Auto Summaries

Last updated: 2024 Apr 18

Total hit(s): 2592

S.No.
1	38613382	Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.	N/A	Protein Cell	2024 Apr 13	5.52	1
2	38565636	Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.	N/A	Nature	2024 Apr	24.36	1
3	38272241		N/A		2024 Apr		1
4	38426653	Corrigendum: Corrigendum: Binding of Glycans to the SARS CoV-2 Spike Protein, an Open Question: NMR Data on Binding Site Localization, Affinity, and Selectivity.	N/A	Chemistry	2024 Mar 12		1
5	38062689	[Expert consensus on diagnosis and treatment of severe COVID-19 associated with pulmonary aspergillus and mucormycosis].	N/A	Zhonghua Jie He He Hu Xi Za Zhi	2023 Dec 8	0.137 (5 year)	1
6	38052838	Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia caused by the low-virulence virus SARS-CoV-2 Omicron variant.	N/A	Cell Discov	2023 Dec 5	4.65	1
7	36846890	Structure-based design of oligomeric receptor-binding domain (RBD) recombinant proteins as potent vaccine candidates against SARS-CoV-2.	The receptor-binding domain (RBD) of SARS-CoV-2 S protein is proved to be the major target of neutralizing antibodies. Only a portion of epitopes in RBD can be effectively displayed with dynamic changes in spatial conformations. Multimeric display of RBD molecules is a feasible strategy to optimize RBD-based vaccines.	Hum Vaccin Immunother	2023 Dec 31	4.7	1
8	37114433	Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism.	A triple deletion (DeltaSGF or DeltaLSG) in nonstructural protein 6 augments nsp6-mediated antagonism of type-I interferon (IFN-I) signaling. The impact of mutations outside the Spike gene are poorly understood, but they may alter pathogenesis of SARS-CoV-2 variants in humans. Analyses of host responses from DeltaSGF-WA1-infected mice and primary airway cultures reveal activation of pathways indicative of a cytokine storm.	Emerg Microbes Infect	2023 Dec	5.84	1
9	37394992	Rational design of an influenza-COVID-19 chimeric protective vaccine with HA-stalk and S-RBD.	A two-in-one vaccine would be ideal to avoid multiple vaccinations for these diseases. The S-RBD from SARS-CoV-2 Delta was fused to the headless HA from H1N1 (H1Delta), creating a chimera that forms trimers in solution. Immunization with the vaccine elicited high and long-lasting neutralizing antibodies.	Emerg Microbes Infect	2023 Dec	5.84	1
10	37919275	Cryo-EM structures of SARS-CoV-2 BA.2-derived subvariants spike in complex with ACE2 receptor.	N/A	Cell Discov	2023 Nov 2	4.65	1
11	37813850	Author Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses.	N/A	Cell Discov	2023 Oct 9	4.65	1
12	37342763	Two-Dimensional (2D) materials in the detection of SARS-CoV-2.	The SARS-CoV-2 pandemic has resulted in a devastating effect on human health in the last three years. Various detection methods like PCR-based methods, isothermal nucleic acid amplification-based (INAA) methods, serological methods or antibody tests have been exploited to diagnose SARS. Since 2D materials including graphene and graphene-related materials, transition metal carbides, carbonitrides, and nitrides (MXenes), and transition metal dichalcogenides (TMDs) play key roles in the development of novel and high-performance electrochemical (bio)sensors.	Microchem J	2023 Oct	6.5	1
13	37423659	Rapid diagnosis of COVID-19 using disposal paper capacitive sensor.	Since the start of COVID-19 pandemic in December 2019, many indisposal diagnostic tools are being developed incessantly. Out of all presently used tools, the gold standard rRT- PCR tool having very high sensitivity and specificity is a time consuming complicated molecular technique having requirements of special expensive equipment. The main focus of this work is to develop rapid disposal paper capacitance sensor having simple and easy detection.	Anal Chim Acta	2023 Sep 8	5.31	1
14	37257212	Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M(pro)).	Main protease (M(pro) has been validated as an effective anti-COVID-19 drug target. Compound C7 exhibits superior inhibitory activity against SARS-CoV-2 relative to baicalein. An X-ray co-crystal structure reveals a non-covalent mechanism of action.	Eur J Med Chem	2023 Sep 5	11.1	1
15	37244245	A polyethylene glycol enhanced ligation-triggered self-priming isothermal amplification for the detection of SARS-CoV-2 D614G mutation.	PEG enhanced ligation-triggered self-priming isothermal amplification (PEG-LSPA) for the detection D614G mutation in S-glycoprotein of SARS-CoV-2. The resulting DNA products can be monitored in real-time fluorescence signaling.	Talanta	2023 Sep 1	10.5	1
