Animal studies

Last updated: 2021 Aug 23
Total hit(s): 5
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Cathepsin L (CTSL) levels increased in SARS-CoV-2 infected mice's liver.Cathepsin L inhibitor, Amantadine reduced the levels of CTSL. CTSL levels increased in the lungs of infected mice, on inhibitor treatment, no statistically significant result was observed.
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 		33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
- n/a -
Citation count: 73
Date of Entry 2021 Aug 23

Cathepsin L (CTSL) levels increased in SARS-CoV-2 infected mice's liver.Cathepsin L inhibitor, E64d reduced the levels of CTSL. CTSL levels increased in the lungs of mice infected with the pseudovirus, on inhibitor treatment no statistically significant result was observed.
✍
 		33774649
(Signal Transduct Target Ther)
PMID
33774649
Date of Publishing: 2021 Mar 27
Title Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development
Author(s) nameZhao MM, Yang WL et al.
Journal Signal Transduct Target Ther
Impact factor
- n/a -
Citation count: 73
Date of Entry 2021 Aug 23

Efficacy of remdesivir in a rhesus macaque infected with SARS-CoV-2 shows reduced pulmonary infiltrates and virus titres.. This study shows that remdesivir treatment should be considered as early as clinically possible to prevent progression to pneumonia in COVID-19 patients.
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 		32516797
(Nature)
PMID
32516797
Date of Publishing: 2020 Sep
Title Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Author(s) nameWilliamson BN, Feldmann F et al.
Journal Nature
Impact factor
24.36
Citation count: 325

Compound 13a has IC50 of 2.39 ± 0.63 µ;M against SARS-CoV-2 main protease. 13a was cleared at a rapid rate from plasma, at 24 hours it was found at 135 ng/g tissue in the lung and at 52.7 ng/ml in bronchio-alveolar lavage fluid (BALF), showing it was distributed into the tissues, thus very useful anti-coronavirus drug.
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 		32198291
(Science)
PMID
32198291
Date of Publishing: 2020 Apr 24
Title Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved -ketoamide inhibitors
Author(s) nameZhang L, Lin D et al.
Journal Science
Impact factor
20.57
Citation count: 1159

Compound 13b inhibits the purified recombinant SARS-CoV-2 Mpro with IC50 = 0.67 ± 0.18 μ;M. In human Calu-3 cells infected with SARS-CoV-2 it has an EC50 of 4 to 5 μ;M. After 24 hours, 13b was found at 33 ng/g in lung tissue. Inhalation was tolerated well and mice did not show any adverse effects, which suggests that direct administration of the compound to the lungs would be possible.
✍
 		32198291
(Science)
PMID
32198291
Date of Publishing: 2020 Apr 24
Title Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved -ketoamide inhibitors
Author(s) nameZhang L, Lin D et al.
Journal Science
Impact factor
20.57
Citation count: 1159