developed to detect the intensity of ROS levels in the sputum samples of candidates for early-stage screening of COVID-19. The assay resulted in accuracy and sensitivity of both 97% within 30 sec. The method provides an alternative to clinical judgment (HR-CT, ESR, CRP, CBC, Lymphopenia, and observational symptoms) and RT-PCR assays for fast screening of the patients who need a further medical examination.
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 		32729548
(Biosens Bioelectron)
PMID
32729548
Date of Publishing: 2020 Oct 1
Title Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.
Author(s) nameMiripour ZS, Sarrami-Forooshani R et al.
Journal Biosens Bioelectron
Impact factor
9.52
Citation count: 42