16	37332393	The anti-SARS-CoV-2 activity of novel 9, 10-dihydrophenanthrene derivatives: an insight into molecular docking, ADMET analysis, and molecular dynamics simulation.	Researchers used a 2D QSAR technique, ADMET analysis, molecular docking, and dynamic simulations to sort and evaluate the performance of thirty-nine bioactive analogues of 9,10-dihydrophenanthrene. The primary goal of the study is to use computational approaches to create a greater variety of structural references for the creation of more potent SARS-CoV-2 3Clpro inhibitors.	Sci Afr	2023 Sep	- n/a -	1
17	37228247	Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics.	" Both diabetes and Corona Virus Disease 2019 (COVID-19) are seriously harmful to human health, and they are closely related. It is of great significance to find drugs that can simultaneously treat diabetes and COVID-20. Based on theory of traditional Chinese medicine for treating COVI-19, this study sorted out compounds of Guizhou Miao medicine with ""return to the lung channel"" and ""clear heat and detoxify"" effects in China."	Arab J Chem	2023 Sep		1
18	37323221	A suitable drug structure for interaction with SARS-CoV-2 main protease between boceprevir, masitinib and rupintrivir; a molecular dynamics study.	The main protease of SARS-CoV-2 is an attractive target for the study of antiviral drugs against coronavirus diseases. According to the docking results, binding energy for boceprevir, masitinib and rupintrivir with CMP are -10.80, -9.39, and 9.51 kcal/mol respectively.	Arab J Chem	2023 Sep		1
19	37234226	Identification of potential Indonesian marine invertebrate bioactive compounds as TMPRSS2 and SARS-CoV-2 Omicron spike protein inhibitors through computational screening.	The SARS-CoV-2 Omicron variant, which swiftly spread worldwide, has fueled existing challenges. Acanthomanzamine C has remarkable effectiveness against TMPRSS2 and spike protein. Compared to camostat (-8.25 kcal/mol) nafamostat (co-crystal) and mefloquine (-6.34 km/mol), acanthoman zamine C binds to TMPR SS2 with binding energies of -9.75km/mol and 9.19cm/mol.	Arab J Chem	2023 Sep		1
20	37619583	The insights from SARS-CoV-2 antibody treatment for future emerging infectious diseases.	N/A	Lancet Infect Dis	2023 Aug 21	21.77	1
21	37428848	The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2.	A murine monoclonal antibody (mAb) designated E77 is reported which engages the prototype RBD with high affinity and potently neutralizes SARS-CoV-2 pseudoviruses. The capability of E77 to bind RBDs vanishes upon encountering variants of concern (VOCs) which carry the N501Y mutation, such as Alpha, Beta, Gamma and Omicron.	Acta Crystallogr D Struct Biol	2023 Aug 1		1
22	37193561	Compounds from myrtle flowers as antibacterial agents and SARS-CoV-2 inhibitors: In-vitro and molecular docking studies.	The chemical profile of hydrodistilled EO from myrtle flowers was determined using GC/MS analysis. 54 compounds were identified including the main components: alpha-pinene (48.94%) and 1,8-cineole (28.3%) whereas other minor compounds were detected. Escherichia coli (25 mm), Klebsiella oxytoca (20 mm) and Serratia marcescens are the most susceptible strains to the EO which is endowed with a bactericidal effect.	Arab J Chem	2023 Aug		1
23	36959870	Using low-cost disposable immunosensor based on flexible PET screen-printed electrode modified with carbon black and gold nanoparticles for sensitive detection of SARS-CoV-2.	The sensor developed is composed of a screen-printed electrode (SPE) array which was constructed using conductive carbon ink printed on polyethylene terephthalate (PET) substrate made from disposable soft drink bottles. The recognition site (Spike S1 Antibody (anti-SP Ab) was covalently immobilized on the working electrode surface, which was effectively modified with carbon black (CB) and gold nanoparticles (AuNPs)	Talanta Open	2023 Aug		1
24	37351185	Synthesis, characterization and identification of inhibitory activity on the main protease of COVID-19 by molecular docking strategy of (4-oxo-piperidinium ethylene acetal) trioxonitrate.	Single crystal X-ray diffraction suggests, (4-OPEAN) with the chemical formula (C(7)H(12)NO(2) belongs to the orthorhombic space group Pnma. The material may exhibit inhibiting effects on the 6Y84 and 7EJY virus proteins from corona (COVID-19)	J King Saud Univ Sci	2023 Aug	2.94	1
25	37169138		N/A		2023 Aug		1